CAS 219138-18-8

Fórmula: C29H37N7O6

InChI: InChI=1S/C29H37N7O6/c30-22-8-2-1-7-21(22)26(37)32-16-4-3-9-23(31)28(39)35-18-6-11-25(35)29(40)34-17-5-10-24(34)27(38)33-19-12-14-20(15-13-19)36(41)42/h1-2,7-8,12-15,23-25H,3-6,9-11,16-18,30-31H2,(H,32,37)(H,33,38)/t23-,24-,25-/m0/s1

Clave InChI: PYDKOXBAMHOEAF-SDHOMARFSA-N

SMILES: C1C[C@H](N(C1)C(=O)[C@@H]2CCCN2C(=O)[C@H](CCCCNC(=O)C3=CC=CC=C3N)N)C(=O)NC4=CC=C(C=C4)[N+](=O)[O-]

H-Lys(Abz)-Pro-Pro-pNA

CAS: 219138-18-8

H-Lys(Abz)-Pro-Pro-pNA is a potent and selective DPP-IV inhibitor that has been shown to be active in humans. This drug binds to the DPP-IV enzyme and prevents it from breaking down the incretin hormone, GLP-1, which is released by the intestine in response to food intake. This leads to increased insulin production and an improved glycemic profile in people with type 2 diabetes. H-Lys(Abz)-Pro-Pro-pNA also inhibits endoproteolysis of dipeptidyl peptidase IV (DPPIV), which reduces its activity against other enzymes such as amyloid beta protein precursor protein (APP) and angiotensin II receptor type 1 (AT1R).

Fórmula: C₂₉H₃₇N₇O₆

Pureza: Min. 95%

Peso molecular: 579.65 g/mol

Ref: 3D-FL110802

H-Lys(Abz)-Pro-Pro-pNA

CAS: 219138-18-8

Internally quenched fluorogenic (FRET) substrate which allows aminopeptidase P (APP) activity determination by a continuous fluorescent assay (kcat/Km = 29’000 M⁻¹s⁻¹ for E.coli APP and kcat/Km = 1’142’000 M⁻¹s⁻¹ for rat APP).

Fórmula: C₂₉H₃₇N₇O₆

Pureza: 95.8%

Forma y color: Light Yellow Lyophilisate

Peso molecular: 579.66

Ref: 01-4027668