CAS 25812-30-0

gemfibrozilo

Descripción:

gemfibrozilo es un medicamento que se utiliza principalmente para reducir los niveles de lípidos en pacientes con hiperlipidemia, particularmente para reducir los triglicéridos y aumentar el colesterol de lipoproteínas de alta densidad (HDL). Pertenece a la clase de medicamentos conocidos como fibratos y actúa activando el receptor alfa activado por proliferadores de peroxisomas (PPARα), lo que mejora la oxidación de ácidos grasos y disminuye la producción de triglicéridos en el hígado. Químicamente, gemfibrozilo se caracteriza por su fórmula molecular, que incluye átomos de carbono, hidrógeno y oxígeno, y tiene una configuración estructural específica que contribuye a su actividad farmacológica. La sustancia se administra típicamente por vía oral y se absorbe bien en el tracto gastrointestinal. Su farmacocinética implica un metabolismo extenso en el hígado, principalmente a través de la glucuronidación, y tiene una vida media relativamente larga, lo que permite una dosificación dos veces al día. Los efectos secundarios comunes pueden incluir trastornos gastrointestinales, y está contraindicado en pacientes con enfermedad hepática o renal severa. Al igual que con cualquier medicamento, es esencial monitorear los niveles de lípidos y las posibles interacciones medicamentosas durante el tratamiento.

Fórmula: C₁₅H₂₂O₃

InChI: InChI=1/C15H22O3/c1-11-6-7-12(2)13(10-11)18-9-5-8-15(3,4)14(16)17/h6-7,10H,5,8-9H2,1-4H3,(H,16,17)

Clave InChI: InChIKey=HEMJJKBWTPKOJG-UHFFFAOYSA-N

SMILES: O(CCCC(C(O)=O)(C)C)C1=C(C)C=CC(C)=C1

Sinónimos:

• 2,2-Dimethyl-5-(2,5-dimethylphenoxy)pentanoic acid
• 2,2-Dimethyl-5-(2,5-dimethylphenoxy)valeriansaeure
• 2,2-Dimethyl-5-(2,5-xylyloxy)valeriansaeure
• 2,2-Dimethyl-5-(2,5-xylyloxy)valeric acid
• 5-(2,5-Dimethylphenoxy)-2,2-dimethylpentanoic acid
• 5-[(2,5-Dimethylphenyl)oxy]-2,2-dimethylpentanoic acid
• Apo-Gemfibrozil
• Ausgem
• Bolutol
• Brn 1881200
• Brozil
• Ccris 318
• Cholespid
• Ci 719
• Clearol
• Decrelip
• Elmogan
• Fetinor
• Fibratol
• Fibrocit
• Gem-S
• Gemd
• Gemfibril
• Gemfibromax
• Gemfibrozil [USAN:INN:BAN]
• Gemfibrozilo
• Gemfibrozilo [INN-Spanish]
• Gemfibrozilum
• Gemfibrozilum [INN-Latin]
• Gemlipid
• Gemnpid
• Genlip
• Gevilon
• Gevilon Uno
• Gozid
• Hidil
• Hipolixan
• Hsdb 7735
• Innogen
• Ipolipid
• Jezil
• Lanaterom
• Lifibron
• Lipazil
• Lipigem
• Lipira
• Lipizyl
• Lipur
• Litarek
• Lopid
• Lopizid
• Low-Lip
• Micolip
• Normolip
• Pentanoic acid, 5-(2,5-dimethylphenoxy)-2,2-dimethyl-
• Pilder
• Polyxit
• Progemzal
• Reducel
• Regulip
• Renabrazin
• Sinelip
• Synbrozil
• Taborcil
• Tentroc
• Trialmin
• Trialmin 900
• Unii-Q8X02027X3
• Valeric acid, 2,2-dimethyl-5-(2,5-xylyloxy)-
• WL-Gemfibrozil
• Gemfibrozil
• 5-(2,5-DIMETHYLPHENOXY)-2,2-DIMETHYLPENTANOICACID(GEMFIBROZIL)
• GEMFIBROZIL,USP
• 2,2-DIMETHYL-5-[2,5-DIMETHYL-PHENOXY]PENTANOIC ACID
• 5-(2,5-dimethylphenoxy)-2,2-dimethyl-pentanoicaci
• 5-(2,5-DIMETHYLPHYLPHENOXY)-2,2-DIMETHYLPENTANOIC ACID
• Lipozid
• 2,2-dimethyl-5-(2,5-xylyloxy)-valericaci
• 5-(2,5-Dimethylphenoxy)-2,2-dimethylpentanoic Acid, CI-719, Decrelip, Genlip, Gevilon, Lipozid, Lpur, Lopid
• Gemcitabine intermediates
• 5-(2,5-Dimethylphenoxy)-2,2-DimethylpentamoicAcid
• 2,2-Dimethyl-5-(2,5-Dimethylphenoxy)Valeric
• CI-7

Gemfibrozil

CAS: 25812-30-0

Fórmula: C₁₅H₂₂O₃

Pureza: >98.0%(GC)(T)

