CAS 2222354-29-0

Fórmula: C54H68ClN11O9S2

InChI: InChI=1S/C54H68ClN11O9S2/c1-34-11-8-16-40(55)47(34)62-51(70)43-31-57-54(77-43)61-44-30-45(59-36(3)58-44)64-19-21-65(22-20-64)46(67)32-74-26-25-72-23-24-73-27-28-75-39-15-9-14-38(29-39)49(68)41-33-76-52(60-41)42-17-10-18-66(42)53(71)48(37-12-6-5-7-13-37)63-50(69)35(2)56-4/h8-9,11,14-16,29-31,33,35,37,42,48,56H,5-7,10,12-13,17-28,32H2,1-4H3,(H,62,70)(H,63,69)(H,57,58,59,61)/t35-,42-,48-/m0/s1

Clave InChI: PLCDNLSIFCGNNG-GFKCZKLESA-N

SMILES: CC1=C(C(=CC=C1)Cl)NC(=O)C2=CN=C(S2)NC3=CC(=NC(=N3)C)N4CCN(CC4)C(=O)COCCOCCOCCOC5=CC=CC(=C5)C(=O)C6=CSC(=N6)[C@@H]7CCCN7C(=O)[C@H](C8CCCCC8)NC(=O)[C@H](C)NC

SNIPER(ABL)-039

CAS: 2222354-29-0

SNIPER(ABL)-039, conjugating Dasatinib (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of

Fórmula: C₅₄H₆₈ClN₁₁O₉S₂

Pureza: 98%

Forma y color: Solid

Peso molecular: 1114.77

Ref: TM-T18690

SNIPER(ABL)-039

CAS: 2222354-29-0

SNIPER(ABL)-039 is a heterobifunctional chemical compound, which is a synthetic molecule manufactured through advanced organic synthesis techniques. This compound functions by specifically targeting and binding to aberrant BCR-ABL fusion proteins, utilizing a protein degradation pathway. It operates through the proteolysis-targeting chimera (PROTAC) mechanism, whereby it recruits E3 ubiquitin ligase to the target protein, leading to its ubiquitination and subsequent proteasomal degradation.

Fórmula: C₅₄H₆₈ClN₁₁O₉S₂

Pureza: Min. 95%

Peso molecular: 1,114.8 g/mol

Ref: 3D-XND35429