CAS 187235-37-6

PA 824

Descripción:

PA-824, con el número CAS 187235-37-6, es un compuesto sintético estudiado principalmente por su posible uso en el tratamiento de la tuberculosis, particularmente en cepas resistentes a los medicamentos. Pertenece a la clase de nitroimidazoles y exhibe actividad bactericida contra Mycobacterium tuberculosis. PA-824 funciona a través de un mecanismo de acción único, donde se activa en condiciones anaeróbicas, lo que lleva a la generación de especies reactivas de nitrógeno que interrumpen los procesos celulares bacterianos. Este compuesto se caracteriza por su capacidad para penetrar eficazmente la pared celular micobacteriana, lo que lo convierte en un candidato prometedor en la terapia de la tuberculosis. Además, PA-824 ha mostrado propiedades farmacocinéticas favorables, incluyendo biodisponibilidad oral y una vida media prolongada, que apoyan su potencial para regímenes de dosificación una vez al día. La investigación continúa evaluando su eficacia y seguridad en entornos clínicos, particularmente en terapias combinadas destinadas a mejorar los resultados del tratamiento para pacientes con tuberculosis multidrogorresistente. En general, PA-824 representa un avance significativo en la búsqueda de agentes anti-tuberculosos efectivos.

Fórmula: C₁₄H₁₂F₃N₃O₅

InChI: InChI=1/C14H12F3N3O5/c15-14(16,17)25-10-3-1-9(2-4-10)7-23-11-5-19-6-12(20(21)22)18-13(19)24-8-11/h1-4,6,11H,5,7-8H2/t11-/m0/s1

Clave InChI: InChIKey=ZLHZLMOSPGACSZ-NSHDSACASA-N

SMILES: N(=O)(=O)C1=CN2C(=N1)OC[C@@H](OCC3=CC=C(OC(F)(F)F)C=C3)C2

Sinónimos:

• (6S)-2-Nitro-6-[[4-(trifluoromethoxy)phenyl]methoxy]-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine
• (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine
• (6S)-6,7-Dihydro-2-nitro-6-[[4-(trifluoromethoxy)phenyl]methoxy]-5H-imidazo[2,1-b][1,3]oxazine
• (S)-2-Nitro-6-((4-(trifluoromethoxy)benzyl)oxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine
• (S)-6-[[4-(Trifluoromethoxy)benzyl]oxy]-6,7-dihydro-2-nitro-5H-imidazo[2,1-b][1,3]oxazine
• (S)-Pa 824
• 5H-Imidazo[2,1-b][1,3]oxazine, 6,7-dihydro-2-nitro-6-[[4-(trifluoromethoxy)phenyl]methoxy]-, (6S)-
• 5H-Imidazo[2,1-b][1,3]oxazine, 6,7-dihydro-2-nitro-6-[[4-(trifluoromethoxy)phenyl]methoxy]-, (S)-
• Pa-824
• Pretomanid
• EOS-60675
• PA-824, >=98%
• PA-824;PA824;PA 824
• (6S)-6,7-Dihydro-2-nitro-6-[[4-(trifluoromethoxy)phenyl]methoxy]-5H-imidazo[2,1-b][1,3]oxazine PA-824
• 2-NITRO-6(S)-[4-(TRIFLUOROMETHOXY)BENZYLOXY]-6,7-DIHYDRO-5H-IMIDAZO[2,1-B][1,3]OXAZINE
• CS-930
• (S)-6,7-Dihydro-2-nitro-6-[[4-(trifluoromethoxy)phenyl]methoxy]-5H-imidazo[2,1-b][1,3]oxazine
• (S)-PA 824 (Pretomanid)
• (6S)-2-nitro-6-{[4-(trifluoromethoxy)phenyl]metho
• (S)-2-Nitro-6-((4-(trifluoromethoxy)benzyl)oxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine 98+%
• PRETOMANID;(S)-PA 824
• (S)-6-(4-(trifluoromethoxy)benzyloxy)-2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine
• xy}-5H,6H,7H-imidazo[2,1-b][1,3]oxazine
• PA-824(Pretomanid)

PA-824

CAS: 187235-37-6

Fórmula: C₁₄H₁₂F₃N₃O₅

Pureza: >98.0%(HPLC)

