CAS 25316-40-9
:Clorhidrato de doxorrubicina
Descripción:
Clorhidrato de doxorrubicina es un antibiótico antraciclínico comúnmente utilizado en la quimioterapia del cáncer. Se caracteriza por su color rojo brillante y es conocido por su potente actividad antitumoral. El compuesto actúa intercalando el ADN, inhibiendo así la síntesis de ácidos nucleicos y perturbando la replicación de las células cancerosas. La doxorubicina es soluble en agua y presenta un perfil de solubilidad dependiente del pH, lo cual es importante para su formulación y administración. Su mecanismo de acción también implica la generación de radicales libres, contribuyendo a sus efectos citotóxicos. Sin embargo, el uso de doxorubicina está asociado con varios efectos secundarios, incluida la cardiotoxicidad, que limita su dosis acumulativa. Se administra típicamente por vía intravenosa y a menudo se utiliza en combinación con otros agentes quimioterapéuticos para mejorar la eficacia contra diversas malignidades, incluyendo el cáncer de mama, leucemia y linfomas. Debido a sus significativos beneficios terapéuticos y riesgos potenciales, el monitoreo y manejo cuidadosos son esenciales durante el tratamiento.
Fórmula:C27H29NO11·ClH
InChI:InChI=1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22+,27-;/m0./s1
Clave InChI:InChIKey=MWWSFMDVAYGXBV-RUELKSSGSA-N
SMILES:OC=1C2=C([C@@H](O[C@H]3C[C@H](N)[C@H](O)[C@H](C)O3)C[C@@](C(CO)=O)(O)C2)C(O)=C4C1C(=O)C=5C(C4=O)=C(OC)C=CC5.Cl
Sinónimos:- (1S,3S)-3,5,12-trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside hydrochloride (1:1)
- (1S,3S)-3,5,12-trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxyhexopyranoside hydrochloride (1:1)
- (8S-Cis)-10-((3-Amino-2,3,6-Trideoxy-Alpha-L-Lyxo-Hexopyranosyl)Oxy)-7,8,9,10-Tetrahydro-6,8,11-Trihydroxy-8-(Hydroxyacetyl)-1-Methoxynaphthacene-5,12-Dione Hydrochloride
- (8S-cis)-10-[(3-Amino-2,3,6-tridesoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacen-5,12-dionhydrochlorid
- (8S-cis)-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacene-5,12-dione hydrochloride
- (8S-cis)-10-[(3-amino-2,3,6-tridesoxi-α-L-lyxo-hexopiranosil)oxi]-7,8,9,10-tetrahidro-6,8,11-trihidroxi-8-(hidroxiacetil)-1-metoxinaftaceno-5,12-diona, clorhidrato
- (8S-cis)-10-[(3-amino-2,3,6-tridesoxy-α-L-lyxo-hexopyrannosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphtacene-5,12-dione, chlorhydrate
- 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-, hydrochloride (1:1), (8S,10S)-
- 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S,10S)-
- 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-<span class="text-smallcaps">L</span>-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S-cis)-
- 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-, hydrochloride (1:1), (8S,10S)-
- 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S,10S)-
- 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S-cis)-
- ADM hydrochloride
- ADR
- Adriablastina CS
- Adriacin
- Adriamycin
- Adriamycin, hydrochloride
- Adriblastin
- Adriblastina
- Adriblastina RD
- Adrosal
- Ameisu hydrochloride
- Caelyx pegylated liposomal
- DOX HCl
- Doxolipad
- Doxorubicin, HCl
- Doxorubicin-LANS
- Doxorubicin-TEVA
- Doxourbicin HCl
- Fi 106
- Fi 6804
- Hydroxydaunorubicin hydrochloride
- Lipo-Dox
- Lipodox
- Myocet liposomal
- Ver más sinónimos
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Doxorubicin hydrochloride
CAS:Doxorubicin hydrochloride, 25316-40-9, also known as Lipodox, is an anthracycline antibiotic with anti-cancer properties. Learn more at Thermo Fisher Scientific.Fórmula:C27H30ClNO11Forma y color:Crystalline powder or granular, Red to orangePeso molecular:579.98Doxorubicin hydrochloride
CAS:Doxorubicin hydrochlorideFórmula:C27H29NO11HClPureza:99.0%Forma y color:Orange To Dark RedPeso molecular:579.15074DOXORUBICIN HYDROCHLORIDE CRS
CAS:DOXORUBICIN HYDROCHLORIDE CRSFórmula:C27H29NO11Forma y color:Crystalline Powder. Orange. Red. Powder.Peso molecular:543.5193DOXORUBICIN HYDROCHLORIDE RS
CAS:DOXORUBICIN HYDROCHLORIDE RSFórmula:C27H29NO11Peso molecular:543.5193Doxorubicin Hydrochloride
