CAS 163252-36-6

clevudina

Descripción:

clevudina es un análogo de nucleósido antiviral que se investiga principalmente por su potencial en el tratamiento de infecciones crónicas por el virus de la hepatitis B (VHB). Se caracteriza por su similitud estructural con los nucleósidos que ocurren de forma natural, lo que le permite interferir con la replicación viral. clevudina funciona inhibiendo la enzima polimerasa viral, evitando así la síntesis de ADN viral. Este compuesto se administra típicamente por vía oral y ha mostrado promesas en ensayos clínicos por su eficacia y perfil de seguridad. Su mecanismo de acción implica la incorporación selectiva en el ADN viral, lo que lleva a la terminación de la cadena durante la replicación. clevudina es notable por sus propiedades farmacocinéticas relativamente favorables, que incluyen buena biodisponibilidad y una vida media manejable. Sin embargo, al igual que muchos agentes antivirales, puede estar asociado con efectos secundarios, y la resistencia puede desarrollarse con el uso prolongado. La investigación en curso continúa evaluando su efectividad a largo plazo y su posible papel en terapias combinadas para el VHB. En general, clevudina representa un avance significativo en el arsenal farmacológico contra la hepatitis B.

Fórmula: C₁₀H₁₃FN₂O₅

InChI: InChI=1/C10H13FN2O5/c1-4-2-13(10(17)12-8(4)16)9-6(11)7(15)5(3-14)18-9/h2,5-7,9,14-15H,3H2,1H3,(H,12,16,17)/t5-,6+,7-,9-/m0/s1

Clave InChI: InChIKey=GBBJCSTXCAQSSJ-XQXXSGGOSA-N

SMILES: F[C@H]1[C@H](O[C@@H](CO)[C@@H]1O)N2C(=O)NC(=O)C(C)=C2

Sinónimos:

• 1-(2-Deoxy-2-fluoro-b-L-arabinofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione
• 1-(2-Deoxy-2-fluoro-beta-L-arabinofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione
• 1-(2-Deoxy-2-fluoro-β-<span class="text-smallcaps">L</span>-arabinofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione
• 1-(2′-Deoxy-2′-fluoro-β-<span class="text-smallcaps">L</span>-arabinofuranosyl)-5-methyluracil
• 2'-Fluoro-5-methyl-b-L-arabinofuranosyluracil
• 2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-2-fluoro-β-<span class="text-smallcaps">L</span>-arabinofuranosyl)-5-methyl-
• 2,4(1H,3H)-pyrimidinedione, 1-(2-deoxy-2-fluoro-beta-L-arabinofuranosyl)-5-methyl-
• L-Fmau
• Levovir
• Clevudine
• 2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-2-fluoro-β-L-arabinofuranosyl)-5-methyl-
• 1-(2′-Deoxy-2′-fluoro-β-L-arabinofuranosyl)-5-methyluracil
• Clevudine(Levovir)
• CLEVUDINE: 1-(2''-DEOXY-2''-FLUORO-BETA-L-ARABINOFURANOSYL)-5-METHYLURACIL
• 1-((2S,3R,4S,5S)-3-Fluoro-4-hydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)-5-MethylpyriMidine-2,4(1H,3H)-dione
• 1-((2S,3R,4S,5S)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4
• 1-[(2S,3R,4S,5S)-3-fluoro-4-hydroxy-5-methylol-tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-quinone
• 1-((2S,3R,4S,5S)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-
• 1-(2''-DEOXY-2''-FLUORO--L-ARABINOFURANOSYL)-5-METHYLURACIL
• 1-[(2S,3R,4S,5S)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
• 1-[(2S,3R,4S,5S)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methyl-pyrimidine-2,4-dione
• CLEVUDINE: 1-(2''-DEOXY-2''-FLUORO-SS-L-ARABINOFURANOSYL)-5-METHYLURACIL
• CLEVUDINE, 1-(2'-DEOXY-2'-FLUORO-β-L-ARABINOFURANOSYL)-5-METHYLURACIL
• Clevudine USP/EP/BP
• 2'-Fluoro-5-methylarabinosyluracil
• 2'-F-2'-ara-dT

2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-2-fluoro-β-L-arabinofuranosyl)-5-methyl-

CAS: 163252-36-6

Fórmula: C₁₀H₁₃FN₂O₅

Pureza: 97%

Forma y color: Solid

Peso molecular: 260.2190

Ref: IN-DA001TY5

Clevudine

CAS: 163252-36-6

Clevudine

Fórmula: C₁₀H₁₃FN₂O₅

Pureza: ≥98%

Peso molecular: 260.22

Ref: 54-BUP06493

Clevudine

CAS: 163252-36-6

Clevudine

Fórmula: C₁₀H₁₃FN₂O₅

Pureza: 98%

Peso molecular: 260.22

Ref: 54-PC108998

Clevudine

CAS: 163252-36-6

Clevudine (Levovir) fights HBV, blocks viral DNA synthesis, and has a long half-life reducing relapse risk after treatment.

Fórmula: C₁₀H₁₃FN₂O₅

Pureza: 99.88% - 99.97%

Forma y color: White Solid

Peso molecular: 260.22

Ref: TM-T6446

Clevudine

CAS: 163252-36-6

Fórmula: C₁₀H₁₃FN₂O₅

Pureza: ≥ 98.0%

Forma y color: White to off-white powder

Peso molecular: 260.22

Ref: 7W-GP8280

Clevudine

CAS: 163252-36-6

Clevudine is a synthetic pyrimidine analogue effective against the hepatitis B virus (HBV). Once inside the cell, it is converted into its active forms, clevudine monophosphate and clevudine triphosphate. The triphosphate form competes with thymidine to be incorporated into viral DNA, leading to DNA chain termination and inhibition of the HBV DNA polymerase (reverse transcriptase). Due to its long half-life, clevudine significantly reduces covalently closed circular DNA (cccDNA), making relapse less likely after treatment ends.

Fórmula: C₁₀H₁₃FN₂O₅

Pureza: Min. 95%

Forma y color: White Powder

Peso molecular: 260.22 g/mol

Ref: 3D-NC09470

Clevudine

CAS: 163252-36-6

1-((2S,3R,4S,5S)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

Fórmula: C₁₀H₁₃FN₂O₅

Pureza: 98%

Peso molecular: 260.22

Ref: IN-DG50031

1-((2S,3R,4S,5S)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

CAS: 163252-36-6

Fórmula: C₁₀H₁₃FN₂O₅

Pureza: 97%

Forma y color: Solid

Peso molecular: 260.221

Ref: 10-F235704

Clevudine

Producto controlado

CAS: 163252-36-6

Applications Antiviral drug, used for the treatment of Hepatitis B.
References Kwon, S., et al.: J. Virol., 84, 4494 (2010), Daga, P., et al.: Protein Sci., 19, 796 (2010),

Fórmula: C₁₀H₁₃FN₂O₅

Forma y color: Neat

Peso molecular: 260.22

Ref: TR-C574150

Clevudine

CAS: 163252-36-6

Fórmula: C₁₀H₁₃FN₂O₅

Peso molecular: 260.22

Ref: ST-EA-CP-C357000