CAS 16941-32-5

glucagón

Descripción:

glucagón es una hormona peptídica producida por las células alfa del páncreas, involucrada principalmente en el metabolismo de la glucosa. Está compuesta por 29 aminoácidos y juega un papel crucial en el aumento de los niveles de glucosa en sangre al promover la glucogenólisis y la gluconeogénesis en el hígado. glucagón se libera típicamente en respuesta a niveles bajos de azúcar en sangre, actuando como una hormona contrarreguladora de la insulina. Su estructura incluye una cadena única de aminoácidos con grupos funcionales específicos que facilitan su actividad biológica. El número CAS 16941-32-5 identifica a glucagón en bases de datos químicas, asegurando una comunicación precisa sobre esta sustancia. En contextos terapéuticos, glucagón se utiliza como medicamento para tratar la hipoglucemia severa y se administra por inyección. También se utiliza en procedimientos diagnósticos, como en estudios de imagen del tracto gastrointestinal. En general, glucagón es esencial para mantener la homeostasis de la glucosa y es un jugador clave en la regulación metabólica.

Fórmula: C₁₅₃H₂₂₅N₄₃O₄₉S

InChI: InChI=1/C153H225N43O49S/c1-72(2)52-97(133(226)176-96(47-51-246-11)132(225)184-104(60-115(159)209)143(236)196-123(78(10)203)151(244)245)179-137(230)103(58-83-64-167-89-29-19-18-28-87(83)89)183-131(224)95(43-46-114(158)208)177-148(241)120(74(5)6)194-141(234)101(54-79-24-14-12-15-25-79)182-138(231)105(61-117(211)212)185-130(223)94(42-45-113(157)207)171-124(217)75(7)170-127(220)91(31-22-49-165-152(160)161)172-128(221)92(32-23-50-166-153(162)163)174-146(239)110(69-199)191-140(233)107(63-119(215)216)186-134(227)98(53-73(3)4)178-135(228)99(56-81-33-37-85(204)38-34-81)180-129(222)90(30-20-21-48-154)173-145(238)109(68-198)190-136(229)100(57-82-35-39-86(205)40-36-82)181-139(232)106(62-118(213)214)187-147(240)111(70-200)192-150(243)122(77(9)202)195-142(235)102(55-80-26-16-13-17-27-80)188-149(242)121(76(8)201)193-116(210)66-168-126(219)93(41-44-112(156)206)175-144(237)108(67-197)189-125(218)88(155)59-84-65-164-71-169-84/h12-19,24-29,33-40,64-65,71-78,88,90-111,120-123,167,197-205H,20-23,30-32,41-63,66-70,154-155H2,1-11H3,(H2,156,206)(H2,157,207)(H2,158,208)(H2,159,209)(H,164,169)(H,168,219)(H,170,220)(H,171,217)(H,172,221)(H,173,238)(H,174,239)(H,175,237)(H,176,226)(H,177,241)(H,178,228)(H,179,230)(H,180,222)(H,181,232)(H,182,231)(H,183,224)(H,184,225)(H,185,223)(H,186,227)(H,187,240)(H,188,242)(H,189,218)(H,190,229)(H,191,233)(H,192,243)(H,193,210)(H,194,234)(H,195,235)(H,196,236)(H,211,212)(H,213,214)(H,215,216)(H,244,245)(H4,160,161,165)(H4,162,163,166)/t75-,76+,77+,78+,88-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,120-,121-,122-,123-/m0/s1

Clave InChI: MASNOZXLGMXCHN-ZLPAWPGGSA-N

SMILES: C[C@H]([C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC3=CC=C(C=C3)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC4=CC=CC=C4)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC5=CNC6=CC=CC=C65)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H]([C@@H](C)O)C(=O)O)NC(=O)CNC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC7=CN=CN7)N)O

Sinónimos:

• Glucagon (1-29) (human, bovine, porcine)
• Glucagon, human recombinant
• H-His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-OH
• L-histidyl-L-seryl-L-glutaminylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-alpha-aspartyl-L-tyrosyl-L-seryl-L-lysyl-L-tyrosyl-L-leucyl-L-alpha-aspartyl-L-seryl-L-arginyl-L-arginyl-L-alanyl-L-glutaminyl-L-alpha-aspartyl-L-phenylalanyl-L-valyl-L-glutaminyl-L-tryptophyl-L-leucyl-L-methionyl-L-asparaginyl-L-threonine
• Glucagon Hydrochloride(Human)

Glucagon (1-29) (human, rat, porcine)

CAS: 16941-32-5

Bachem ID: 4088814.

Fórmula: C₁₅₃H₂₂₅N₄₃O₄₉S

Pureza: 96.4%

Forma y color: White Lyophilisate

Peso molecular: 3482.8

Ref: 01-4088814

HUMAN GLUCAGON CRS

CAS: 16941-32-5

HUMAN GLUCAGON CRS

Fórmula: C₁₅₃H₂₂₅N₄₃O₄₉S

Peso molecular: 3482.747

Ref: 41-Y0000191

Glucagon (HUMAN)

CAS: 16941-32-5

Polypeptide, protein and glycoprotein hormones, their derivatives and structural analogues, nesoi