CAS:Antibiotics nesoiFórmula:C27H29NO11·ClHForma y color:Red Orange Crystalline Powder Amorphous PowderPeso molecular:579.15074(8S-cis)-10-[(3-Amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacene-5,12-dione hydrochloride
CAS:Fórmula:C27H30ClNO11Pureza:98%Forma y color:SolidPeso molecular:579.9802Doxorubicin hydrochloride
CAS:Doxorubicin hydrochlorideFórmula:C27H29NO11·ClHPureza:99%Forma y color:Orange-red SolidPeso molecular:579.98019Doxorubicin hydrochloride
CAS:Doxorubicin hydrochloride (Adriamycin) belongs to the anthracycline class of antibiotics and is an inhibitor of human DNA topoisomerase I/II (IC50=0.8/2.67 μM).Fórmula:C27H29NO11·HClPureza:98% - 99.99%Forma y color:Orange-Red At Neutral Phs And Violet Blue Over Ph 9 (Ntp 1992)Peso molecular:579.99Doxorubicin hydrochloride
CAS:Doxorubicin hydrochlorideFórmula:C27H29NO11·HClPureza:≥98%Forma y color:SolidPeso molecular:579.99Doxorubicin HCl (Daunorubicin EP Impurity D HCl, Epirubicin EP Impurity C HCl)
CAS:Fórmula:C27H29NO11·HClForma y color:Red SolidPeso molecular:543.53 36.46Doxorubicin hydrochloride, 98%
CAS:Fórmula:C27H29NO11·HClPureza:(HPLC) 98.0 - 102.0 % (anhydrous, solvent free)Forma y color:Orange-red to red crystalline powderPeso molecular:579.99Doxorubicin hydrochloride, USP grade
CAS:Fórmula:C27H29NO11·HClPureza:≥ 98.0% (anhydrous, solvent-free)Forma y color:Orange-red to red crystalline powderPeso molecular:579.99Doxorubicin Hydrochloride
CAS:Producto controladoFórmula:C27H29NO11·ClHForma y color:NeatPeso molecular:579.98Doxorubicin-13C-d3 HCl (Daunorubicin EP Impurity D-13C-d3 HCl, Epirubicin EP Impurity C-13C-d3 HCl)
CAS:Fórmula:C13C22H26D3NO11·HClPeso molecular:547.56 36.45Doxorubicin Hydrochloride
CAS:Stability Hygroscopic, Light Sensitive
Applications Doxorubicin Hydrochloride is an antineoplastic agent.
References Di Marco, A., et al.: Cancer Chemother. Rep., (part 1), 53, 33 (1969); Mihich, E. and Ehrke, M.J.: Transplant. Proc., 16, 499 (1984);Fórmula:C27H29NO11·ClHForma y color:NeatPeso molecular:579.98Doxorubicin hydrochloride
CAS:Doxorubicin is a cytotoxic drug that belongs to the class of anthracyclines. It is used as an anticancer agent and in the treatment of various types of cancer. Doxorubicin has been shown to inhibit glucose uptake by cells, which may be due to its ability to form disulfide bonds with proteins. Doxorubicin also binds to iron-sulfur clusters, causing cell lysis, which may lead to tumor necrosis. In vitro assays have shown that doxorubicin inhibits drug transporter function, leading to reduced cellular uptake of drugs.Fórmula:C27H29NO11•HClPureza:Min. 95%Peso molecular:579.98 g/molDoxorubicin hydrochloride - Bio-X ™
CAS:Doxorubicin hydrochloride is an inhibitor of topoisomerase II with anti-neoplastic activity and belongs to the class of anthracyclines. It is cytotoxic, and interferes with the topoisomerase II-mediated repair of DNA causing accumulation of mutations. Doxorubicin also leads to the generation of reactive oxygen species (ROS), which further damages DNA as well as proteins and membranes. Doxorubicin is used as a chemotherapy treatment for various types of cancer, including breast cancer, lung cancer, ovarian cancer, and leukaemia. However, the compound presents with a risk of developing cardiomyopathy as well as drug resistance.Fórmula:C27H29NO11•HClPureza:Min. 95%Forma y color:PowderPeso molecular:579.98 g/molDoxorubicin HCl
CAS:Doxorubicin (DOX) is an antineoplastic chemotherapy drug used to treat breast, ovarian and pancreatic cancers. It is an antitumor antibiotic that inhibits DNA topoisomerase II. DOX interferes with the topoisomerase II-mediated repair of DNA causing accumulation of mutations. It also leads to the generation of reactive oxygen species (ROS), which further damage DNA as well as proteins and membranes. However, the compound presents with a risk of developing cardiomyopathy as well as drug resistance. Pegylated liposomal doxorubicin has also been developed to treat breast and ovarian cancers, myeloma, and HIV-related Kaposi’s sarcoma.Fórmula:C27H29NO11·HClPureza:Min. 98 Area-%Forma y color:Red PowderPeso molecular:579.98 g/mol
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