CAS 3086603-12-2
:Fórmula:C23H18FN9O
InChI:InChI=1S/C23H18FN9O/c24-16-3-1-14(2-4-16)10-25-13-22-29-23(32-34-22)19-12-26-21-8-7-20(31-33(19)21)28-17-5-6-18-15(9-17)11-27-30-18/h1-9,11-12,25H,10,13H2,(H,27,30)(H,28,31)
Clave InChI:DAUBJYOCTWSCTB-UHFFFAOYSA-N
SMILES:C1=CC(=CC=C1CNCC2=NC(=NO2)C3=CN=C4N3N=C(C=C4)NC5=CC6=C(C=C5)NN=C6)F
Filtrar por
El filtro de pureza no está visible porque los productos actuales no tienen datos de pureza asociados para filtrar.
Se han encontrado 1 productos.
- Precio más bajo
- Precio más alto
- Pureza más baja
- Pureza más alta
- Entrega estimada más rápida
ROCK2-IN-12
CAS:ROCK2-IN-12 (Compound A25) is a selective inhibitor of ROCK2, exhibiting an IC50 of 7.0 nM for ROCK2, demonstrating greater efficacy compared to ROCK1 inhibition. It exerts potent anti-fibrotic effects via the TGF-β/Smad and ROCK2/STAT3 signaling pathways. In a Bleomycin-induced mouse pulmonary fibrosis (PF) model, ROCK2-IN-12 significantly reduces collagen deposition and reverses fibrosis progression. This compound is applicable in research on pulmonary diseases such as lung fibrosis.Fórmula:C23H18FN9OPeso molecular:455.46
