CAS 3099026-16-8
:Fórmula:C30H35Cl2N5O4S
InChI:InChI=1S/C30H35Cl2N5O4S/c1-21(2)34-11-13-35(14-12-34)27-10-8-24(29(38)36-15-17-37(18-16-36)30(39)28(31)32)20-26(27)33-42(40,41)25-9-7-22-5-3-4-6-23(22)19-25/h3-10,19-21,28,33H,11-18H2,1-2H3
Clave InChI:ZEWRJLAZMVJNGM-UHFFFAOYSA-N
SMILES:CC(C)N1CCN(CC1)C2=C(C=C(C=C2)C(=O)N3CCN(CC3)C(=O)C(Cl)Cl)NS(=O)(=O)C4=CC5=CC=CC=C5C=C4
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PLAGL2-IN-1
CAS:PLAGL2-IN-1 is an inhibitor of pleomorphic adenoma gene-like 2 (PLAGL2) with a dissociation constant (Kd) of 2.23 µM. This compound suppresses the transcriptional activity of PLAGL2, induces G0/G1 cell cycle arrest and apoptosis, thereby inhibiting the proliferation of hepatocellular carcinoma (HCC) cells. It disrupts extracellular matrix structure and inhibits the PI3K-AKT signaling pathway by reducing AKT phosphorylation levels. Additionally, PLAGL2-IN-1 inhibits tumor growth in HCCLM3 xenograft mouse models and is applicable for research in hepatocellular carcinoma.Fórmula:C30H35Cl2N5O4SPeso molecular:632.6
