CAS 23720-80-1
:Nardosinona
Descripción:
Nardosinona es un compuesto sesquiterpeno natural derivado principalmente de la planta Nardostachys jatamansi, comúnmente conocida como espikenardo. Se caracteriza por su compleja estructura bicíclica, que contribuye a sus propiedades químicas únicas. Nardosinona exhibe una variedad de actividades biológicas, incluyendo efectos antiinflamatorios, antimicrobianos y potenciales efectos neuroprotectores, lo que lo hace de interés en la investigación farmacológica. El compuesto se encuentra típicamente en aceites esenciales y extractos de la planta, y su presencia a menudo se asocia con prácticas medicinales tradicionales. En términos de solubilidad, Nardosinona es generalmente más soluble en disolventes orgánicos que en agua, lo cual es común para muchos terpenoides. Su estructura molecular incluye múltiples grupos funcionales que pueden participar en diversas reacciones químicas, mejorando sus aplicaciones potenciales tanto en la química de productos naturales como en el desarrollo terapéutico. En general, Nardosinona representa un compuesto significativo dentro del ámbito de los productos naturales, con estudios en curso destinados a elucidar su rango completo de efectos biológicos y usos potenciales en medicina.
Fórmula:C15H22O3
InChI:InChI=1S/C15H22O3/c1-9-6-5-7-10-11(16)8-12-13(15(9,10)4)14(2,3)18-17-12/h7,9,12-13H,5-6,8H2,1-4H3/t9-,12-,13+,15+/m1/s1
Clave InChI:InChIKey=KXGHHSIMRWPVQM-JWFUOXDNSA-N
SMILES:C[C@@]12[C@]3([C@@](CC(=O)C1=CCC[C@H]2C)(OOC3(C)C)[H])[H]
Sinónimos:- (3aR,9R,9aR,9bS)-1,1,9,9a-tetramethyl-1,3a,4,7,8,9,9a,9b-octahydro-5H-naphtho[2,1-c][1,2]dioxol-5-one
- (3aR,9R,9aR,9bS)-1,3a,4,7,8,9,9a,9b-Octahydro-1,1,9,9a-tetramethyl-5H-naphtho[2,1-c][1,2]dioxol-5-one
- 5H-Naphtho[2,1-c][1,2]dioxol-5-one, 1,3a,4,7,8,9,9a,9b-octahydro-1,1,9,9a-tetramethyl-, (3aR,9R,9aR,9bS)-
- 5H-Naphtho[2,1-c][1,2]dioxol-5-one, 1,3a,4,7,8,9,9a,9b-octahydro-1,1,9,9a-tetramethyl-, [3aR-(3aα,9α,9aα,9bα)]-
- Nardosinon
- Nardosinone
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(3aR,9R,9aR,9bS)-1,1,9,9a-Tetramethyl-3a,4,7,8,9,9a-hexahydro-1H-naphtho[2,1-c][1,2]dioxol-5(9bH)-one
CAS:Fórmula:C15H22O3Pureza:99%Forma y color:SolidPeso molecular:250.3334Nardosinone
CAS:Nardosinone is an enhancer of nerve growth factor and possesses a wide range of pharmacological effects, including sedative, adaptogen-like, anti-depressive, anti-leukemic, anti-tumorous, and anti-trypanosomal activities. It has a wide spectrum of targets including PI3K,Akt,MEK,ERK, PKA, MAPK.Fórmula:C15H22O3Pureza:95%~99%Peso molecular:250.338Nardosinone (Standard)
CAS:Nardosinone (Standard) is a reference standard for research and analysis in studies involving Nardosinone. 1. Nardosinone has inhibitory effect on Ang II-induced hypertrophy in H9c2 cells, might be mediated by targeting PI3K/Akt and MEK/ERK signaling pathways. 2. Nardosinone could protect against the neuronal injury exposed to OGD, which may be relevant to the promotion of PKA and ERK signaling pathway. 3. Nardosinone enhances staurosporine- or dbcAMP-induced neurite outgrowth from PC12D cells, probably by amplifying both the MAP kinase-dependent and -independent signaling pathways of dbcAMP and staurosporine. 4. The enhancement of NGF-induced neurite outgrowth from PC12D cells by Nardosinone involves activation of a down-stream step of the MAP kinase-dependent cascade of NGF coupled with PKC.Fórmula:C15H22O3Peso molecular:250.3334Nardosinone
CAS:Producto controladoApplications Nardosinone reduces neuronal injury and protects H9c2 cardiac cells from angiotensin II-induced hypertrophy which may give rise to heart failure. Enhancer of nerve growth factor (NGF).
References Du, M. et al.: J. Huazhong Uni. Sci. Tech. Med. Serv., 33, 822 (2013); Li, P. et al.: Dev. Brain Res., 145, 177 (2003);Fórmula:C15H22O3Forma y color:NeatPeso molecular:250.33(3aR,9R,9aR,9bS)-1,1,9,9a-Tetramethyl-3a,4,7,8,9,9a-hexahydro-1H-naphtho[2,1-c][1,2]dioxol-5(9bH)-one
CAS:Fórmula:C15H22O3Pureza:99%Peso molecular:250.33Nardosinone
CAS:Nardosinone inhibits H9c2 cell hypertrophy, protects neurons from OGD, and boosts neurite outgrowth by modifying key signaling pathways.Fórmula:C15H22O3Pureza:98.82% - 99%Forma y color:SolidPeso molecular:250.3334Nardosinone
CAS:Oxygen-heterocyclic compoundFórmula:C15H22O3Pureza:≥ 98.0 % (HPLC)Forma y color:CrystalsPeso molecular:250.34Nardosinone
CAS:Producto controladoNardosinone is a secoiridoid compound, which is a natural product derived from the roots of the plant Nardostachys jatamansi, commonly known as spikenard. The source of Nardosinone is a flowering plant that is native to the Himalayan region and has been traditionally used in Ayurvedic medicine for its therapeutic properties. The mode of action of Nardosinone involves modulation of neurotransmitter systems, inhibition of neuroinflammation, and protection against oxidative damage, contributing to its neuroprotective effects. Nardosinone exhibits potential applications in the treatment of neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease, due to its ability to improve cognitive function and mitigate neuronal damage. Additionally, it is being investigated for its potential role in mood regulation and anti-anxiety effects. Given its intriguing pharmacological profile, Nardosinone is the subject of ongoing research aimed at understanding its comprehensive mechanisms and potential therapeutic benefits in neuroscience.Fórmula:C15H22O3Pureza:Min. 95%Forma y color:SolidPeso molecular:250.33 g/mol
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