CAS 3098314-20-3

Fórmula: C33H39N5O7S

InChI: InChI=1S/C26H31N5O4.C7H8O3S/c1-15-10-16(2)24(17(3)11-15)29-23-14-20-19-13-22(35-5)21(34-4)12-18(19)6-8-30(20)26(33)31(23)9-7-28-25(27)32;1-6-2-4-7(5-3-6)11(8,9)10/h10-14H,6-9H2,1-5H3,(H3,27,28,32);2-5H,1H3,(H,8,9,10)

Clave InChI: IDSMKYWDKJXTBL-UHFFFAOYSA-N

SMILES: CC1=CC=C(C=C1)S(=O)(=O)O.CC1=CC(=C(C(=C1)C)N=C2C=C3C4=CC(=C(C=C4CCN3C(=O)N2CCNC(=O)N)OC)OC)C

Ensifentrine tosylate

CAS: 3098314-20-3

Ensifentrine (RPL-554) tosylate is an inhaled dual inhibitor of PDE3 and PDE4, with IC50 values of 0.4 nM and 1479 nM, respectively. By blocking these enzymes, it increases the levels of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) in lung cells, leading to bronchodilation and inhibition of inflammatory cell activation and migration. Ensifentrine tosylate is used in the study of chronic obstructive pulmonary disease (COPD).

Fórmula: C₃₃H₃₉N₅O₇S

Peso molecular: 649.76

Ref: TM-T214818