CAS 192725-17-0: Lopinavir

Descripción: Lopinavir es un medicamento antirretroviral utilizado principalmente en el tratamiento del VIH/SIDA. Pertenece a la clase de inhibidores de la proteasa y a menudo se combina con ritonavir para mejorar su eficacia y biodisponibilidad. La fórmula química de Lopinavir es C37H48N4O5, y tiene un peso molecular de aproximadamente 628.88 g/mol. Lopinavir se caracteriza por su estructura compleja, que incluye múltiples anillos y grupos funcionales que contribuyen a su actividad farmacológica. Se administra típicamente por vía oral en forma de tabletas o solución líquida. La sustancia es conocida por su capacidad para inhibir la enzima proteasa del VIH, evitando así la replicación viral. Lopinavir generalmente es bien tolerado, pero puede tener efectos secundarios, incluidos trastornos gastrointestinales y posibles impactos en el metabolismo de lípidos. Debido a su papel en el tratamiento del VIH, Lopinavir a menudo forma parte de regímenes de terapia combinada, que pueden incluir otros agentes antirretrovirales para mejorar los resultados del tratamiento y reducir el riesgo de resistencia.

Fórmula: C₃₇H₄₈N₄O₅

InChI: InChI=1S/C37H48N4O5/c1-25(2)34(41-20-12-19-38-37(41)45)36(44)39-30(21-28-15-7-5-8-16-28)23-32(42)31(22-29-17-9-6-10-18-29)40-33(43)24-46-35-26(3)13-11-14-27(35)4/h5-11,13-18,25,30-32,34,42H,12,19-24H2,1-4H3,(H,38,45)(H,39,44)(H,40,43)/t30-,31-,32-,34-/m0/s1

Clave InChI: InChIKey=KJHKTHWMRKYKJE-SUGCFTRWSA-N

SMILES: O=C1NCCCN1C(C(=O)NC(CC=2C=CC=CC2)CC(O)C(NC(=O)COC=3C(=CC=CC3C)C)CC=4C=CC=CC4)C(C)C

Sinónimos:

• A 157378.0
• 1(2H)-Pyrimidineacetamide, N-[(1S,3S,4S)-4-[[2-(2,6-dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-α-(1-methylethyl)-2-oxo-, (αS)-
• 1(2H)-Pyrimidineacetamide, N-[(1S,3S,4S)-4-[[(2,6-dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-α-(1-methylethyl)-2-oxo-, (αS)-
• (αS)-N-[(1S,3S,4S)-4-[[2-(2,6-Dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-α-(1-methylethyl)-2-oxo-1(2H)-pyrimidineacetamide
• 1(2H)-Pyrimidineacetamide, N-[4-[[(2,6-dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-α-(1-methylethyl)-2-oxo-, [1S-[1R*(R*),3R*,4R*]]-
• ABT 378
• ABT-378
• UNII-2494G1JF75
• Kaletra
• (S)-N-((2S,4S,5S)-5-(2-(2,6-dimethylphenoxy)acetamido)-4-hydroxy-1,6-diphenylhexan-2-yl)-3-methyl-2-(2-oxotetrahydropyrimidin-1(2H)-yl)butanamide
• (1S-(1R*(R*),3R*,4R*))-N-(4-(((2,6-Dimethylphenoxy)acetyl)amino)-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl)tetrahydro-alpha-(1-methylethyl)-2-oxo-1(2H)-pyrimidineacetamide
• (2S)-N-[(2S,4S,5S)-5-{[(2,6-dimethylphenoxy)acetyl]amino}-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-oxotetrahydropyrimidin-1(2H)-yl)butanamide
• 1(2H)-Pyrimidineacetamide, N-((1S,3S,4S)-4-(((2,6-dimethylphenoxy)acetyl)amino)-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl)tetrahyrdo-alpha-1-methylethyl)-2-oxo-, (alphaS)-
• (alphaS)-Tetrahydro-N-((alphaS)-alpha-((2S,3S)-2-hydroxy-4-phenyl-3-(2-(2,6-xylyloxy)acetamido)butyl)phenethyl)-alpha-isopropyl-2-oxo-1(2H)-pyrimidineacetamide

