CAS 31618-90-3

dietil (tosiloxi)metilfosfonato

Descripción:

dietil (tosiloxi)metilfosfonato, con el número CAS 31618-90-3, es un compuesto organofosforado caracterizado por su estructura de fosfonato, que incluye un átomo de fósforo unido a un átomo de oxígeno y un grupo alquilo. Este compuesto presenta dos grupos etilo y un grupo tosilo, que mejora su reactividad y solubilidad en disolventes orgánicos. Típicamente es un líquido incoloro a amarillo pálido y es conocido por sus aplicaciones en la síntesis orgánica, particularmente como reactivo en la preparación de varios fosfonatos y fosfonamidatos. La presencia del grupo tosilo contribuye a su naturaleza electrofílica, haciéndolo útil en reacciones de sustitución nucleofílica. Además, dietil (tosiloxi)metilfosfonato puede exhibir toxicidad moderada, común entre los compuestos organofosforados, lo que requiere un manejo cuidadoso y medidas de seguridad adecuadas durante su uso. Sus propiedades químicas, incluyendo estabilidad y reactividad, lo convierten en un intermediario valioso en la síntesis de productos farmacéuticos y agroquímicos.

Fórmula: C₁₂H₁₉O₆PS

InChI: InChI=1/C12H19O6PS/c1-4-16-19(13,17-5-2)10-18-20(14,15)12-8-6-11(3)7-9-12/h6-9H,4-5,10H2,1-3H3

Clave InChI: InChIKey=UOEFFQWLRUBDME-UHFFFAOYSA-N

SMILES: S(OCP(OCC)(OCC)=O)(=O)(=O)C1=CC=C(C)C=C1

Sinónimos:

• (Diethoxyphosphoryl)Methyl 4-Methylbenzenesulfonate
• 4-Methylbenzenesulfonic acid (diethoxyphosphoryl)methyl ester
• Desmp
• Detp
• Diethoxyphosphorylmethyl tosylate
• Diethyl P-Toluenesulfonyl Oxymethyl Phosphonate
• Diethyl P-Tosyloxymethylphosphonate
• Diethyl P-[[[(4-methylphenyl)sulfonyl]oxy]methyl]phosphonate
• Diethyl [[(P-Toluenesulfonyl)Oxy]Methyl]Phosphonate
• Diethyl [[[(4-Tolyl)Sulfonyl]Oxy]Methyl]Phosphonate
• Diethyl p-toluene sulfonyl oxymethyl phosphonate
• Diethyl p-toluene sulfonyloxy methyl phosphonate
• Diethyl  p-toluenesulfonyloxymethylphosphonate
• PMPA monohydrate
• Phosphonic acid, (hydroxymethyl)-, diethyl ester, p-toluenesulfonate
• Phosphonic acid, P-[[[(4-methylphenyl)sulfonyl]oxy]methyl]-, diethyl ester
• Phosphonic acid, [[[(4-methylphenyl)sulfonyl]oxy]methyl]-, diethyl ester
• Tosyloxymethyl Diethyl Phosphonate
• [[[(4-Tolyl)Sulfonyl]Oxy]Methyl]Phosphonic Acid Diethyl Ester
• Diethyl(tosyloxy)methylphosphonate
• Diethyl p-toluene sulfonyloxy methyl phosphonate(DESMP)
• PHOSPHONIC ACID, [[[(4-METHYLPHENYL)SULFONYL]OXY]METHYL]-, DIETHYL ESTER (9CI)
• Diethylp-toluenesulfonyloxymenthylphosphonate
• p-toluenesulfonyloxy methylphosphonate
• DIETHYL 4-TOLUENESULFONYLOXYMETHYLPHOSPHONATE
• DETHYL (TOSYLOXY) METHYLPHOSPHONATE
• TOLUENE-4-SULFONIC ACID DIETHOXY-PHOSPHORYLMETHYL ESTER
• DIETHYL(TOSYLOXYMETHYL)PHOSPHONATE
• Diethyl(Tosyloxy)methylphosphonte
• 4-METHYLPHENYL]SULFONYL]OXY]METHYLPHOSPHONICACIDDIETHYLESTER

Diethyl (p-Toluenesulfonyloxymethyl)phosphonate

CAS: 31618-90-3

Fórmula: C₁₂H₁₉O₆PS

Pureza: >97.0%(GC)

Forma y color: Colorless to Light yellow clear liquid

Peso molecular: 322.31

Ref: 3B-D4968

(Diethoxyphosphoryl)methyl 4-methylbenzenesulfonate

CAS: 31618-90-3

Fórmula: C₁₂H₁₉O₆PS

Pureza: 98%

Forma y color: Liquid

Peso molecular: 322.3144

Ref: IN-DA0034QG

Diethyl(tosyloxy)methylphosphonate

CAS: 31618-90-3

Diethyl(tosyloxy)methylphosphonate

Fórmula: C₁₂H₁₉O₆PS

Pureza: 98%

Forma y color: Solid-Low Melt

Peso molecular: 322.31442

Ref: 54-OR53035

Tenofovir Impurity 36

CAS: 31618-90-3

Fórmula: C₁₂H₁₉O₆PS

Peso molecular: 322.31

Ref: 4Z-T-0280

(Diethoxyphosphoryl)methyl 4-methylbenzenesulfonate

CAS: 31618-90-3

(Diethoxyphosphoryl)methyl 4-methylbenzenesulfonate

Fórmula: C₁₂H₁₉O₆PS

Pureza: 98%

Peso molecular: 322.31

Ref: IN-DG41587

Tenofovir Impurity 66

CAS: 31618-90-3

Fórmula: C₁₂H₁₉O₆PS

Peso molecular: 322.31

Ref: ST-EA-CP-T5013

Diethyl p-tosyloxymethylphosphonate

CAS: 31618-90-3

Diethyl p-tosyloxymethylphosphonate is an organic compound that is used in the synthesis of tenofovir. It is a salt of diethyl phosphate and p-toluenesulfonyl chloride, which reacts with magnesium chloride to form diethyl p-tosyloxymethylphosphonate. Diethyl p-tosyloxymethylphosphonate is also used as a reagent for the acylation reaction of phosphites and chlorides. This reaction has been shown to be useful in the synthesis of many organic compounds, including drugs such as methyldopa and acetazolamide. Diethyl p-tosyloxymethylphosphonate has also been shown to have anti-cancer properties. The mechanism of this effect is not well understood, but it may be due to inhibition of DNA replication or the induction of apoptosis by reactive oxygen species (ROS).

Fórmula: C₁₂H₁₉O₆PS

Pureza: Min. 95%

Forma y color: Colorless Clear Liquid

Peso molecular: 322.32 g/mol

Ref: 3D-FD10108

(Diethoxyphosphoryl)methyl 4-methylbenzenesulfonate

CAS: 31618-90-3

Fórmula: C₁₂H₁₉O₆PS

Pureza: 97%

Forma y color: White powder

Peso molecular: 322.31

Ref: 10-F213393

Diethyl p-Toluenesulfonyloxymethylphosphonate

Producto controlado

CAS: 31618-90-3

Applications Diethyl p-Toluenesulfonyloxymethylphosphonate is an antiviral agent and a Tenofovir (T018500) intermediate. Tenofovir is an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor used as an anti-HIV agent.
References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997), Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007),

Fórmula: C₁₂H₁₉O₆PS

Forma y color: Neat

Peso molecular: 322.31

Ref: TR-D445260