CAS 315-22-0

Monocrotalina

Descripción:

Monocrotalina es un alcaloide que se encuentra de forma natural, derivado principalmente de la especie vegetal *Crotalaria* y es conocido por sus propiedades tóxicas. Pertenece a la clase de los alcaloides pirrolizidínicos, que se caracterizan por una estructura bicíclica que contiene un anillo de pirrolizidina. Monocrotalina exhibe hepatotoxicidad y puede causar hipertensión pulmonar, lo que lo convierte en un tema de interés en toxicología y farmacología. Se sabe que el compuesto sufre activación metabólica en el hígado, lo que lleva a la formación de metabolitos reactivos que pueden dañar las estructuras celulares, particularmente en el hígado y los pulmones. Su mecanismo de acción implica la formación de aductos de ADN, que pueden resultar en efectos mutagénicos. Debido a su naturaleza tóxica, Monocrotalina se estudia a menudo en el contexto de la salud y seguridad ambiental, particularmente en relación con los riesgos de exposición asociados con ciertas plantas. Además, se ha utilizado en investigaciones para modelar la hipertensión pulmonar en estudios con animales, proporcionando información sobre los mecanismos de la enfermedad y posibles enfoques terapéuticos.

Fórmula: C₁₆H₂₃NO₆

InChI: InChI=1/C16H23NO6/c1-9-13(18)23-11-5-7-17-6-4-10(12(11)17)8-22-14(19)16(3,21)15(9,2)20/h4,9,11-12,20-21H,5-8H2,1-3H3/p+1/t9-,11+,12+,15+,16-/m0/s1

Clave InChI: InChIKey=QVCMHGGNRFRMAD-XFGHUUIASA-N

SMILES: O=C1O[C@]2([C@@]3(N(CC2)CC=C3COC(=O)[C@](C)(O)[C@](C)(O)[C@H]1C)[H])[H]

Sinónimos:

