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CAS 3104736-80-0

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    LUF7996

    CAS:
    LUF7996 is a CCR2-targeting PROTAC degrader with a DC50 of 2.6 μM, designed to degrade CCR2 effectively. It binds simultaneously to CCR2 and the E3 ligase cereblon, demonstrating sustained and concentration-dependent degradation of CCR2. The compound induces CCR2 degradation via the lysosomal pathway and effectively inhibits monocyte migration in vitro.
    Fórmula:C39H34Cl2F3N5O8S
    Peso molecular:860.68

    Ref: TM-T215953

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