CAS 25812-30-0

gemfibrozilo

Descripción:

gemfibrozilo es un medicamento que se utiliza principalmente para reducir los niveles de lípidos en pacientes con hiperlipidemia, particularmente para reducir los triglicéridos y aumentar el colesterol de lipoproteínas de alta densidad (HDL). Pertenece a la clase de medicamentos conocidos como fibratos y actúa activando el receptor alfa activado por proliferadores de peroxisomas (PPARα), lo que mejora la oxidación de ácidos grasos y disminuye la producción de triglicéridos en el hígado. Químicamente, gemfibrozilo se caracteriza por su fórmula molecular, que incluye átomos de carbono, hidrógeno y oxígeno, y tiene una configuración estructural específica que contribuye a su actividad farmacológica. La sustancia se administra típicamente por vía oral y se absorbe bien en el tracto gastrointestinal. Su farmacocinética implica un metabolismo extenso en el hígado, principalmente a través de la glucuronidación, y tiene una vida media relativamente larga, lo que permite una dosificación dos veces al día. Los efectos secundarios comunes pueden incluir trastornos gastrointestinales, y está contraindicado en pacientes con enfermedad hepática o renal severa. Al igual que con cualquier medicamento, es esencial monitorear los niveles de lípidos y las posibles interacciones medicamentosas durante el tratamiento.

Fórmula: C₁₅H₂₂O₃

InChI: InChI=1/C15H22O3/c1-11-6-7-12(2)13(10-11)18-9-5-8-15(3,4)14(16)17/h6-7,10H,5,8-9H2,1-4H3,(H,16,17)

Clave InChI: InChIKey=HEMJJKBWTPKOJG-UHFFFAOYSA-N

SMILES: O(CCCC(C(O)=O)(C)C)C1=C(C)C=CC(C)=C1

Sinónimos:

• 2,2-Dimethyl-5-(2,5-dimethylphenoxy)pentanoic acid
• 2,2-Dimethyl-5-(2,5-dimethylphenoxy)valeriansaeure
• 2,2-Dimethyl-5-(2,5-xylyloxy)valeriansaeure
• 2,2-Dimethyl-5-(2,5-xylyloxy)valeric acid
• 5-(2,5-Dimethylphenoxy)-2,2-dimethylpentanoic acid
• 5-[(2,5-Dimethylphenyl)oxy]-2,2-dimethylpentanoic acid
• Apo-Gemfibrozil
• Ausgem
• Bolutol
• Brn 1881200
• Brozil
• Ccris 318
• Cholespid
• Ci 719
• Clearol
• Decrelip
• Elmogan
• Fetinor
• Fibratol
• Fibrocit
• Gem-S
• Gemd
• Gemfibril
• Gemfibromax
• Gemfibrozil [USAN:INN:BAN]
• Gemfibrozilo
• Gemfibrozilo [INN-Spanish]
• Gemfibrozilum
• Gemfibrozilum [INN-Latin]
• Gemlipid
• Gemnpid
• Genlip
• Gevilon
• Gevilon Uno
• Gozid
• Hidil
• Hipolixan
• Hsdb 7735
• Innogen
• Ipolipid
• Jezil
• Lanaterom
• Lifibron
• Lipazil
• Lipigem
• Lipira
• Lipizyl
• Lipur
• Litarek
• Lopid
• Lopizid
• Low-Lip
• Micolip
• Normolip
• Pentanoic acid, 5-(2,5-dimethylphenoxy)-2,2-dimethyl-
• Pilder
• Polyxit
• Progemzal
• Reducel
• Regulip
• Renabrazin
• Sinelip
• Synbrozil
• Taborcil
• Tentroc
• Trialmin
• Trialmin 900
• Unii-Q8X02027X3
• Valeric acid, 2,2-dimethyl-5-(2,5-xylyloxy)-
• WL-Gemfibrozil
• Gemfibrozil
• 5-(2,5-DIMETHYLPHENOXY)-2,2-DIMETHYLPENTANOICACID(GEMFIBROZIL)
• GEMFIBROZIL,USP
• 2,2-DIMETHYL-5-[2,5-DIMETHYL-PHENOXY]PENTANOIC ACID
• 5-(2,5-dimethylphenoxy)-2,2-dimethyl-pentanoicaci
• 5-(2,5-DIMETHYLPHYLPHENOXY)-2,2-DIMETHYLPENTANOIC ACID
• Lipozid
• 2,2-dimethyl-5-(2,5-xylyloxy)-valericaci
• 5-(2,5-Dimethylphenoxy)-2,2-dimethylpentanoic Acid, CI-719, Decrelip, Genlip, Gevilon, Lipozid, Lpur, Lopid
• Gemcitabine intermediates
• 5-(2,5-Dimethylphenoxy)-2,2-DimethylpentamoicAcid
• 2,2-Dimethyl-5-(2,5-Dimethylphenoxy)Valeric
• CI-7

Gemfibrozil

CAS: 25812-30-0

Fórmula: C₁₅H₂₂O₃

Pureza: >98.0%(GC)(T)

Forma y color: White to Almost white powder to crystal

Peso molecular: 250.34

Ref: 3B-G0368

GEMFIBROZIL FOR SYSTEM SUITABILITY CRS

CAS: 25812-30-0

GEMFIBROZIL FOR SYSTEM SUITABILITY CRS

Fórmula: C₁₅H₂₂O₃

Peso molecular: 250.3334

Ref: 41-Y0000514

GEMFIBROZIL CRS

CAS: 25812-30-0

GEMFIBROZIL CRS

Fórmula: C₁₅H₂₂O₃

Forma y color: Added Modified

Peso molecular: 250.3334

Ref: 41-Y0000513

Gemfibrozil

CAS: 25812-30-0

Gemfibrozil

Fórmula: C₁₅H₂₂O₃

Pureza: 99.9%

Forma y color: White Solid

Peso molecular: 250.15689

Ref: 47-363

Gemfibrozil

CAS: 25812-30-0

Carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides etc, nesoi

Fórmula: C₁₅H₂₂O₃

Forma y color: Off-White White Powder

Peso molecular: 250.15689

Ref: 45-1288500

Gemfibrozil

CAS: 25812-30-0

Gemfibrozil, a fibric acid derivative, stimulates PPARalpha, boosts fatty acid oxidation, LPL, lowers VLDL-C, apoC-III, and raises HDL-C.

