CAS 2982696-04-6

Fórmula: C19H15F3N2O3S2

InChI: InChI=1S/C19H15F3N2O3S2/c1-11-8-14(6-7-15(11)27-9-17(25)26)28-10-16-23-24-18(29-16)12-2-4-13(5-3-12)19(20,21)22/h2-8H,9-10H2,1H3,(H,25,26)

Clave InChI: NLJZRFBMZSIDNW-UHFFFAOYSA-N

SMILES: CC1=C(C=CC(=C1)SCC2=NN=C(S2)C3=CC=C(C=C3)C(F)(F)F)OCC(=O)O

2-(2-Methyl-4-(((5-(4-(trifluoromethyl)phenyl)-1,3,4-thiadiazol-2-yl)methyl)thio)phenoxy)acetic acid

CAS: 2982696-04-6

2-(2-Methyl-4-(((5-(4-(trifluoromethyl)phenyl)-1,3,4-thiadiazol-2-yl)methyl)thio)phenoxy)acetic acid

Fórmula: C₁₉H₁₅F₃N₂O₃S₂

Pureza: 95%

Peso molecular: 440.47

Ref: 54-PC1008017

2-(2-Methyl-4-(((5-(4-(trifluoromethyl)phenyl)-1,3,4-thiadiazol-2-yl)methyl)thio)phenoxy)acetic acid

CAS: 2982696-04-6

2-(2-Methyl-4-(((5-(4-(trifluoromethyl)phenyl)-1,3,4-thiadiazol-2-yl)methyl)thio)phenoxy)acetic acid

Fórmula: C₁₉H₁₅F₃N₂O₃S₂

Pureza: 95%

Peso molecular: 440.46

Ref: IN-DG02758880

PPARδ agonist 11

CAS: 2982696-04-6

Compound 11, a selective PPARδ agonist, demonstrates an EC50 of 20 nM, indicating its high affinity for PPARδ receptors. This compound efficiently reduces levels of nitric oxide (NO), as well as the pro-inflammatory cytokines TNFα and IL-6 in LPS-stimulated RAW264.7 cells via the NF-κB pathway, showcasing its anti-inflammatory properties. Additionally, Compound 11 exhibits remarkable stability in human liver microsomes and plasma. It significantly ameliorates foot edema induced by Carrageenan, displaying favorable pharmacokinetic properties with a bioavailability of approximately 100%.

Fórmula: C₁₉H₁₅F₃N₂O₃S₂

Forma y color: Solid

Peso molecular: 440.46

Ref: TM-T200543