CAS 3107769-23-0

FXR agonist 17

CAS: 3107769-23-0

FXR agonist17 is an orally active, steroidal FXR agonist with EC50 values of 42.2 nM (TR-FRET) and 176.4 nM (luciferase reporter assay). It can activate TGR5 (EC50 = 2.6 μM) but does not activate hMRGPRX4. FXR agonist17 exhibits anti-inflammatory, hepatoprotective, and antifibrotic effects, improving the activity score of metabolic dysfunction-associated fatty liver disease (NAFLD) and reducing the severity of liver fibrosis. This compound is applicable for research in NAFLD, cholestatic liver diseases, and liver fibrosis.

Fórmula: C₂₉H₄₆N₂O₃S

Peso molecular: 502.75

Ref: TM-T219141