
CAS 3077918-44-3
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BION106
CAS:BION106 is a PROTAC degrader targeting dihydrofolate reductase-thymidylate synthase (DHFR-TS). It exhibits potent antimalarial activity with a Ki value of 2.68 nM against Plasmodium falciparum and a toxicity of 0.2 μM. For mammalian cells, its Ki value exceeds 100 μM and the toxicity is 44.2 μM. BION106 is suitable for antimalarial research.Fórmula:C57H69Cl2F2N9O9Peso molecular:1133.13

