CAS 27740-01-8

Escutelarina

Descripción:

Escutelarina es un glucósido flavonoide derivado principalmente de la planta Scutellaria baicalensis, comúnmente conocida como escutelaria de Baikal. Se caracteriza por su estructura química, que incluye un esqueleto de flavona unido a un moiety de glucosa. Escutelarina exhibe diversas actividades biológicas, incluyendo efectos antioxidantes, antiinflamatorios y neuroprotectores, lo que lo hace de interés en la investigación farmacológica. El compuesto es soluble en agua y presenta una estabilidad moderada en condiciones estándar. Sus posibles aplicaciones terapéuticas se están explorando en áreas como enfermedades neurodegenerativas y salud cardiovascular. Además, se ha estudiado Escutelarina por su capacidad para modular diversas vías de señalización, contribuyendo a sus diversos efectos farmacológicos. Al igual que muchos compuestos naturales, la eficacia y seguridad de Escutelarina están sujetas a investigaciones en curso, particularmente en lo que respecta a su biodisponibilidad y mecanismos de acción en sistemas biológicos.

Fórmula: C₂₁H₁₈O₁₂

InChI: InChI=1S/C21H18O12/c22-8-3-1-7(2-4-8)10-5-9(23)13-11(31-10)6-12(14(24)15(13)25)32-21-18(28)16(26)17(27)19(33-21)20(29)30/h1-6,16-19,21-22,24-28H,(H,29,30)/t16-,17-,18+,19-,21+/m0/s1

Clave InChI: InChIKey=DJSISFGPUUYILV-ZFORQUDYSA-N

SMILES: O=C1C=2C(OC(=C1)C3=CC=C(O)C=C3)=CC(O[C@@H]4O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]4O)=C(O)C2O

Sinónimos:

• 5,6-Dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-7-yl β-<span class="text-smallcaps">D</span>-glucopyranosiduronic acid
• 7-(beta-D-Glucopyranuronosyloxy)-5,6-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
• Flavone, 4′,5,6,7-tetrahydroxy-, 7-β-<span class="text-smallcaps">D</span>-glucopyranuronoside
• Glucopyranosiduronic acid, 5,6-dihydroxy-2-(p-hydroxyphenyl)-4-oxo-4H-1-benzopyran-7-yl, β-<span class="text-smallcaps">D</span>-
• Scutellarein 7-O-β-<span class="text-smallcaps">D</span>-glucuronide
• Scutellarein 7-O-β-glucuronide
• Scutellarein 7-glucuronide
• Scutellarein 7-β-<span class="text-smallcaps">D</span>-glucuronide
• Scutellarein 7-β-<span class="text-smallcaps">D</span>-glucuronoside
• Scutellarin B
• β-<span class="text-smallcaps">D</span>-Glucopyranosiduronic acid, 5,6-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-7-yl
• Glucopyranosiduronic acid, 5,6-dihydroxy-2-(p-hydroxyphenyl)-4-oxo-4H-1-benzopyran-7-yl, β-D-
• Flavone, 4′,5,6,7-tetrahydroxy-, 7-β-D-glucopyranuronoside
• β-D-Glucopyranosiduronic acid, 5,6-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-7-yl
• Scutellarin

Scutellarin

CAS: 27740-01-8

Scutellarin analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Fórmula: C₂₁H₁₈O₁₂

Pureza: (HPLC) ≥98%

Forma y color: Powder

Peso molecular: 462.37

Ref: 11-1405S

β-D-Glucopyranosiduronic acid, 5,6-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-7-yl

CAS: 27740-01-8

Fórmula: C₂₁H₁₈O₁₂

Pureza: 97%

Forma y color: Solid

Peso molecular: 462.3604

Ref: IN-DA002UML

Scutellarin

CAS: 27740-01-8

Fórmula: C₂₁H₁₈O₁₂

Pureza: (HPLC) ≥ 98.0%

Forma y color: Yellow to brown powder

Peso molecular: 462.36

Ref: 7W-GC9987

(2S,3S,4S,5R,6S)-6-((5,6-Dihydroxy-2-(4-Hydroxyphenyl)-4-Oxo-4H-Chromen-7-Yl)Oxy)-3,4,5-Trihydroxytetrahydro-2H-Pyran-2-Carboxylic Acid

CAS: 27740-01-8

(2S,3S,4S,5R,6S)-6-((5,6-Dihydroxy-2-(4-Hydroxyphenyl)-4-Oxo-4H-Chromen-7-Yl)Oxy)-3,4,5-Trihydroxytetrahydro-2H-Pyran-2-Carboxylic Acid

Pureza: 98%

Peso molecular: 462.36g/mol

Ref: 54-OR1008029

Scutellarin

CAS: 27740-01-8

Scutellarin

Pureza: ≥95%

Peso molecular: 462.36g/mol

Ref: 54-BUP11189

Scutellarin

CAS: 27740-01-8

Scutellarin has many pharmacological effects, such as antioxidant, antitumor, antiviral, neuroprotection and antiinflammatory activities. It down-regulates the STAT3/Girdin/Akt signaling in HCC cells, and inhibits RANKL-mediated MAPK and NF-κB signaling pathway in osteoclasts.

Fórmula: C₂₁H₁₈O₁₂

Pureza: 95%~99%

Peso molecular: 462.363

Ref: BP-BP1278

Scutellarin

CAS: 27740-01-8

Scutellarin from Scutellaria inhibits RANKL in osteoclasts and STAT3/Girdin/Akt in HCC cells.

Fórmula: C₂₁H₁₈O₁₂

Pureza: 97.12% - 99.75%

Forma y color: Solid

Peso molecular: 462.36

Ref: TM-T2789

Scutellarin

CAS: 27740-01-8

Natural glycoside

Fórmula: C₂₁H₁₈O₁₂

Pureza: ≥ 95.0 % (HPLC)

Forma y color: Powder

Peso molecular: 462.37

Ref: 5G-89788

Scutellarin

CAS: 27740-01-8

Applications Scutellarin is an active flavonoid component from the medical plant Erigeron breviscapus (Vant) Hand-Mazz. Scutellarin is used as a micrpcirculation promoter for the treatment of cardio-cerebrovascular diseases. Studies suggest that Scutellarin has anti-cancer properties and has been shown to enhance apoptosis of tumor cells.
References Gao, C. et al.: Drug Metab. Dispos., 39, 2034 (2011); Chan, J.Y. et al.: Anticancer Res., 29, 3043 (2009); Wang, C.-Z. et al.: Phytomedicine, 17, 63 (2010);

Fórmula: C₂₁H₁₈O₁₂

Forma y color: Neat

Peso molecular: 462.36

Ref: TR-S201900

Scutellarin

CAS: 27740-01-8

Scutellarin is a bioactive flavonoid compound, which is derived primarily from the plant Scutellaria baicalensis and other species within the Scutellaria genus. As a naturally occurring phytochemical, Scutellarin exerts its effects through multiple biological pathways, including antioxidant, anti-inflammatory, and anti-apoptotic activities.

Fórmula: C₂₁H₁₈O₁₂

Pureza: Min. 95%

Forma y color: Yellow Powder

Peso molecular: 462.36 g/mol

Ref: 3D-MS08111