CAS 2097497-16-8

(3Z)-1,3-Dihydro-5-hydroxy-4,6-dimethyl-3-(2-quinolinylmethylene)-2H-pyrrolo[2,3-b]pyridin-2-one

Fórmula: C₁₉H₁₅N₃O₂

InChI: InChI=1S/C19H15N3O2/c1-10-16-14(19(24)22-18(16)20-11(2)17(10)23)9-13-8-7-12-5-3-4-6-15(12)21-13/h3-9,23H,1-2H3,(H,20,22,24)/b14-9-

Clave InChI: CSKXBCHNPARCGH-ZROIWOOFSA-N

SMILES: CC1=C2/C(=C/C3=NC4=CC=CC=C4C=C3)/C(=O)NC2=NC(=C1O)C

Sinónimos:

• (3Z)-1,3-Dihydro-5-hydroxy-4,6-dimethyl-3-(2-quinolinylmethylene)-2H-pyrrolo[2,3-b]pyridin-2-one

Anticancer agent 109

CAS: 2097497-16-8

Anticancer agent 109 (compound 6-15) acts as an inhibitor targeting the Gas6-Axl axis, demonstrating significant anti-cancer properties. This compound suppresses the expression of Gas6, Axl, p-PI3K, and p-AKT in cancer cells, thereby inducing G1 phase arrest and promoting apoptosis of cancer cells. Additionally, Anticancer agent 109 effectively inhibits tumor growth in nude mouse tumor-bearing models [1].

Fórmula: C₁₉H₁₅N₃O₂

Forma y color: Solid

Peso molecular: 317.34

Ref: TM-T85667