CAS 2919963-24-7

Fórmula: C54H67F3N10O6S

InChI: InChI=1S/C54H67F3N10O6S/c1-33(35-10-12-37(13-11-35)48-34(2)61-32-74-48)62-50(70)45-28-39(68)30-67(45)52(72)49(53(3,4)5)63-46(69)9-7-6-8-20-64-23-25-65(26-24-64)38-14-16-42-44(27-38)59-31-60-47(42)36-18-21-66(22-19-36)51(71)41-17-15-40(29-43(41)58)73-54(55,56)57/h10-17,27,29,31-33,36,39,45,49,68H,6-9,18-26,28,30,58H2,1-5H3,(H,62,70)(H,63,69)/t33-,39+,45-,49+/m0/s1

Clave InChI: BOXPLNRWIHHHBO-CHCOZFFLSA-N

SMILES: CC1=C(SC=N1)C2=CC=C(C=C2)[C@H](C)NC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)CCCCCN4CCN(CC4)C5=CC6=C(C=C5)C(=NC=N6)C7CCN(CC7)C(=O)C8=C(C=C(C=C8)OC(F)(F)F)N)O

PROTAC ERK5 degrader-1

CAS: 2919963-24-7

PROTACERK5 degrader-1 (compound 2) is a bifunctional ERK5 PROTAC degrader. It induces the degradation of ERK5 in MOLT-4 cells via a VHL-mediated proteasome pathway. PROTACERK5 degrader-1 is useful for studying diseases or disorders characterized by abnormal ERK5 activity.

Fórmula: C₅₄H₆₇F₃N₁₀O₆S

Forma y color: Solid

Peso molecular: 1041.23

Ref: TM-T210807