Forma y color: White to Almost white powder to crystal

Peso molecular: 359.26

Ref: 3B-P2718

Pretomanid

CAS: 187235-37-6

Pretomanid

Fórmula: C₁₄H₁₂F₃N₃O₅

Pureza: ≥98%

Forma y color: Solid

Peso molecular: 359.26

Ref: 54-BUP06246

(6S)-6,7-Dihydro-2-nitro-6-[[4-(trifluoromethoxy)phenyl]methoxy]-5H-imidazo[2,1-b][1,3]oxazine

CAS: 187235-37-6

Fórmula: C₁₄H₁₂F₃N₃O₅

Pureza: 98%

Forma y color: Solid

Peso molecular: 359.2574

Ref: IN-DA0074WJ

Pretomanid (PA-824)

CAS: 187235-37-6

Fórmula: C₁₄H₁₂F₃N₃O₅

Forma y color: White To Off-White Solid

Peso molecular: 359.26

Ref: 4Z-P-138001

(S)-2-Nitro-6-((4-(trifluoromethoxy)benzyl)oxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine

CAS: 187235-37-6

(S)-2-Nitro-6-((4-(trifluoromethoxy)benzyl)oxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine

Fórmula: C₁₄H₁₂F₃N₃O₅

Pureza: 99%

Forma y color: Solid

Peso molecular: 359.25738

Ref: 54-PC400580

PA-824

CAS: 187235-37-6

(S)-2-Nitro-6-((4-(trifluoromethoxy)benzyl)oxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine

Fórmula: C₁₄H₁₂F₃N₃O₅

Pureza: 99%

Peso molecular: 359.26

Ref: IN-DG289955

Pretomanid

CAS: 187235-37-6

Pretomanid ((S)-PA 824) , a nitroimidazole, is used as an anti-tuberculosis drug for tuberculosis with MIC less than 2.8 μM.

Fórmula: C₁₄H₁₂F₃N₃O₅

Pureza: 98.75% - 99.96%

Forma y color: Solid

Peso molecular: 359.26

Ref: TM-T6096

Pretomanid

CAS: 187235-37-6

Fórmula: C₁₄H₁₂F₃N₃O₅

Peso molecular: 359.26

Ref: ST-EA-CP-P30000

(S)-PA 824 (Pretomanid)

Producto controlado

CAS: 187235-37-6

Applications A novel anti-tuberculosis drug.
References Diacon, A.H. et al.: Antimicrob. Anents Chemother., 54, 3402 (2010); Dogra, M. et al.: Br. J. Pharmacol., 162, 226 (2010); Ginsberg, A.M. et al.: Antimicrob. Agents Chemother., 53, 3720 (2009);

Fórmula: C₁₄H₁₂F₃N₃O₅

Forma y color: Neat

Peso molecular: 359.26

Ref: TR-P122500

(S)-6,7-Dihydro-2-nitro-6-[[4-(trifluoromethoxy)phenyl]methoxy]-5H-imidazo[2,1-b][1,3]oxazine

CAS: 187235-37-6

(S)-6,7-Dihydro-2-nitro-6-[[4-(trifluoromethoxy)phenyl]methoxy]-5H-imidazo[2,1-b][1,3]oxazine ia slo known as PA-824. An anti-tuberculosis drug that affects both replicating and non-replicating Mycobacterium tuberculosis via cell wall inhibition and respiratory poisoning..

Fórmula: C₁₄H₁₂F₃N₃O₅

Pureza: Min. 98 Area-%

Forma y color: Off-White Slightly Yellow Powder

Peso molecular: 359.26 g/mol

Ref: 3D-FP26721

Pretomanid

CAS: 187235-37-6

Ref: BE-MU-7934

Pretomanid

CAS: 187235-37-6

Ref: BE-RMCP318001

(S)-2-Nitro-6-((4-(trifluoromethoxy)benzyl)oxy)-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine

CAS: 187235-37-6

Fórmula: C₁₄H₁₂F₃N₃O₅

Pureza: 98%

Forma y color: Liquid

Peso molecular: 359.261

Ref: 10-F462409

Pretomanid (Standard)

CAS: 187235-37-6

Pretomanid (Standard) is a reference standard for research and analysis in studies involving Pretomanid. Pretomanid ((S)-PA 824) , a nitroimidazole, is used as an anti-tuberculosis drug for tuberculosis with MIC less than 2.8 μM.

Fórmula: C₁₄H₁₂F₃N₃O₅

Forma y color: Solid

Peso molecular: 359.26

Ref: TM-TMSM-3604