CAS 2209085-22-1

Fórmula: C53H69N5O9

InChI: InChI=1S/C53H69N5O9/c1-52-19-15-38(32-37(52)9-10-39-42-12-11-41(53(42,2)20-16-43(39)52)35-8-7-34-17-21-54-33-36(34)31-35)57(3)47(60)18-23-64-25-27-66-29-30-67-28-26-65-24-22-55-44-6-4-5-40-48(44)51(63)58(50(40)62)45-13-14-46(59)56-49(45)61/h4-8,17,21,31,33,37-39,41-43,45,55H,9-16,18-20,22-30,32H2,1-3H3,(H,56,59,61)/t37-,38-,39-,41+,42-,43-,45?,52-,53+/m0/s1

Clave InChI: JECHBTRAPARMGI-GFTKVEOVSA-N

SMILES: C[C@]12CC[C@@H](C[C@@H]1CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CC[C@@H]4C5=CC6=C(C=C5)C=CN=C6)C)N(C)C(=O)CCOCCOCCOCCOCCNC7=CC=CC8=C7C(=O)N(C8=O)C9CCC(=O)NC9=O

N-[(1S,3aS,3bR,5aS,7S,9aS,9bS,11aS)-1-(isoquinolin-7-yl)-9a,11a-dimethyl-hexadecahydro-1H-cyclopenta[a]phenanthren-7-yl]-1-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}-N

CAS: 2209085-22-1

N-[(1S,3aS,3bR,5aS,7S,9aS,9bS,11aS)-1-(isoquinolin-7-yl)-9a,11a-dimethyl-hexadecahydro-1H-cyclopenta[a]phenanthren-7-yl]-1-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}-N

Fórmula: C₅₃H₆₉N₅O₉

Pureza: 99.82%

Peso molecular: 920.14

Ref: 54-OR1120058

N-[(1S,3aS,3bR,5aS,7S,9aS,9bS,11aS)-1-(isoquinolin-7-yl)-9a,11a-dimethyl-hexadecahydro-1H-cyclopenta[a]phenanthren-7-yl]-1-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}-N-methyl-3,6,9,12-tetraoxapentadecan-15-amide

CAS: 2209085-22-1

Fórmula: C₅₃H₆₉N₅O₉

Pureza: 99.82%

Peso molecular: 920.1431

Ref: IN-DA01NASW

JH-XI-10-02

CAS: 2209085-22-1

JH-XI-10-02 selectively degrades CDK8 (IC50: 159 nM) through proteasome, sparing CDK8 mRNA and CDK19.

Fórmula: C₅₃H₆₉N₅O₉

Pureza: 98%

Forma y color: Solid

Peso molecular: 920.161

Ref: TM-T13743

Jh-xi-10-02

CAS: 2209085-22-1

Jh-xi-10-02 is a heterobifunctional molecule that inhibits ubiquitin ligases and targets cancer cells. It is an inhibitor of the ubiquitin-proteasome pathway, which is a cellular pathway that degrades and recycles proteins. Jh-xi-10-02 prevents the degradation of cortistatin, leading to increased levels of this protein in mammalian cells. This drug also has pharmacokinetic properties and can be synthesized without toxicities. Jh-xi-10-02 has been shown to inhibit the growth of cancer cells in culture and in animal models, suggesting it may be a potential anticancer agent.

Fórmula: C₅₃H₆₉N₅O₉

Pureza: Min. 95%

Peso molecular: 920.14 g/mol

Ref: 3D-JND08522