• (13-alpha,14-alpha)-14,19-Dihydro-12,13-dihydroxy-20-norcrotalanan-11,15-dione
• (2,3,4-gh)pyrrolizine-2,6(3H)-dione, (4,5,8,10,12,13,13a,13b)-octahydro-4,5-dihydroxy-3,4,5-trimethyl-2H-(1,6)dioxacycloundecino-
• (3R,4R,5R,13aR)-4,5-dihydroxy-3,4,5-trimethyl-4,5,8,10,12,13,13a,13b-octahydro-2H-[1,6]dioxacycloundecino[2,3,4-gh]pyrrolizine-2,6(3H)-dione
• (3R,4R,5R,13aR,13bR)-4,5,8,10,12,13,13a,13b-Octahydro-4,5-dihydroxy-3,4,5-trimethyl-2H-[1,6]dioxacycloundecino[2,3,4-gh]pyrrolizine-2,6(3H)-dione
• (3R,4R,5R,13aR,13bR)-4,5-dihydroxy-3,4,5-trimethyl-2,6-dioxo-3,4,5,6,8,10,12,13,13a,13b-decahydro-2H-[1,6]dioxacycloundecino[2,3,4-gh]pyrrolizin-11-ium
• (3R,4R,5R,13aR,13bR)-4,5-dihydroxy-3,4,5-trimethyl-4,5,8,10,12,13,13a,13b-octahydro-2H-[1,6]dioxacycloundecino[2,3,4-gh]pyrrolizine-2,6(3H)-dione
• (3R,4R,5R,13aR,13bS)-4,5-dihydroxy-3,4,5-trimethyl-2,6-dioxo-3,4,5,6,8,10,12,13,13a,13b-decahydro-2H-[1,6]dioxacycloundecino[2,3,4-gh]pyrrolizin-11-ium
• (3R,4S,5R,13aR,13bR)-4,5-dihydroxy-3,4,5-trimethyl-4,5,8,10,12,13,13a,13b-octahydro-2H-[1,6]dioxacycloundecino[2,3,4-gh]pyrrolizine-2,6(3H)-dione
• (3S,4S,5S,13aS,13bS)-4,5-dihydroxy-3,4,5-trimethyl-4,5,8,10,12,13,13a,13b-octahydro-2H-[1,6]dioxacycloundecino[2,3,4-gh]pyrrolizine-2,6(3H)-dione
• 12-beta,13-beta-Dihydroxy-12-alpha,13-alpha,14-alpha-trimethylcrotal-1-enine
• 14,19-Dihydro-12,13-dihydroxy(13-alpha,14-alpha)-20-norcrotalanan-11,15-dione
• 14,19-Dihydro-12,13-dihydroxy-20-norcrotolanan-11,15-dione
• 20-Norcrotalanan-11,15-dione, 14,19-dihydro-12,13-dihydroxy-, (13-alpha,14-alpha)-
• 20-Norcrotalanan-11,15-dione, 14,19-dihydro-12,13-dihydroxy-, (13-alpha,14-alpha)- (9CI)
• 20-Norcrotalanan-11,15-dione, 14,19-dihydro-12,13-dihydroxy-, (13alpha,14alpha)-
• 20-Norcrotalanan-11,15-dione, 14,19-dihydro-12,13-dihydroxy-, (13α,14α)-
• 2H-(1,6)Dioxacycloundecino(2,3,4-gh)pyrrolizine-2,6(3H)-dione, 4,5,8,10,12,13,13a,13b-octahydro-4,5-dihydroxy-3,4,5-trimethyl-, (3R,4R,5R,13aR,13bR)-
• 2H-[1,6]Dioxacycloundecino[2,3,4-gh]pyrrolizine, 20-norcrotalanan-11,15-dione deriv.
• 2H-[1,6]Dioxacycloundecino[2,3,4-gh]pyrrolizine-2,6(3H)-dione, 4,5,8,10,12,13,13a,13b-octahydro-4,5-dihydroxy-3,4,5-trimethyl-, [3R-(3R*,4R*,5R*,13aR*,13bR*)]-
• A 6080
• Brn 0048732
• Ccris 416
• Crotaline
• Hsdb 3513
• Monocrotalin
• Nci-C56462
• Nsc 28693
• Retronecine cyclic 2,3-dihydroxy-2,3,4-trimethylglutarate
• Monocrotaline
• 4-27-00-06660 (Beilstein Handbook Reference)
• 4,5-Dihydroxy-3,4,5-trimethyl-4,5,8,10,12,13,13a,13b-octahydro-2H-[1,6]dioxacycloundecino[2,3,4-gh]pyrrolizine-2,6(3H)-dione
• MONOCROTOLLINE (99%)
• Bulbus Lilii
• Monocrotoline
• CROTALIN
• (13-alpha,14-alpha)-14,19-dihydro-12,13-dihydroxy-20-norcrotalanan-11,15-dio
• Monocrotaline/crotaline
• Monocrotaline, >=98%
• MONOCRATALINE
• Monccrotalire
• (2,3,4-gh)pyrrolizine-2,6(3h)-dione,(4,5,8,10,12,13,1
• Monocrotalinum
• 14,19-Dihydro-12,13-dihydroxy(13alpha,14alpha)-20-norcrotalanan-11,15-dione
• MONOCROTALIN(CROTALIN)(RG)
• 5-trimethyl-2h-(1,6)dioxacycloundecino-droxy-4
• 20-norcrotalanan-11,15-dione,14,19-dihydro-12,13-dihydroxy-,(13-alpha,14-al
• (2,3,4-gh)pyrrolizine-2,6(3h)-dione,(4,5,8,10,12,13,13a,13b-octahydro-4,5-dihy
• Crotaline,Monocrotaline
• Monocrotaline,99%
• (13R,14R)-14,19-Dihydro-12,13-dihydroxy-20-norcrotalanan-11,15-dione

Monocrotalin

CAS: 315-22-0

Monocrotalin analytical standard provided with chromatographic purity, to be used as reference material for qualitative determination.

Fórmula: C₁₆H₂₃NO₆

Pureza: (HPLC) ≥90%

Forma y color: Powder

Peso molecular: 325.37

Ref: 11-7351

Monocrotaline

CAS: 315-22-0

Monocrotaline

Fórmula: C₁₆H₂₃NO₆

Pureza: ≥95%

Peso molecular: 325.36

Ref: 54-BUP15752

(3R,4R,5R,8A1R,13Ar)-4,5-Dihydroxy-3,4,5-Trimethyl-4,5,8,8A1,10,12,13,13A-Octahydro-2H-[1,6]Dioxacycloundecino[2,3,4-Gh]Pyrrolizine-2,6(3H)-Dione