Forma y color: White to Almost white powder to crystal

Peso molecular: 250.34

Ref: 3B-G0368

GEMFIBROZIL FOR SYSTEM SUITABILITY CRS

CAS: 25812-30-0

GEMFIBROZIL FOR SYSTEM SUITABILITY CRS

Fórmula: C₁₅H₂₂O₃

Peso molecular: 250.3334

Ref: 41-Y0000514

GEMFIBROZIL CRS

CAS: 25812-30-0

GEMFIBROZIL CRS

Fórmula: C₁₅H₂₂O₃

Forma y color: Added Modified

Peso molecular: 250.3334

Ref: 41-Y0000513

Gemfibrozil

CAS: 25812-30-0

Gemfibrozil

Fórmula: C₁₅H₂₂O₃

Pureza: 99.9%

Forma y color: White Solid

Peso molecular: 250.15689

Ref: 47-363

Gemfibrozil

CAS: 25812-30-0

Carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides etc, nesoi

Fórmula: C₁₅H₂₂O₃

Forma y color: Off-White White Powder

Peso molecular: 250.15689

Ref: 45-1288500

Gemfibrozil

CAS: 25812-30-0

Gemfibrozil, a fibric acid derivative, stimulates PPARalpha, boosts fatty acid oxidation, LPL, lowers VLDL-C, apoC-III, and raises HDL-C.

Fórmula: C₁₅H₂₂O₃

Pureza: 99.53% - 99.88%

Forma y color: Crystals From Hexane Solid

Peso molecular: 250.3334

Ref: TM-T1415

Gemfibrozil

CAS: 25812-30-0

Gemfibrozil

Fórmula: C₁₅H₂₂O₃

Pureza: >98%

Forma y color: Solid

Peso molecular: 250.33

Ref: 54-OR1029081

Gemfibrozil

CAS: 25812-30-0

Gemfibrozil

Fórmula: C₁₅H₂₂O₃

Pureza: ≥98%

Peso molecular: 250.33

Ref: 54-BUP14848

Gemfibrozil

CAS: 25812-30-0

Fórmula: C₁₅H₂₂O₃

Pureza: ≥ 98.0% (anhydrous basis)

Forma y color: White crystalline powder

Peso molecular: 250.33

Ref: 7W-GP1460

Gemfibrozil

CAS: 25812-30-0

Fórmula: C₁₅H₂₂O₃

Forma y color: White To Off-White Solid

Peso molecular: 250.34

Ref: 4Z-G-1211

Gemfibrozil (Standard)

CAS: 25812-30-0

Gemfibrozil (Standard) is the standard substance of Gemfibrozil, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Gemfibrozil (CI-719) interacts with peroxisome proliferator-activated receptors (PPARalpha) resulting in PPARalpha-mediated stimulation of fatty acid oxidation and an increase in lipoprotein lipase (LPL) synthesis. Gemfibrozil is a fibric acid derivative with hypolipidemic effects. This enhances triglyceride-rich lipoprotein clearance and reduces the expression of apolipoprotein C-III (apoC-III). The reduction in hepatic production of apoC-III result in the subsequent reduction of serum levels of very-low-density-lipoprotein cholesterol (VLDL-C). In addition, gemfibrozil-mediated PPARalpha stimulation of apoA-I and apoA-II expression results in an increase in high-density lipoprotein cholesterol (HDL-C).

Fórmula: C₁₅H₂₂O₃

Peso molecular: 250.3334

Ref: TM-TMSM-1256

Gemfibrozil

CAS: 25812-30-0

Fórmula: C₁₅H₂₂O₃

Forma y color: Neat

Peso molecular: 250.33

Ref: 04-C13999000

Pharmaceuticals Mixture 327 200 µg/mL in Methanol

Producto controlado

CAS: 15687-27-1, 22204-53-1, 25812-30-0, 3380-34-5

Forma y color: Mixture

Ref: 04-A50000327ME

Gemfibrozil

Producto controlado

CAS: 25812-30-0

Fórmula: C₁₅H₂₂O₃

Forma y color: Neat

Peso molecular: 250.33

Ref: 86-MM0641.00

Gemfibrozil 100 µg/mL in Acetonitrile

CAS: 25812-30-0

Fórmula: C₁₅H₂₂O₃

Forma y color: Single Solution

Peso molecular: 250.33

Ref: 04-A13999000AL-100

5-(2,5-Dimethylphenoxy)-2,2-dimethylpentanoic acid

CAS: 25812-30-0

Fórmula: C₁₅H₂₂O₃

Pureza: 98%

Forma y color: Solid

Peso molecular: 250.3334

Ref: IN-DA0034YR

Gemfibrozil

Producto controlado

CAS: 25812-30-0

Applications A serum lipid regulating agent used as an antihyperlipoproteinemic.This compound is a contaminant of emerging concern (CECs).
References Kissebach, A.H., et al.: Atherosclerosis, 24, 199 (1976), Lewis, J.E., et al.: Pract. Cardiol., 9, 99 (1983), Rubins, H.B., et al.: N. Engl. J. Med., 341, 410 (1999)

Fórmula: C₁₅H₂₂O₃

Forma y color: Neat

Peso molecular: 250.33

Ref: TR-G305750

Gemfibrozil

CAS: 25812-30-0

5-(2,5-Dimethylphenoxy)-2,2-dimethylpentanoic acid

Fórmula: C₁₅H₂₂O₃

Pureza: 98%

Peso molecular: 250.33

Ref: IN-DG32912

Gemfibrozil

CAS: 25812-30-0

Fórmula: C₁₅H₂₂O₃

Peso molecular: 250.34

Ref: ST-EA-CP-G25000

Gemfibrozil

CAS: 25812-30-0

Fórmula: C₁₅H₂₂O₃

Forma y color: Solid

Peso molecular: 250.33

Ref: BE-RMCG040000