Fórmula: C₁₅₃H₂₂₅N₄₃O₄₉S

Forma y color: White Powder

Peso molecular: 3480.6157

Ref: 45-1294036

Glucagon

CAS: 16941-32-5

Fórmula: C₁₅₃H₂₂₅N₄₃O₄₉S

Pureza: 99%

Forma y color: Solid

Peso molecular: 3482.7473

Ref: IN-DA0039VM

Glucagon PentaHCl

CAS: 16941-32-5

Fórmula: C₁₅₃H₂₂₅N₄₃O₄₉S·5HCl

Peso molecular: 3482.80 5*36.46

Ref: 4Z-PG-194012

Glucagon

CAS: 16941-32-5

Fórmula: C₁₅₃H₂₂₅N₄₃O₄₉S

Pureza: (HPLC) ≥ 95.0%

Forma y color: White powder

Peso molecular: 3482.75

Ref: 7W-GX2829

Glucagon

CAS: 16941-32-5

Fórmula: C₁₅₃H₂₂₅N₄₃O₄₉S

Peso molecular: 3482.80

Ref: 4Z-PG-194007

Glucagon (1-29), bovine, human, porcine

CAS: 16941-32-5

Corynoxine B (Cory B) is a naturally occurring alkaloid isolated from Uncaria rhynchophylla (Miq. ) and is an autophagy inducer.

Fórmula: C₁₅₃H₂₂₅N₄₃O₄₉S

Pureza: 99.56% - 99.91%

Forma y color: Solid

Peso molecular: 3482.75

Ref: TM-T15389

Glucagon Hydrochlide

CAS: 16941-32-5

Fórmula: C₁₅₃H₂₂₅N₄₃O₄₉S

Pureza: 95%~99%

Forma y color: White to Off-white Powder

Peso molecular: 3482.75

Ref: BP-BPPG036

Glucagon RS

CAS: 16941-32-5

Forma y color: White Solid

Ref: 2K-104840002

Glucagon (1-29), bovine, human, porcine

CAS: 16941-32-5

Fórmula: C₁₅₃H₂₂₅N₄₃O₄₉S

Peso molecular: 3482.7

Ref: BE-RMCP492007

Glucagon (Human)

CAS: 16941-32-5

Glucagon (Human) is a recombinant peptide hormone, which is synthesized to mimic the natural glucagon produced by alpha cells in the pancreas. This biopharmaceutical is derived from a DNA recombinant technology source, offering a high level of purity and consistency. Its mode of action involves binding to glucagon receptors on liver cells, stimulating glycogenolysis and gluconeogenesis. This results in the rapid conversion of glycogen into glucose, thereby raising blood sugar levels.Glucagon (Human) is primarily utilized in the treatment of severe hypoglycemia, especially in diabetic patients unable to consume oral glucose due to unconsciousness or confusion. Its application is critical in acute settings where rapid intervention is necessary to prevent neurological damage from prolonged hypoglycemia. Additionally, the research and clinical use of glucagon extend to investigating its potential in counteracting beta-blocker and calcium channel blocker overdoses, where it acts to increase cardiac output. This hormone's pharmaceutical development has provided a crucial tool in both emergency response and broader therapeutic research contexts.

Fórmula: C₁₅₃H₂₂₅N₄₃O₄₉S

Pureza: Min. 95%

Peso molecular: 3,482.7 g/mol

Ref: 3D-PGL-4098-S

Glucagon (1-29), bovine, human, porcine

CAS: 16941-32-5

Glucagon (1-29), bovine, human, porcine, is a peptide hormone, which is derived from bovine, human, and porcine sources. It comprises 29 amino acids and functions as a crucial regulator of glucose metabolism by promoting the increase of blood glucose levels. The mode of action involves binding to receptors on liver cells, activating adenylate cyclase, and subsequently increasing intracellular cyclic AMP. This cascade triggers glycogenolysis and gluconeogenesis, leading to elevated blood glucose.In scientific research, Glucagon (1-29), bovine, human, porcine, is utilized to study metabolic pathways and the regulation of glucose homeostasis. Its applications extend to diabetes research, where it serves as a model for understanding glucagon's role in insulin resistance and pancreatic beta-cell dysfunction. Furthermore, this product is employed in the development of therapeutic strategies for hypoglycemic events experienced by diabetic patients. It also serves as a tool in pharmacological studies to elucidate receptor-ligand interactions and signaling mechanisms in different species.

Fórmula: C₁₅₃H₂₂₅N₄₃O₄₉S

Pureza: Min. 95%

Peso molecular: 3,482.78 g/mol

Ref: 3D-PG16975

Glucagon

CAS: 16941-32-5

Fórmula: C₁₅₃H₂₂₅N₄₃O₄₉S

Peso molecular: 3482.8

Ref: ST-EA-CP-G38025

Glucagon (1-29) (human, rat, porcine)

CAS: 16941-32-5

Glucagon is a 29 amino acid containing peptide hormone processed from proglucagon. As a counterregulatory hormone for insulin, glucagon plays a critical role in maintaining glucose homeostasis in vivo in both animals and humans. Not surprisingly, glucagon and glucagon receptor have been pursued extensively as potential targets for the therapeutic treatment of diabetes. As Aβ peptides and IAPP, glucacon tends to form gel-like fibrillar aggregates. These fibrils were found to be toxic through the activation of apoptotic signaling pathways. Hence the aggregation behavior of glucagon has been studied extensively.

Fórmula: C₁₅₃H₂₂₅N₄₃O₄₉S

Pureza: 100.0%

Forma y color: White Powder

Peso molecular: 3482.8

Ref: 01-4033017

Glucagon RS

CAS: 16941-32-5

Forma y color: White Solid

Ref: 2K-1048400021