CAS 170729-80-3
:Aprepitant
Descripción:
Aprepitant es un antagonista selectivo del receptor de neuroquinina-1 (NK1), utilizado principalmente en la prevención de náuseas y vómitos asociados con la quimioterapia y la cirugía. Se clasifica como una molécula pequeña y a menudo se administra por vía oral. Aprepitant exhibe una alta afinidad por el receptor NK1, que juega un papel crucial en la respuesta emética mediada por la sustancia P, un neuropéptido involucrado en la percepción del dolor y la inflamación. La sustancia se caracteriza por su relativamente baja solubilidad en agua, lo que influye en su formulación y biodisponibilidad. Aprepitant se utiliza típicamente en combinación con otros agentes antieméticos para mejorar la eficacia terapéutica. Su farmacocinética implica un extenso metabolismo en el hígado, principalmente a través del sistema del citocromo P450, lo que puede llevar a interacciones medicamentosas. Los efectos secundarios comunes pueden incluir fatiga, mareos y trastornos gastrointestinales. En general, Aprepitant representa un avance significativo en el manejo de las náuseas y vómitos inducidos por quimioterapia, mejorando la calidad de vida de los pacientes que se someten a tratamiento contra el cáncer.
Fórmula:C23H21F7N4O3
InChI:InChI=1S/C23H21F7N4O3/c1-12(14-8-15(22(25,26)27)10-16(9-14)23(28,29)30)37-20-19(13-2-4-17(24)5-3-13)34(6-7-36-20)11-18-31-21(35)33-32-18/h2-5,8-10,12,19-20H,6-7,11H2,1H3,(H2,31,32,33,35)/t12-,19+,20-/m1/s1
Clave InChI:InChIKey=ATALOFNDEOCMKK-OITMNORJSA-N
SMILES:C(N1[C@H]([C@@H](O[C@H](C)C2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)OCC1)C3=CC=C(F)C=C3)C4=NNC(=O)N4
Sinónimos:- 3H-1,2,4-Triazol-3-one, 5-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-
- 3H-1,2,4-Triazol-3-one, 5-[[2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-, [2R-[2α(R*),3α]]-
- 5-[2(R)-[1(R)-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3(S)-(4-fluorophenyl)morpholin-4-ylmethyl]-3,4-dihydro-2H-1,2,4-triazol-3-one
- 5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,
- 5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one
- 5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one, Emend
- 5-{[(2R,3S)-2-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}-3-(4-fluorophenyl)morpholin-4-yl]methyl}-1,2-dihydro-3H-1,2,4-triazol-3-one
- Emend
- L 754030
- Mk 869
- Mk-0869
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Aprepitant
CAS:Fórmula:C23H21F7N4O3Pureza:>98.0%(HPLC)Forma y color:White to Almost white powder to crystalPeso molecular:534.43Aprepitant
CAS:AprepitantFórmula:C23H21F7N4O3Pureza:99.9%Forma y color:White. To. BeigePeso molecular:534.15019Aprepitant
CAS:Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoiFórmula:C23H21F7N4O3Forma y color:White Off-White PowderPeso molecular:534.15019Aprepitant
CAS:Fórmula:C23H21F7N4O3Pureza:(HPLC) ≥ 98.0%Forma y color:White to off-white powderPeso molecular:534.43Aprepitant Impurity 31
CAS:Fórmula:C27H24F7NO2Forma y color:White To Off-White SolidPeso molecular:527.49Aprepitant
CAS:Producto controladoApplications Aprepitant is a neurokinin-1 antagonist and an antiemetic agent (1). It is used to prevent chemotherapy-induced nausea and vomiting (CINV) in colorectal cancer patients (2) Aprepitant has also been shown to induce apoptotic cell death and G1 arrest through Akt/p53 axis in pre-B acute lymphoblastic leukemia cells (3).
References (1) Takemoto, H., et al.: nt J Clin Oncol (2016) (2) Bayati, S., et al.: Eur J Pharmacol. 791, 274 (2016) (3) Navari, R.M.: Expert Rev Anticancer Ther. 4, 715 (2004)Fórmula:C23H21F7N4O3Forma y color:NeatPeso molecular:534.435-(((2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-1H-1,2,4-triazol-3(2H)-one
CAS:5-(((2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)morpholino)methyl)-1H-1,2,4-triazol-3(2H)-oneFórmula:C23H21F7N4O3Pureza:98%Peso molecular:534.43Aprepitant
CAS:Aprepitant (Aprepitant`) is a Substance P/Neurokinin-1 Receptor Antagonist.Fórmula:C23H21F7N4O3Pureza:98% - 99.68%Forma y color:Off-White To Light Yellow Cyrstalline SolidPeso molecular:534.43Aprepitant
CAS:Aprepitant is a neurokinin-1 receptor antagonist. It is an antiemetic which suppresses nausea and vomiting and has proven to be especially useful alongside cancer chemotherapy and as a tool in cancer-related studies. Aprepitant binds to the neurokinin-1 receptor in the brain, preventing it from binding to substance P. This prevents substance P from stimulating nerves in the vomiting center of the brain, reducing feelings of nausea and vomiting. Aprepitant has been shown to be effective against HIV infection, with no major side effects. The use of aprepitant for HIV therapy may be limited due to its ability to cause serious liver damage when taken with other drugs that are metabolized by cytochrome P450 enzymes.Fórmula:C23H21F7N4O3Pureza:Min. 98%Forma y color:White Off-White PowderPeso molecular:534.43 g/molAprepitant - Bio-X ™
CAS:Aprepitant is a neurokinin-1 receptor antagonist. It is an antiemetic which suppresses nausea and vomiting and has proven to be especially useful alongside cancer chemotherapy and as a tool in cancer-related studies. Aprepitant binds to the neurokinin-1 receptor in the brain, preventing it from binding to substance P. This prevents substance P from stimulating nerves in the vomiting center of the brain, reducing feelings of nausea and vomiting. Aprepitant has been shown to be effective against HIV infection, with no major side effects. The use of aprepitant for HIV therapy may be limited due to its ability to cause serious liver damage when taken with other drugs that are metabolized by cytochrome P450 enzymes.
Fórmula:C23H21F7N4O3Pureza:Min. 98 Area-%Peso molecular:534.43 g/mol5-[2(R)-[1(R)-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3(S)-(4-fluorophenyl)morpholin-4-ylmethyl]-3,4-dihydro-2H-1,2,4-triazol-3-one
CAS:Pureza:98%Peso molecular:534.4349976
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