CAS 170729-80-3

Aprepitant

Descripción:

Aprepitant es un antagonista selectivo del receptor de neuroquinina-1 (NK1), utilizado principalmente en la prevención de náuseas y vómitos asociados con la quimioterapia y la cirugía. Se clasifica como una molécula pequeña y a menudo se administra por vía oral. Aprepitant exhibe una alta afinidad por el receptor NK1, que juega un papel crucial en la respuesta emética mediada por la sustancia P, un neuropéptido involucrado en la percepción del dolor y la inflamación. La sustancia se caracteriza por su relativamente baja solubilidad en agua, lo que influye en su formulación y biodisponibilidad. Aprepitant se utiliza típicamente en combinación con otros agentes antieméticos para mejorar la eficacia terapéutica. Su farmacocinética implica un extenso metabolismo en el hígado, principalmente a través del sistema del citocromo P450, lo que puede llevar a interacciones medicamentosas. Los efectos secundarios comunes pueden incluir fatiga, mareos y trastornos gastrointestinales. En general, Aprepitant representa un avance significativo en el manejo de las náuseas y vómitos inducidos por quimioterapia, mejorando la calidad de vida de los pacientes que se someten a tratamiento contra el cáncer.

Fórmula: C₂₃H₂₁F₇N₄O₃

InChI: InChI=1S/C23H21F7N4O3/c1-12(14-8-15(22(25,26)27)10-16(9-14)23(28,29)30)37-20-19(13-2-4-17(24)5-3-13)34(6-7-36-20)11-18-31-21(35)33-32-18/h2-5,8-10,12,19-20H,6-7,11H2,1H3,(H2,31,32,33,35)/t12-,19+,20-/m1/s1

Clave InChI: InChIKey=ATALOFNDEOCMKK-OITMNORJSA-N

SMILES: C(N1[C@H]([C@@H](O[C@H](C)C2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)OCC1)C3=CC=C(F)C=C3)C4=NNC(=O)N4

Sinónimos:

• 3H-1,2,4-Triazol-3-one, 5-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-
• 3H-1,2,4-Triazol-3-one, 5-[[2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-, [2R-[2α(R*),3α]]-
• 5-[2(R)-[1(R)-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3(S)-(4-fluorophenyl)morpholin-4-ylmethyl]-3,4-dihydro-2H-1,2,4-triazol-3-one
• 5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,
• 5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one
• 5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one, Emend
• 5-{[(2R,3S)-2-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}-3-(4-fluorophenyl)morpholin-4-yl]methyl}-1,2-dihydro-3H-1,2,4-triazol-3-one
• Emend
• L 754030
• Mk 869
• Mk-0869

Aprepitant

CAS: 170729-80-3

Fórmula: C₂₃H₂₁F₇N₄O₃

Pureza: >98.0%(HPLC)

Forma y color: White to Almost white powder to crystal

Peso molecular: 534.43

Ref: 3B-A3135

Aprepitant impurity standard

CAS: 170729-80-3

Aprepitant impurity standard

Forma y color: Off White Solid

Ref: 47-1148

Aprepitant

CAS: 170729-80-3

Aprepitant

Fórmula: C₂₃H₂₁F₇N₄O₃

Pureza: 99.9%

Forma y color: White. To. Beige

Peso molecular: 534.15019

Ref: 47-1138

APREPITANT CRS

CAS: 170729-80-3

APREPITANT CRS

Fórmula: C₂₃H₂₁F₇N₄O₃

Peso molecular: 534.4267

Ref: 41-Y0001825

Aprepitant

CAS: 170729-80-3

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Fórmula: C₂₃H₂₁F₇N₄O₃

Forma y color: White Off-White Powder

Peso molecular: 534.15019

Ref: 45-1041904

5-{[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl}-2,3-dihydro-1H-1,2,4-triazol-3-one

