CAS 3107483-12-2

Fórmula: C28H28F3N3O4

InChI: InChI=1S/C28H28F3N3O4/c1-36-25-13-19-9-10-34-16-20-11-21(6-5-18(20)12-24(34)23(19)14-26(25)37-2)33-27(35)32-15-17-3-7-22(8-4-17)38-28(29,30)31/h3-8,11,13-14,24H,9-10,12,15-16H2,1-2H3,(H2,32,33,35)/t24-/m1/s1

Clave InChI: QLVMEJODLSQJTN-XMMPIXPASA-N

SMILES: COC1=C(C=C2[C@H]3CC4=C(CN3CCC2=C1)C=C(C=C4)NC(=O)NCC5=CC=C(C=C5)OC(F)(F)F)OC

sEH inhibitor-19

CAS: 3107483-12-2

sEH inhibitor-19 (Compound (R)-14i) is an orally active soluble epoxide hydrolase (sEH) inhibitor with an IC50 of 1.2 nM. This compound suppresses the expression of TNF-α and IL-6 and exhibits anti-inflammatory effects in mouse models of acute pancreatitis and Carrageenan-induced edema.

Fórmula: C₂₈H₂₈F₃N₃O₄

Forma y color: Solid

Peso molecular: 527.535

Ref: TM-T204461