CAS 3053222-76-4

Fórmula: C32H23ClF3N7O4

InChI: InChI=1S/C32H23ClF3N7O4/c1-47-28-17-41(30(44)15-24(28)23-14-21(33)9-12-26(23)43-18-29(38-40-43)32(34,35)36)27(13-19-5-3-2-4-6-19)25-16-42(39-37-25)22-10-7-20(8-11-22)31(45)46/h2-12,14-18,27H,13H2,1H3,(H,45,46)/t27-/m0/s1

Clave InChI: BHLRKIWHCPZELB-MHZLTWQESA-N

SMILES: COC1=CN(C(=O)C=C1C2=C(C=CC(=C2)Cl)N3C=C(N=N3)C(F)(F)F)[C@@H](CC4=CC=CC=C4)C5=CN(N=N5)C6=CC=C(C=C6)C(=O)O

FXIa-IN-15

CAS: 3053222-76-4

FXIa-IN-15 (Compound (S)-10h) is an inhibitor of factor XIa (FXIa) and plasma kallikrein (PKa) with IC50 values of 0.38 nM and 59.2 nM, respectively. It exhibits anticoagulant properties by prolonging the 50% activated partial thromboplastin time (aPTT) with an EC1.5X of 0.55 μM.

Fórmula: C₃₂H₂₃ClF₃N₇O₄

Forma y color: Solid

Peso molecular: 662.02

Ref: TM-T203612