CAS 2651196-69-7

Fórmula: C20H20F2N8O

InChI: InChI=1S/C20H20F2N8O/c21-13-3-4-14-17(16(13)22)26-15(25-14)10-23-19-28-20(29-5-7-31-8-6-29)27-18-12(11-1-2-11)9-24-30(18)19/h3-4,9,11H,1-2,5-8,10H2,(H,25,26)(H,23,27,28)

Clave InChI: UXJVUCJEHIXDPU-UHFFFAOYSA-N

SMILES: C1CC1C2=C3N=C(N=C(N3N=C2)NCC4=NC5=C(N4)C=CC(=C5F)F)N6CCOCC6

CDK12-IN-4

CAS: 2651196-69-7

CDK12-IN-4 is a pyrazolotriazine that inhibits CDK12 (IC50: 0.641 μM) with high ATP (2 mM) and spares CDK2/Cyclin E and CDK9/Cyclin T1 (IC50: >20 μM).

Fórmula: C₂₀H₂₀F₂N₈O

Forma y color: Solid

Peso molecular: 426.432

Ref: TM-T40288