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CAS 2504949-52-2

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    DGY-09-192

    CAS:
    DGY-09-192 is a PROTAC FGFR1/2 degrader with DC50 values of 4.35 nM for FGFR1 and 70 nM for FGFR2. It selectively degrades wild-type FGFR1/2 and various FGFR2 fusion proteins, including FGFR2-PHGDH and FGFR2-OPTN. In both in vitro and in vivo studies, DGY-09-192 inhibits downstream FGFR signaling pathways by reducing the phosphorylation of FRS2Y196 and ERK1/2T202/Y204.
    Fórmula:C49H59Cl2N11O7S
    Peso molecular:1017.04

    Ref: TM-T215174

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