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CAS 3081876-96-9

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    FXR DUBTAC IN-1

    CAS:
    FXRDUBTAC IN-1 (compound D11) is a deubiquitinase-targeting chimera (DUBTAC) designed to target FXR, with a Ka value of 2.12e-5 M. This compound recruits the deubiquitinase OTUB1 to form a ternary complex with FXR, reducing FXR's polyubiquitination levels. It prevents FXR degradation via the ubiquitin-proteasome pathway, thereby increasing FXR protein levels. FXRDUBTAC IN-1 is used in the study of cholestatic liver injury.
    Fórmula:C43H66N4O7
    Peso molecular:751.01

    Ref: TM-T218558

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