CAS 2930131-74-9

HD202A

CAS: 2930131-74-9

HD202A is an orally active, selective dual inhibitor of MNK1/MNK2 (with IC₅₀ values of 6.09 nM and 8.06 nM, respectively; Kd values of 1.913 μM and 5.244 μM, respectively), and it inhibits the MNK-eIF4E signaling pathway. By downregulating perilipin 2 and SCD1 while upregulating adipose triglyceride lipase and PPARγ coactivator 1α, HD202A enhances mitochondrial fatty acid oxidation and redox homeostasis. This compound effectively curtails weight gain, hepatic lipid accumulation, and elevated serum lipid levels, while significantly improving glucose tolerance and insulin sensitivity, and reducing inflammatory characteristics. HD202A shows significant potential for research applications in metabolic dysfunction-associated fatty liver disease.

Fórmula: C₂₅H₂₄N₆OS

Peso molecular: 456.56

Ref: TM-T218370