CAS 2809982-26-9

EGFR-IN-133

CAS: 2809982-26-9

EGFR-IN-133 (Compound 24) serves as an inhibitor targeting various mutations of the EGFR, including the wild type, L858R/T790M, d19/T790M, L858R/T790M/C797S, and d19/T790M/C797S with respective IC₅₀ values of 0.1, 0.044, 0.036, 0.04, and 0.054 nM. The compound exhibits favorable pharmacokinetic properties and high oral bioavailability.

Fórmula: C₂₇H₂₉F₂N₇O₃

Forma y color: Solid

Peso molecular: 537.56

Ref: TM-T201790