CAS 3058330-82-5

Fórmula: C30H39N9O6

InChI: InChI=1S/C30H39N9O6/c40-23-9-8-22(25(41)33-23)39-26(42)20-6-5-7-21(24(20)27(39)43)31-10-3-1-2-4-11-32-28-34-29(37-12-16-44-17-13-37)36-30(35-28)38-14-18-45-19-15-38/h5-7,22,31H,1-4,8-19H2,(H,33,40,41)(H,32,34,35,36)

Clave InChI: WOEWVQLKYTZNJD-UHFFFAOYSA-N

SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NCCCCCCNC4=NC(=NC(=N4)N5CCOCC5)N6CCOCC6

PD-M6

CAS: 3058330-82-5

PD-M6 is an mTOR PROTAC degrader with a DC50 of 4.8 μM, which facilitates the ubiquitination and degradation of mTOR. It inhibits the proliferation of cancer cell lines HeLa, MCF-7, and HepG2 with IC₅₀ values of 11.3, 2.58, and 3.23 μM, respectively, and induces autophagy. Additionally, PD-M6 specifically targets the degradation of the key protein LAMTOR1 in the mTOR signaling pathway.

Fórmula: C₃₀H₃₉N₉O₆

Forma y color: Solid

Peso molecular: 621.69

Ref: TM-T207406