CAS 2140-76-3

2'-O-metiluridina

Descripción:

2'-O-metiluridina es un nucleósido modificado que presenta un grupo metilo unido a la posición 2' del hidroxilo del azúcar ribosa en la uridina. Esta modificación mejora la estabilidad de las moléculas de ARN y puede influir en su actividad biológica. La fórmula química de 2'-O-metiluridina es C10H13N2O5, y se clasifica como un nucleósido de pirimidina. Es soluble en agua y exhibe propiedades típicas de los nucleósidos, como la capacidad de participar en enlaces de hidrógeno y emparejamiento de bases. Este compuesto se utiliza a menudo en investigación bioquímica y aplicaciones terapéuticas, particularmente en el estudio de la estructura y función del ARN, así como en el desarrollo de agentes antivirales. La presencia del grupo metilo también puede afectar la interacción del nucleósido con enzimas y otras biomoléculas, lo que lo convierte en una herramienta valiosa en biología molecular. En general, 2'-O-metiluridina sirve como un componente importante en el campo de la química de ácidos nucleicos y tiene implicaciones en diversas aplicaciones biotecnológicas.

Fórmula: C₁₀H₁₄N₂O₆

InChI: InChI=1/C10H14N2O6/c1-17-8-7(15)5(4-13)18-9(8)12-3-2-6(14)11-10(12)16/h2-3,5,7-9,13,15H,4H2,1H3,(H,11,14,16)/t5-,7-,8-,9-/m1/s1

Clave InChI: InChIKey=SXUXMRMBWZCMEN-ZOQUXTDFSA-N

SMILES: O(C)[C@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C(=O)NC(=O)C=C2

Sinónimos:

• 2''-O-Methyluridine Crystalline
• 2'-O-Methyluridine (Chiral)
• O²′-Methyluridine
• Uridine, 2′-O-methyl-
• 2′-O-Methyluridine
• O2′-Methyluridine
• 1: PN: WO2023049218 PAGE: 366 claimed sequence
• -2'-O-METHYLURIDINE

2'-O-Methyluridine

CAS: 2140-76-3

Fórmula: C₁₀H₁₄N₂O₆

Pureza: >98.0%(HPLC)(T)

Forma y color: White to Almost white powder to crystal

Peso molecular: 258.23

Ref: 3B-M2290

2'-O-Methyluridine, 99%

CAS: 2140-76-3

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Fórmula: C₁₀H₁₄N₂O₆

Pureza: 99%

Peso molecular: 258.23

Ref: 02-J64897

2′-O-Methyluridine

CAS: 2140-76-3

2′-O-Methyluridine

Fórmula: C₁₀H₁₄N₂O₆

Pureza: 99.5%

Peso molecular: 258.23

Ref: 54-BUP16476

2'-O-Methyluridine

CAS: 2140-76-3

2'-O-Methyluridine

Fórmula: C₁₀H₁₄N₂O₆

Pureza: >99%

Forma y color: Solid

Peso molecular: 258.22796

Ref: 54-OR60199

2''-O-Methyl uridine

CAS: 2140-76-3

Fórmula: C₁₀H₁₄N₂O₆

Peso molecular: 258.23

Ref: 7W-GC2862

1-((2R,3R,4R,5R)-4-Hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

CAS: 2140-76-3

Fórmula: C₁₀H₁₄N₂O₆

Pureza: 98%

Forma y color: Solid

Peso molecular: 258.2280

Ref: IN-DA0037V3

2'-O-Methyl Uridine-d3

Producto controlado

CAS: 2140-76-3

Applications 2'-O-Methyl Uridine-d3 is an isotope labelled compound of 2'-O-Methyl Uridine (M338200), a uridine analog used for the preparation of antiviral nucleoside derivatives as inhibitors of subgenomic hepatitis C virus RNA replication.
References Gratzner, H., et al.: Science, 218, 474 (1982), Jarvis, T., et al.: J. Biol. Chem., 271, 29107 (1996), Pavco, P., et al.: Clin. Cancer Res., 6, 2094 (2000),

Fórmula: C₁₀D₃H₁₁N₂O₆

Forma y color: Neat

Peso molecular: 261.246

Ref: TR-M338202

2'-O-Methyluridine

CAS: 2140-76-3

Fórmula: C₁₀H₁₄N₂O₆

Peso molecular: 258.23

Ref: 4Z-U-0151

2′-O-Methyluridine

CAS: 2140-76-3

2′-O-Methyluridine is a natural product that found in RNA such as rRNA, snRNA, snoRNA and tRNA in Archaea, Bacteria, and Eukaryota.

Fórmula: C₁₀H₁₄N₂O₆

Pureza: 99.6%

Forma y color: Solid

Peso molecular: 258.228

Ref: TM-TN7106

1-((2R,3R,4R,5R)-4-Hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

CAS: 2140-76-3

Fórmula: C₁₀H₁₄N₂O₆

Pureza: 95%

Forma y color: Solid

Peso molecular: 258.23

Ref: 10-F212232

2′-O-Methyluridine

CAS: 2140-76-3

1-((2R,3R,4R,5R)-4-Hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

Fórmula: C₁₀H₁₄N₂O₆

Pureza: 98%

Peso molecular: 258.23

Ref: IN-DG8116

2'-O-Methyl Uridine

Producto controlado

CAS: 2140-76-3

Applications Uridine analog. Used for preparation of antiviral nucleoside derivatives as inhibitors of subgenomic hepatitis C virus RNA replication.
References Gratzner, H., et al.: Science, 218, 474 (1982), Jarvis, T., et al.: J. Biol. Chem., 271, 29107 (1996), Pavco, P., et al.: Clin. Cancer Res., 6, 2094 (2000),

Fórmula: C₁₀H₁₄N₂O₆

Forma y color: Neat

Peso molecular: 258.23

Ref: TR-M338200

2'-O-Methyluridine

CAS: 2140-76-3

2'-O-Methyluridine is a chemical compound that is used in the synthesis of RNA. It is an analog of uridine and has been shown to have antiviral and anticancer properties. 2'-O-Methyluridine inhibits protein synthesis by competing with uridine for the active site of the enzyme ribonucleotide reductase, which converts ribonucleotides to dNMPs. This compound also inhibits RNA synthesis by disrupting the pairing of adenine and cytosine residues in RNA strands. 2'-O-Methyluridine has been shown to inhibit growth in some types of cancer cells, including colorectal adenocarcinoma cells. It may also be useful as a chemotherapeutic agent against HIV, as it inhibits virus replication by inhibiting reverse transcription and DNA synthesis.

Fórmula: C₁₀H₁₄N₂O₆

Pureza: Min. 98 Area-%

Forma y color: White Off-White Powder

Peso molecular: 258.23 g/mol

Ref: 3D-NM04259