CAS 163680-77-1
:Metanosulfonato de pazufloxacina
Descripción:
El metanosulfonato de pazufloxacina es un antibiótico fluoroquinolona sintético caracterizado por su actividad antibacteriana de amplio espectro. Se utiliza principalmente en el tratamiento de diversas infecciones bacterianas, particularmente aquellas causadas por organismos Gram-negativos y algunos Gram-positivos. El compuesto exhibe un mecanismo de acción que implica la inhibición de la girasa del ADN bacteriano y la topoisomerasa IV, enzimas críticas para la replicación y transcripción del ADN. La pazufloxacina es conocida por sus favorables propiedades farmacocinéticas, que incluyen una buena biodisponibilidad oral y penetración en los tejidos, lo que mejora su eficacia terapéutica. La forma de sal de metanosulfonato mejora su solubilidad y estabilidad, haciéndola adecuada para la formulación en diversas formas de dosificación. Además, se ha estudiado la pazufloxacina por su posible uso en el tratamiento de infecciones del tracto respiratorio y del tracto urinario. Al igual que otros fluoroquinolonas, puede estar asociada con efectos secundarios, incluidos trastornos gastrointestinales y posibles efectos en la salud de los tendones. En general, el metanosulfonato de pazufloxacina representa una opción valiosa en el arsenal de antibióticos, particularmente en el contexto del aumento de la resistencia a los antibióticos.
Fórmula:C17H19FN2O7S
InChI:InChI=1/C16H15FN2O4.CH4O3S/c1-7-6-23-14-11(16(18)2-3-16)10(17)4-8-12(14)19(7)5-9(13(8)20)15(21)22;1-5(2,3)4/h4-5,7H,2-3,6,18H2,1H3,(H,21,22);1H3,(H,2,3,4)/t7-;/m0./s1
Clave InChI:InChIKey=UDHGFPATQWQARM-FJXQXJEOSA-N
SMILES:O=C1C=2C3=C(C(=C(F)C2)C4(N)CC4)OC[C@H](C)N3C=C1C(O)=O.S(C)(=O)(=O)O
Sinónimos:- (3S)-10-(1-Aminocyclopropyl)-9-Fluoro-2,3-Dihydro-3-Methyl-7-Oxo-7H-Pyrido[1,2,3-De]-1,4-Benzoxazine-6-Carboxylic Acid Methanesulfonate
- (3S)-10-(1-aminocyclopropyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid methanesulfonate
- (S)-(-)-10-(1-aminocyclopropyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine -6-carboxylic acid monomethanesulfonate
- 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, (3S)-, methanesulfonate (1:1)
- 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, (3S)-, monomethanesulfonate
- 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, (S)-, monomethanesulfonate
- 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, monomethanesulfonate (9CI)
- Pasil
- Pazucross
- Pazufloxacin Mesilate
- Pazufloxacin Mesylate
- Pazufloxacin Methanesulfonate
- T 3762
- (3S)-10-(1-Aminocyclopropyl)-9-fluror-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylicAcid,
- Pazufloxacin mesilate VETRANAL
- pazufloxaxin methanesulfonate
- Pazufloxacin Monomethanesulfonate
- 2,3-de)-1,4-benzoxazine-6-carboxylicacid,2,3-dihydro-10-(1-aminocyclopropyl)-9-fluoro-3-methyl-7-oxo-7h-pyrido((s)-7h-pyrido(monomethanesulfonate
- (s)-yclopropyl)-9-fluoro-3-methyl-7-oxomonomethanesulfonate
- (3S)-10-(1-Aminocyclopropyl)-9-fluror-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid, T-3761,
- 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, (3S)-, monomethanesulfonate (9CI)
- Pazufloxacin mesylate, Pazufloxacin methanesulfonate
- PAZUFLOXAXIN METHANESULFONATE 99%
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Se han encontrado 14 productos.
Pazufloxacin Mesylate
CAS:Pazufloxacin MesylateFórmula:C16H15FN2O4·CH4O3SPureza:≥98%Peso molecular:414.4Pazufloxacin Mesylate
CAS:Pazufloxacin MesylateFórmula:C16H15FN2O4CH4O3SPureza:98%Peso molecular:414.4Pazufloxacin Mesylate
CAS:Pazufloxacin Mesylate (T-3762) is a fluoroquinolone antibiotic.Fórmula:C16H15FN2O4·CH4O3SPureza:99.88% - 99.93%Forma y color:SolidPeso molecular:414.4(2S)-6-(1-aminocyclopropyl)-7-fluoro-2-methyl-10-oxo-4-oxa-1-azatricyclo[7.3.1.0^{5,13}]trideca-5,7,9(13),11-tetraene-11-carboxylic acid; methanesulfonic acid
CAS:Fórmula:C17H19FN2O7SPureza:98%Forma y color:SolidPeso molecular:414.4054Pazufloxacin Mesylate
CAS:Fórmula:C16H15FN2O4·CH4O3SForma y color:White To Off-White SolidPeso molecular:318.31 96.11Pazufloxacin Mesylate
CAS:(S)-10-(1-Aminocyclopropyl)-9-fluoro-3-methyl-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid methanesulfonic acid saltFórmula:C17H19FN2O7SPureza:98%Peso molecular:414.41Pazufloxacin mesylate
CAS:Pazufloxacin mesylate is an antimicrobial agent that inhibits bacterial growth by binding to bacterial DNA gyrase and topoisomerase IV. Pazufloxacin mesylate has been shown to have a synergistic effect with other antibiotics. It has been shown to be effective against a number of human pathogens, including Staphylococcus aureus, Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria gonorrhoeae. Pazufloxacin mesylate is not active against acid-fast bacteria such as Mycobacterium tuberculosis or Mycobacterium avium complex. The inhibition of cell division by pazufloxacin mesilate may be due to the inhibition of rna synthesis and protein synthesis. This antibiotic also causes a decrease in locomotor activity in mice, which may be due to its ability to inhibit the release of inflammatory mediators
Fórmula:C17H19FN2O7SPureza:Min. 95%Forma y color:White PowderPeso molecular:414.41 g/molPazufloxacin Mesylate
CAS:Fórmula:C16H15FN2O4·CH4O3SPureza:>98.0%(T)(HPLC)Forma y color:White to Orange to Green powder to crystalPeso molecular:414.40Pazufloxacin Mesylate
CAS:Producto controladoApplications A fluorinated quinolone antibiotic. Antibacterial.
References Fukuoka,Y., et al.: Antimicrob. Ag. Chemother., 37, 384 (1993), Todo, Y., et al.: Chem. Pharm. Bull., 42, 2569 (1994)Fórmula:C16H15FN2O4·CH4O3SForma y color:NeatPeso molecular:414.41
![(2S)-6-(1-aminocyclopropyl)-7-fluoro-2-methyl-10-oxo-4-oxa-1-azatricyclo[7.3.1.0^{5,13}]trideca-5,…](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FIN%2Fthumb%2FDA001UB2.jpg&w=3840&q=75)
