CAS 1792999-26-8

Fórmula: C21H21N5O2

InChI: InChI=1S/C21H21N5O2/c27-15-5-7-16(8-6-15)28-19-3-1-2-13-11-22-21(26-20(13)19)25-14-4-9-17-18(10-14)24-12-23-17/h1-4,9-12,15-16,27H,5-8H2,(H,23,24)(H,22,25,26)

Clave InChI: FYWRWBSYRGSWIQ-UHFFFAOYSA-N

SMILES: C1CC(CCC1O)OC2=CC=CC3=CN=C(N=C32)NC4=CC5=C(C=C4)N=CN5

NCB-0846

CAS: 1792999-26-8

NCB-0846

Fórmula: C₂₁H₂₁N₅O₂

Pureza: ≥95%

Peso molecular: 375.42

Ref: 54-BUP05371

cis-4-[[2-(1H-Benzimidazol-6-ylamino)-8-quinazolinyl]oxy]-cyclohexanol

CAS: 1792999-26-8

Fórmula: C₂₁H₂₁N₅O₂

Pureza: 98%

Forma y color: Solid

Peso molecular: 375.4237

Ref: IN-DA01E2UJ

Cis-4-((2-((1H-Benzo[D]Imidazol-6-Yl)Amino)Quinazolin-8-Yl)Oxy)Cyclohexanol

CAS: 1792999-26-8

Cis-4-((2-((1H-Benzo[D]Imidazol-6-Yl)Amino)Quinazolin-8-Yl)Oxy)Cyclohexanol

Pureza: 99%

Peso molecular: 375.42g/mol

Ref: 54-OR1023980

NCB-0846

CAS: 1792999-26-8

cis-4-((2-((1H-Benzo[d]imidazol-6-yl)amino)quinazolin-8-yl)oxy)cyclohexanol

Fórmula: C₂₁H₂₁N₅O₂

Pureza: 98%

Peso molecular: 375.42

Ref: IN-DG767450

NCB-0846

CAS: 1792999-26-8

NCB-0846 is an orally active TNIK inhibitor (IC50: 21 nM).

Fórmula: C₂₁H₂₁N₅O₂

Pureza: 97.04% - 99.89%

Forma y color: Solid

Peso molecular: 375.42

Ref: TM-T4011

cis-4-​[[2-​(1H-​Benzimidazol-​6-​ylamino)​-​8-​quinazolinyl]​oxy]​-​cyclohexanol

Producto controlado

CAS: 1792999-26-8

Applications cis-4-​[[2-​(1H-​Benzimidazol-​6-​ylamino)​-​8-​quinazolinyl]​oxy]​-​cyclohexanol inhibits Traf2 and Nck-interacting protein kinase (TNIK). TNIK is involved with Canonical Wnt/b-catenin signalling, which has regulatory roles in maintaining intestinal stem cells and aberration in this pathway has been implicated in colorectal carcinogenesis. TNIK is a therapeutic target.
References Masuda, M., et al.: Nat Commun. 7, 12586 (2016); Masuda, M., et al.: Pharmacol. Ther. 156, 1 (2017);

Fórmula: C₂₁H₂₁N₅O₂

Forma y color: Neat

Peso molecular: 375.42

Ref: TR-B197005

cis-4-[[2-(1H-Benzimidazol-6-ylamino)-8-quinazolinyl]oxy]-cyclohexanol

CAS: 1792999-26-8

Cis-4-[[2-(1H-benzimidazol-6-ylamino)-8-quinazolinyl]oxy]-cyclohexanol is a ligand that binds to the coxsackievirus and adenovirus receptor (CovR) and blocks its function. The CovR protein is expressed on the surface of cells in the heart, lungs, and other tissues. Cis-4-[[2-(1H-Benzimidazol-6-ylamino)-8-quinazolinyl]oxy]-cyclohexanol is a temporary antiviral agent that has been synthesized to evaluate its potential as an antiviral drug for use during a pandemic. The synthesized compound has been evaluated by analytical methods such as NMR and mass spectroscopy. These evaluations have shown that cis-4-[2-(1H benzimidazol 6 ylamino)-8 quinazolinyl]

Fórmula: C₂₁H₂₁N₅O₂

Pureza: Min. 95%

Peso molecular: 375.42 g/mol

Ref: 3D-SWC99926