CAS 2421119-78-8

Fórmula: C23H25F3N4O6

InChI: InChI=1S/C21H24N4O4.C2HF3O2/c26-19(25-29)6-4-2-1-3-5-10-23-20-16-9-11-22-13-17(16)15-8-7-14(21(27)28)12-18(15)24-20;3-2(4,5)1(6)7/h7-9,11-13,29H,1-6,10H2,(H,23,24)(H,25,26)(H,27,28);(H,6,7)

Clave InChI: RXGZVKUYAJCHEV-UHFFFAOYSA-N

SMILES: C1=CC2=C(C=C1C(=O)O)N=C(C3=C2C=NC=C3)NCCCCCCCC(=O)NO.C(=O)(C(F)(F)F)O

IOR-160

CAS: 2421119-78-8

IOR-160 is a dual inhibitor of casein kinase 2 (CK2) and HDAC. It exhibits high selectivity for CK2 with an IC50 of 1.7 nM and demonstrates broad inhibitory activity against HDAC (HDAC1, 2, 3, and 6) with IC50 values of 3.3 nM, 24.0 nM, 3.9 nM, and 13.0 nM, respectively, while showing low activity against HDAC8. IOR-160 modulates critical cell signaling pathways by inhibiting AKT phosphorylation and increasing α-tubulin acetylation. The compound reduces tumor growth and burden through its dual inhibition of CK2/HDAC and is relevant for research on triple-negative breast cancer.

Fórmula: C₂₃H₂₅F₃N₄O₆

Forma y color: Solid

Peso molecular: 510.46

Ref: TM-T211840