CAS 3065634-19-4
:Fórmula:C28H25N7O2
InChI:InChI=1S/C28H25N7O2/c1-16(18-6-4-3-5-7-18)29-27(37)25-22-14-20(10-11-23(22)30-17(2)31-25)21-12-13-35-24(15-21)32-28(34-35)33-26(36)19-8-9-19/h3-7,10-16,19H,8-9H2,1-2H3,(H,29,37)(H,33,34,36)/t16-/m0/s1
Clave InChI:NADGIMFCUNTYJK-INIZCTEOSA-N
SMILES:CC1=NC2=C(C=C(C=C2)C3=CC4=NC(=NN4C=C3)NC(=O)C5CC5)C(=N1)C(=O)N[C@@H](C)C6=CC=CC=C6
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RIPK1-IN-34
CAS:RIPK1-IN-34 is a selective RIPK1 inhibitor capable of penetrating the blood-brain barrier with an IC50 of 126.70 nM, showing minimal inhibition of RIPK3 (IC50 > 10,000 nM). It exerts significant neuroprotective effects by inhibiting the phosphorylation of RIPK1, RIPK3, and mixed lineage kinase domain-like pseudokinase (MLKL) in the necroptosis pathway. RIPK1-IN-34 demonstrates neuroprotective effects in rat models of middle cerebral artery occlusion (MCAO) and is a candidate for research in the treatment of acute ischemic stroke (AIS).Fórmula:C28H25N7O2Peso molecular:491.56
