CAS 2940242-88-4

Fórmula: C38H39N11O6

InChI: InChI=1S/C38H39N11O6/c39-32-30-31(21-5-9-28-26(15-21)44-38(40)55-28)46-49(33(30)43-18-42-32)23-11-13-47(14-12-23)35(52)20-3-1-19(2-4-20)17-41-22-6-7-24-25(16-22)37(54)48(36(24)53)27-8-10-29(50)45-34(27)51/h5-7,9,15-16,18-20,23,27,41H,1-4,8,10-14,17H2,(H2,40,44)(H2,39,42,43)(H,45,50,51)

Clave InChI: SJGHLAIIEHJIND-UHFFFAOYSA-N

SMILES: C1CC(CCC1CNC2=CC3=C(C=C2)C(=O)N(C3=O)C4CCC(=O)NC4=O)C(=O)N5CCC(CC5)N6C7=NC=NC(=C7C(=N6)C8=CC9=C(C=C8)OC(=N9)N)N

YB-3-17

CAS: 2940242-88-4

YB-3-17 is a bifunctional molecule that can inhibit mTOR with an IC₅₀ of 0.22 nM or degrade the G1 to S phase transition 1 gene (GSPT1) through the PROTAC mechanism, with a DC50 of 5 nM. It exhibits antiproliferative activity at nanomolar concentrations in various glioblastoma cell lines. Additionally, YB-3-17 shows antitumor activity in mouse models. (Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligase Cereblon)

Fórmula: C₃₈H₃₉N₁₁O₆

Forma y color: Solid

Peso molecular: 745.786

Ref: TM-T204111