CAS 2635386-55-7

Fórmula: C47H51ClF2N12O10

InChI: InChI=1S/C47H51ClF2N12O10/c48-47(49,50)72-33-9-7-30(8-10-33)55-43(65)29-25-35(36-13-15-53-58-36)42(52-26-29)60-17-14-31(27-60)54-39(63)6-1-3-32-28-61(59-57-32)18-20-70-22-24-71-23-21-69-19-16-51-37-5-2-4-34-41(37)46(68)62(45(34)67)38-11-12-40(64)56-44(38)66/h2,4-5,7-10,13,15,25-26,28,31,38,51H,1,3,6,11-12,14,16-24,27H2,(H,53,58)(H,54,63)(H,55,65)(H,56,64,66)/t31-,38?/m1/s1

Clave InChI: LUCAXHCIOIVJQP-LERZKORDSA-N

SMILES: C1CN(C[C@@H]1NC(=O)CCCC2=CN(N=N2)CCOCCOCCOCCNC3=CC=CC4=C3C(=O)N(C4=O)C5CCC(=O)NC5=O)C6=C(C=C(C=N6)C(=O)NC7=CC=C(C=C7)OC(F)(F)Cl)C8=CC=NN8

P19As

CAS: 2635386-55-7

P19As is a BCR-ABL PROTAC degrader based on Asciminib, with a DC50 of approximately 200 nM for the wild-type BCR-ABL protein. It is capable of degrading the T315I mutant and demonstrates strong antiproliferative activity in BaF3-BCR-ABL (T315I) cells. P19As is applicable for research in chronic myeloid leukemia and acute lymphoblastic leukemia.

Fórmula: C₄₇H₅₁ClF₂N₁₂O₁₀

Peso molecular: 1017.45

Ref: TM-T217196