Fórmula: C₁₅H₂₂O₃

Pureza: 99.53% - 99.88%

Forma y color: Crystals From Hexane Solid

Peso molecular: 250.3334

Ref: TM-T1415

Gemfibrozil

CAS: 25812-30-0

Gemfibrozil

Fórmula: C₁₅H₂₂O₃

Pureza: >98%

Forma y color: Solid

Peso molecular: 250.33

Ref: 54-OR1029081

Gemfibrozil

CAS: 25812-30-0

Gemfibrozil

Fórmula: C₁₅H₂₂O₃

Pureza: ≥98%

Peso molecular: 250.33

Ref: 54-BUP14848

Gemfibrozil

CAS: 25812-30-0

Fórmula: C₁₅H₂₂O₃

Pureza: ≥ 98.0% (anhydrous basis)

Forma y color: White crystalline powder

Peso molecular: 250.33

Ref: 7W-GP1460

Gemfibrozil

CAS: 25812-30-0

Fórmula: C₁₅H₂₂O₃

Forma y color: White To Off-White Solid

Peso molecular: 250.34

Ref: 4Z-G-1211

Gemfibrozil (Standard)

CAS: 25812-30-0

Gemfibrozil (Standard) is the standard substance of Gemfibrozil, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Gemfibrozil (CI-719) interacts with peroxisome proliferator-activated receptors (PPARalpha) resulting in PPARalpha-mediated stimulation of fatty acid oxidation and an increase in lipoprotein lipase (LPL) synthesis. Gemfibrozil is a fibric acid derivative with hypolipidemic effects. This enhances triglyceride-rich lipoprotein clearance and reduces the expression of apolipoprotein C-III (apoC-III). The reduction in hepatic production of apoC-III result in the subsequent reduction of serum levels of very-low-density-lipoprotein cholesterol (VLDL-C). In addition, gemfibrozil-mediated PPARalpha stimulation of apoA-I and apoA-II expression results in an increase in high-density lipoprotein cholesterol (HDL-C).

Fórmula: C₁₅H₂₂O₃

Peso molecular: 250.3334

Ref: TM-TMSM-1256

Gemfibrozil

CAS: 25812-30-0

Fórmula: C₁₅H₂₂O₃

Forma y color: Neat

Peso molecular: 250.33

Ref: 04-C13999000

Pharmaceuticals Mixture 327 200 µg/mL in Methanol

Producto controlado

CAS: 15687-27-1, 22204-53-1, 25812-30-0, 3380-34-5

Forma y color: Mixture

Ref: 04-A50000327ME

Gemfibrozil

Producto controlado

CAS: 25812-30-0

Fórmula: C₁₅H₂₂O₃

Forma y color: Neat

Peso molecular: 250.33

Ref: 86-MM0641.00

Gemfibrozil 100 µg/mL in Acetonitrile

CAS: 25812-30-0

Fórmula: C₁₅H₂₂O₃

Forma y color: Single Solution

Peso molecular: 250.33

Ref: 04-A13999000AL-100

5-(2,5-Dimethylphenoxy)-2,2-dimethylpentanoic acid

CAS: 25812-30-0

Fórmula: C₁₅H₂₂O₃

Pureza: 98%

Forma y color: Solid

Peso molecular: 250.3334

Ref: IN-DA0034YR

Gemfibrozil

Producto controlado

CAS: 25812-30-0

Applications A serum lipid regulating agent used as an antihyperlipoproteinemic.This compound is a contaminant of emerging concern (CECs).
References Kissebach, A.H., et al.: Atherosclerosis, 24, 199 (1976), Lewis, J.E., et al.: Pract. Cardiol., 9, 99 (1983), Rubins, H.B., et al.: N. Engl. J. Med., 341, 410 (1999)

Fórmula: C₁₅H₂₂O₃

Forma y color: Neat

Peso molecular: 250.33

Ref: TR-G305750

Gemfibrozil

CAS: 25812-30-0

5-(2,5-Dimethylphenoxy)-2,2-dimethylpentanoic acid

Fórmula: C₁₅H₂₂O₃

Pureza: 98%

Peso molecular: 250.33

Ref: IN-DG32912

Gemfibrozil

CAS: 25812-30-0

Fórmula: C₁₅H₂₂O₃

Peso molecular: 250.34

Ref: ST-EA-CP-G25000

Gemfibrozil

CAS: 25812-30-0

Gemfibrozil is a chemical inhibitor that inhibits the response element to the transcription factor PPAR-α. It has been shown to decrease cardiac effects such as increased heart rate, stroke volume, and cardiac output. Gemfibrozil has been used for wastewater treatment and has been found to be an analytical method for determining the concentration of other drugs in urine. The ecological effects of gemfibrozil are not well understood, but it is known that it can cause adverse effects on locomotor activity in animals. Gemfibrozil is a potent inducer of liver enzymes and may interact with other drugs by increasing their concentration time curve. This drug also has oral hypoglycemic properties, which lowers the blood glucose level by stimulating insulin production.

Fórmula: C₁₅H₂₂O₃

Pureza: Min. 95%

Peso molecular: 250.33 g/mol

Ref: 3D-FD23652