CAS: 170729-80-3

Fórmula: C₂₃H₂₁F₇N₄O₃

Pureza: 98%

Forma y color: Solid

Peso molecular: 534.4267

Ref: IN-DA0034H4

Aprepitant Impurity 31

CAS: 170729-80-3

Fórmula: C₂₇H₂₄F₇NO₂

Forma y color: White To Off-White Solid

Peso molecular: 527.49

Ref: 4Z-A-3212

Aprepitant

CAS: 170729-80-3

Aprepitant

Pureza: 99%

Peso molecular: 534.43g/mol

Ref: 54-PC109217

Aprepitant

CAS: 170729-80-3

Aprepitant

Pureza: ≥98%

Peso molecular: 534.43g/mol

Ref: 54-BUP15404

Aprepitant

CAS: 170729-80-3

Fórmula: C₂₃H₂₁F₇N₄O₃

Forma y color: White To Off-White Solid

Peso molecular: 534.43

Ref: 4Z-A-321

Aprepitant

CAS: 170729-80-3

Fórmula: C₂₃H₂₁F₇N₄O₃

Pureza: (HPLC) ≥ 98.0%

Forma y color: White to off-white powder

Peso molecular: 534.43

Ref: 7W-GP4641

Aprepitant

Producto controlado

CAS: 170729-80-3

Fórmula: C₂₃H₂₁F₇N₄O₃

Forma y color: Neat

Peso molecular: 534.43

Ref: 86-MM3251.00

Aprepitant

CAS: 170729-80-3

Aprepitant (Aprepitant`) is a Substance P/Neurokinin-1 Receptor Antagonist.

Fórmula: C₂₃H₂₁F₇N₄O₃

Pureza: 98% - 99.68%

Forma y color: Off-White To Light Yellow Cyrstalline Solid

Peso molecular: 534.43

Ref: TM-T1743

Aprepitant

CAS: 170729-80-3

Fórmula: C₂₃H₂₁F₇N₄O₃

Ref: TR-TRC-A729800

Aprepitant

Producto controlado

CAS: 170729-80-3

Applications Aprepitant is a neurokinin-1 antagonist and an antiemetic agent (1). It is used to prevent chemotherapy-induced nausea and vomiting (CINV) in colorectal cancer patients (2) Aprepitant has also been shown to induce apoptotic cell death and G1 arrest through Akt/p53 axis in pre-B acute lymphoblastic leukemia cells (3).
References (1) Takemoto, H., et al.: nt J Clin Oncol (2016) (2) Bayati, S., et al.: Eur J Pharmacol. 791, 274 (2016) (3) Navari, R.M.: Expert Rev Anticancer Ther. 4, 715 (2004)

Fórmula: C₂₃H₂₁F₇N₄O₃

Forma y color: Off-White

Peso molecular: 534.43

Ref: TR-A729800

Aprepitant - Bio-X ™

CAS: 170729-80-3

Aprepitant is a neurokinin-1 receptor antagonist. It is an antiemetic which suppresses nausea and vomiting and has proven to be especially useful alongside cancer chemotherapy and as a tool in cancer-related studies. Aprepitant binds to the neurokinin-1 receptor in the brain, preventing it from binding to substance P. This prevents substance P from stimulating nerves in the vomiting center of the brain, reducing feelings of nausea and vomiting. Aprepitant has been shown to be effective against HIV infection, with no major side effects. The use of aprepitant for HIV therapy may be limited due to its ability to cause serious liver damage when taken with other drugs that are metabolized by cytochrome P450 enzymes.

Fórmula: C₂₃H₂₁F₇N₄O₃

Pureza: Min. 98 Area-%

Peso molecular: 534.43 g/mol

Ref: 3D-BA164216

Aprepitant

CAS: 170729-80-3

Aprepitant is a neurokinin-1 receptor antagonist. It is an antiemetic which suppresses nausea and vomiting and has proven to be especially useful alongside cancer chemotherapy and as a tool in cancer-related studies. Aprepitant binds to the neurokinin-1 receptor in the brain, preventing it from binding to substance P. This prevents substance P from stimulating nerves in the vomiting center of the brain, reducing feelings of nausea and vomiting. Aprepitant has been shown to be effective against HIV infection, with no major side effects. The use of aprepitant for HIV therapy may be limited due to its ability to cause serious liver damage when taken with other drugs that are metabolized by cytochrome P450 enzymes.

Fórmula: C₂₃H₂₁F₇N₄O₃

Pureza: Min. 98%

Forma y color: White Off-White Powder

Peso molecular: 534.43 g/mol

Ref: 3D-FA17962

5-[2(R)-[1(R)-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3(S)-(4-fluorophenyl)morpholin-4-ylmethyl]-3,4-dihydro-2H-1,2,4-triazol-3-one

CAS: 170729-80-3

Pureza: 98%

Peso molecular: 534.4349976

Ref: 10-F862381

Fosaprepitant Dimeglumine Impurity C

CAS: 170729-80-3

Fórmula: C₂₃H₂₁F₇N₄O₃

Peso molecular: 534.43

Ref: ST-EA-CP-F36003