CAS 2920000-23-1

Fórmula: C27H29F3N2O5

InChI: InChI=1S/C27H29F3N2O5/c1-17(2)25-22(24(31-37-25)21-5-3-4-6-23(21)36-27(28,29)30)15-32-13-11-18(12-14-32)16-35-20-9-7-19(8-10-20)26(33)34/h3-10,17-18H,11-16H2,1-2H3,(H,33,34)

Clave InChI: LLXJYUIZLAWRAS-UHFFFAOYSA-N

SMILES: CC(C)C1=C(C(=NO1)C2=CC=CC=C2OC(F)(F)F)CN3CCC(CC3)COC4=CC=C(C=C4)C(=O)O

LZ-007

CAS: 2920000-23-1

LZ-007 is an agonist of the Farnesoid X receptor (FXR), with an EC50 of 51 nM as determined by TR-FRET assay, and an EC50 of 76 nM in HepG2 cells. It exhibits favorable pharmacokinetic properties in SD rats and can improve metabolic dysfunction-associated steatohepatitis induced by high-fat diets and CCl4 in mice.

Fórmula: C₂₇H₂₉F₃N₂O₅

Forma y color: Solid

Peso molecular: 518.53

Ref: TM-T203062