CAS: 315-22-0

(3R,4R,5R,8A1R,13Ar)-4,5-Dihydroxy-3,4,5-Trimethyl-4,5,8,8A1,10,12,13,13A-Octahydro-2H-[1,6]Dioxacycloundecino[2,3,4-Gh]Pyrrolizine-2,6(3H)-Dione

Fórmula: C₁₆H₂₃NO₆

Pureza: 98%

Peso molecular: 325.36

Ref: 54-OR1026386

Monocrotaline

CAS: 315-22-0

Fórmula: C₁₆H₂₃NO₆

Pureza: 97%

Forma y color: Solid

Peso molecular: 325.3569

Ref: IN-DA00BYAV

Monocrotaline (Crotaline)

CAS: 315-22-0

Fórmula: C₁₆H₂₃NO₆

Peso molecular: 325.36

Ref: 4Z-M-167001

Crotaline

CAS: 315-22-0

Fórmula: C₁₆H₂₃NO₆

Pureza: ≥ 98.0%

Forma y color: White to off-white crystalline powder

Peso molecular: 325.36

Ref: 7W-GX1396

Monocrotaline

Producto controlado

CAS: 315-22-0

Fórmula: C₁₆H₂₃NO₆

Forma y color: Neat

Peso molecular: 325.36

Ref: 04-C15298000

Monocrotaline

CAS: 315-22-0

Fórmula: C₁₆H₂₃NO₆

Pureza: 99%

Peso molecular: 325.361

Ref: BP-BP0957

Monocrotaline-d3

CAS: 315-22-0

Fórmula: C₁₆H₂₀D₃NO₆

Peso molecular: 328.38

Ref: 4Z-M-167003

Monocrotaline

CAS: 315-22-0

Monocrotaline (Crotaline) is a pyrrolizidine alkaloid and has certain cellular activity against HepG2 cells.Cost-effective and quality-assured.

Fórmula: C₁₆H₂₃NO₆

Pureza: 98% - 99.94%

Forma y color: White Solid

Peso molecular: 325.36

Ref: TM-T2803

Monocrotaline

CAS: 315-22-0

Natural alkaloid

Fórmula: C₁₆H₂₃NO₆

Pureza: ≥ 95.0 % (HPLC)

Forma y color: Powder

Peso molecular: 325.36

Ref: 5G-89251

Monocrotaline

CAS: 315-22-0

Applications A toxic pyrrolizidine alkaloid isolated from Crotalaria spp. It is used for inducing pulmonary diseases in rats.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Newberne, P.M., et al.: Toxicol. Appl. Pharmacol., 18, 387 (1971), Bober, M.A., et al.: Toxicon, 27, 1059 (1989), Wilson, D.W., et al.: Crit. Rev. Toxicol., 22, 307 (1992),

Fórmula: C₁₆H₂₃NO₆

Forma y color: Neat

Peso molecular: 325.36

Ref: TR-M526000

Monocrotaline

CAS: 315-22-0

Toxin; induces pulmonary hypertension

Fórmula: C₁₆H₂₃NO₆

Pureza: Min. 98%

Forma y color: White Off-White Clear Liquid

Peso molecular: 325.36 g/mol

Ref: 3D-FM64904

Monocrotaline

CAS: 315-22-0

Ref: BE-RMT21150

Monocrotaline

CAS: 315-22-0

Ref: BE-RMCM244001

Monocrotaline

CAS: 315-22-0

Fórmula: C₁₆H₂₃NO₆

Pureza: 95%

Forma y color: Solid

Peso molecular: 325.361

Ref: 10-F002602

Monocrotaline-d4

Producto controlado

CAS: 315-22-0

Applications Monocrotaline-d4 is labelled Monocrotaline (M526000) which is a toxic pyrrolizidine alkaloid isolated from Crotalaria spp. It is used for inducing pulmonary diseases in rats.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Newberne, P.M., et al.: Toxicol. Appl. Pharmacol., 18, 387 (1971), Bober, M.A., et al.: Toxicon, 27, 1059 (1989), Wilson, D.W., et al.: Crit. Rev. Toxicol., 22, 307 (1992),

Fórmula: C₁₆D₄H₁₉NO₆

Forma y color: Neat

Peso molecular: 329.382

Ref: TR-M526002

Monocrotaline

CAS: 315-22-0

Fórmula: C₁₆H₂₃NO₆

Peso molecular: 325.36

Ref: ST-EA-CP-M160000