CAS 2079853-72-6

Fórmula: C25H25F3N8O3

InChI: InChI=1S/C25H25F3N8O3/c26-25(27,28)18-12-16(3-4-20(18)38-11-8-35-6-9-37-10-7-35)19-14-31-23-24(32-19)36(34-33-23)15-17-13-30-22-21(39-17)2-1-5-29-22/h1-5,12,14,17H,6-11,13,15H2,(H,29,30)

Clave InChI: RTJAOZQTONMFTO-UHFFFAOYSA-N

SMILES: C1COCCN1CCOC2=C(C=C(C=C2)C3=CN=C4C(=N3)N(N=N4)CC5CNC6=C(O5)C=CC=N6)C(F)(F)F

KRC-00715

CAS: 2079853-72-6

KRC-00715 is an orally effective inhibitor of c-Met, exhibiting high selectivity with an IC₅₀ of 9.0 nM. This compound specifically inhibits the growth of gastric cancer cell lines with high c-Met expression by inducing G1/S phase block, and reduces the activity of downstream signals, including Akt, Erk, and c-Met itself. In the gastric cancer cell line Hs746T, KRC-00715 demonstrates cytotoxicity with an IC₅₀ of 39 nM and selectively inhibits the proliferation of cell lines that overexpress c-Met. Additionally, KRC-00715 decreases tumor size in Hs746T xenograft mouse models.

Fórmula: C₂₅H₂₅F₃N₈O₃

Forma y color: Solid

Peso molecular: 542.51

Ref: TM-T200380