CAS 1660114-31-7

Fórmula: C20H19N3O4

InChI: InChI=1S/C20H19N3O4/c1-23-9-8-20(26,19(23)25)7-6-13-4-3-5-14(10-13)16-11-15(27-2)12-17(22-16)18(21)24/h3-5,10-12,26H,8-9H2,1-2H3,(H2,21,24)/t20-/m0/s1

Clave InChI: LQSHXYHWYGKAMX-FQEVSTJZSA-N

SMILES: CN1CC[C@](C1=O)(C#CC2=CC(=CC=C2)C3=NC(=CC(=C3)OC)C(=O)N)O

NIK SMI1

CAS: 1660114-31-7

NIK SMI1 is an effective and selective NF-κB inducing kinase (NIK) inhibitor. It also inhibits NIK-catalyzed hydrolysis of ATP to ADP (IC50: 0.23±0.17 nM).

Fórmula: C₂₀H₁₉N₃O₄

Pureza: 99.04% - 99.99%

Forma y color: Solid

Peso molecular: 365.3826

Ref: TM-T16290

NIK SMI1

CAS: 1660114-31-7

Fórmula: C₂₀H₁₉N₃O₄

Pureza: 99%

Forma y color: Solid

Peso molecular: 365.3826

Ref: IN-DA01FNPQ

NIK SMI1

CAS: 1660114-31-7

NIK SMI1

Fórmula: C₂₀H₁₉N₃O₄

Pureza: ≥98%

Forma y color: Solid

Peso molecular: 365.38

Ref: 54-BUP05383

NIK SMI1

CAS: 1660114-31-7

(R)-6-(3-((3-Hydroxy-1-methyl-2-oxopyrrolidin-3-yl)ethynyl)phenyl)-4-methoxypicolinamide

Fórmula: C₂₀H₁₉N₃O₄

Pureza: 99%

Peso molecular: 365.38

Ref: IN-DG01113063

NIK SMI1

CAS: 1660114-31-7

A knockout mouse model of the SMI1 gene was used to study the effects of this gene on cancer onset and progression. The SMI1 protein is found in the cytosol and nucleus, where it regulates apoptosis and cell cycle progression. Knockout mice with a mutation in the SMI1 gene demonstrated increased autolysis, tumour growth, and tumour volume. These results suggest that SMI1 may be an effective target for therapeutic intervention.

Fórmula: C₂₀H₁₉N₃O₄

Pureza: Min. 95%

Peso molecular: 365.4 g/mol

Ref: 3D-KRC11431