CAS 2588489-03-4

Fórmula: C22H34O4

InChI: InChI=1S/C22H34O4/c1-21(2,19(23)24)15-7-5-9-17-11-13-18(14-12-17)10-6-8-16-22(3,4)20(25)26/h11-14H,5-10,15-16H2,1-4H3,(H,23,24)(H,25,26)

Clave InChI: HMPYTWJWXBNCLQ-UHFFFAOYSA-N

SMILES: CC(C)(CCCCC1=CC=C(C=C1)CCCCC(C)(C)C(=O)O)C(=O)O

EVT0185

CAS: 2588489-03-4

EVT0185 is an orally active ATP citrate lyase (ACLY) inhibitor. In the liver, it is converted by SLC27A2 into a CoA thioester, which interacts with the CoA binding site of ACLY. EVT0185-CoA inhibits ACLY activity with an IC50 of 2.5 μM. It mimics the immune and antitumor effects seen with ACLY gene deletion. Additionally, EVT0185 elevates levels of tumor-infiltrating B cells and the chemokine CXCL13. It is applicable in cancer research, including hepatocellular carcinoma (HCC).

Fórmula: C₂₂H₃₄O₄

Forma y color: Solid

Peso molecular: 362.50

Ref: TM-T212436