Lopinavir

CAS: 192725-17-0

• Fórmula: C₃₇H₄₈N₄O₅
• Pureza: >98.0%(HPLC)
• Forma y color: White to Light yellow powder to crystal
• Peso molecular: 628.81

Lopinavir for peak identification CRS

CAS: 192725-17-0

• Fórmula: C₃₇H₄₈N₄O₅
• Peso molecular: 628.8008

Lopinavir for system suitability CRS

CAS: 192725-17-0

• Fórmula: C₃₇H₄₈N₄O₅
• Peso molecular: 628.8008

Lopinavir RS

CAS: 192725-17-0

Lopinavir CRS

CAS: 192725-17-0

Lopinavir

CAS: 192725-17-0

Drugs containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure

• Fórmula: C₃₇H₄₈N₄O₅
• Forma y color: White Off-White Powder
• Peso molecular: 628.36247

(αS)-N-[(1S,3S,4S)-4-[[2-(2,6-Dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-α-(1-methylethyl)-2-oxo-1(2H)-pyrimidineacetamide

CAS: 192725-17-0

• Fórmula: C₃₇H₄₈N₄O₅
• Pureza: %
• Forma y color: Solid
• Peso molecular: 628.8008

Lopinavir

CAS: 192725-17-0

• Fórmula: C₃₇H₄₈N₄O₅
• Forma y color: Off-White Solid
• Peso molecular: 628.81

Lopinavir EP Impurity H

CAS: 192725-17-0

• Fórmula: C₂₉H₃₂N₂O₄
• Forma y color: White To Off-White Solid
• Peso molecular: 472.59

Lopinavir

CAS: 192725-17-0

• Fórmula: C₃₇H₄₈N₄O₅
• Pureza: ≥ 98.0% (anhydrous basis)
• Forma y color: White crystalline powder
• Peso molecular: 628.80

Lopinavir, 98%

CAS: 192725-17-0

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. …

• Fórmula: C₃₇H₄₈N₄O₅
• Pureza: 98%
• Forma y color: White to beige, Powder
• Peso molecular: 628.81

Lopinavir

CAS: 192725-17-0

• Fórmula: C₃₇H₄₈N₄O₅
• Forma y color: Neat
• Peso molecular: 628.80

Lopinavir

CAS: 192725-17-0

• Fórmula: C₃₇H₄₈N₄O₅
• Forma y color: Neat
• Peso molecular: 628.80

Lopinavir

CAS: 192725-17-0

Lopinavir (ABT-378) is a peptidomimetic HIV protease inhibitor that retains activity against HIV protease with …

• Fórmula: C₃₇H₄₈N₄O₅
• Pureza: 98% - 99.14%
• Forma y color: White Crystalline Solid
• Peso molecular: 628.8

Lopinavir

CAS: 192725-17-0

• Pureza: 95.0%
• Forma y color: Liquid
• Peso molecular: 628.8140258789062

Lopinavir

CAS: 192725-17-0

Stability Hygroscopic Applications A selective HIV protease inhibitor. An analogue of Ritonavir. Antiviral. It is …

• Fórmula: C₃₇H₄₈N₄O₅
• Forma y color: White Solid
• Peso molecular: 628.80

Lopinavir - Bio-X ™

CAS: 192725-17-0

Chemically derived from ritonavir, Lopinavir belongs to the amphetamines. Lopinavir is clinically used in the …

• Fórmula: C₃₇H₄₈N₄O₅
• Pureza: Min. 98 Area-%
• Forma y color: Powder
• Peso molecular: 628.8 g/mol

Lopinavir

CAS: 192725-17-0

Anti-viral; HIV protease inhibitor

• Fórmula: C₃₇H₄₈N₄O₅
• Pureza: Min. 97.5 Area-%
• Forma y color: White Off-White Powder
• Peso molecular: 628.8 g/mol

N5-Des[(2,6-dimethylphenoxy)acetyl] N5-Formal Lopinavir

CAS: 192725-17-0

• Fórmula: C₂₈H₃₈N₄O₄
• Forma y color: Neat
• Peso molecular: 494.63