CAS 33419-42-0: Etopósido

Descripción: Etopósido es un agente quimioterapéutico utilizado principalmente en el tratamiento de varios tipos de cáncer, incluyendo el cáncer testicular y el cáncer de pulmón de células pequeñas. Se clasifica como un inhibidor de la topoisomerasa II, lo que significa que interfiere con la enzima responsable de la replicación y reparación del ADN, lo que finalmente conduce a la muerte de las células cancerosas. Etopósido se administra típicamente por vía intravenosa u oral y es conocido por su efectividad en combinación con otros fármacos de quimioterapia. El compuesto tiene una fórmula molecular de C21H22O8 y un peso molecular de aproximadamente 366.39 g/mol. Etopósido se caracteriza por su capacidad para inducir apoptosis en las células cancerosas, lo que lo convierte en una herramienta valiosa en oncología. Sin embargo, también puede causar efectos secundarios, incluyendo mielosupresión, trastornos gastrointestinales y un mayor riesgo de malignidades secundarias. Debido a su mecanismo de acción, el monitoreo y la gestión cuidadosa de la dosis son esenciales para minimizar la toxicidad mientras se maximiza la eficacia terapéutica. En general, Etopósido sigue siendo un agente importante en el arsenal contra ciertas malignidades.

Fórmula: C₂₉H₃₂O₁₃

InChI: InChI=1S/C29H32O13/c1-11-36-9-20-27(40-11)24(31)25(32)29(41-20)42-26-14-7-17-16(38-10-39-17)6-13(14)21(22-15(26)8-37-28(22)33)12-4-18(34-2)23(30)19(5-12)35-3/h4-7,11,15,20-22,24-27,29-32H,8-10H2,1-3H3/t11-,15+,20-,21-,22+,24-,25-,26-,27-,29+/m1/s1

Clave InChI: InChIKey=VJJPUSNTGOMMGY-MRVIYFEKSA-N

SMILES: O=C1OCC2C(OC3OC4COC(OC4C(O)C3O)C)C5=CC=6OCOC6C=C5C(C7=CC(OC)=C(O)C(OC)=C7)C12

Sinónimos:

• (5R,5aR,8aR,9S)-9-[[4,6-O-(1R)-Ethylidene-β-<span class="text-smallcaps">D</span>-glucopyranosyl]oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
• (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-[(1R)-ethylidene]-alpha-L-gulopyranoside
• (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-[(1R)-ethylidene]-beta-D-mannopyranoside
• (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-[(1S)-ethylidene]-alpha-L-gulopyranoside
• (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-[(1S)-ethylidene]-beta-D-mannopyranoside
• (8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside
• 4'-Demethyl-1-O-[4,6-O-(ethylidene)-β-D-glucopyranosyl]epipodophyllotoxin
• 4'-Demethylepipodophyllotoxin 9-(4,6-O-ethylidene-β-D-glucopyranoside)
• 4'-Demethylepipodophyllotoxin ethylidene-β-D-glucoside
• 4'-Demethylepipodophyllotoxin-(4,6-O-(R)-Ethylidene-Beta-D-Glucopyranoside)
• 4-Demethylepipodophyllotoxin-Beta-D-Ethylideneglucoside
• 4′-Demethyl-1-O-[4,6-O-(ethylidene)-β-<span class="text-smallcaps">D</span>-glucopyranosyl]epipodophyllotoxin
• 4′-Demethylepipodophyllotoxin 9-(4,6-O-ethylidene-β-<span class="text-smallcaps">D</span>-glucopyranoside)
• 4′-Demethylepipodophyllotoxin ethylidene-β-<span class="text-smallcaps">D</span>-glucoside
• Beposid
• Bioposide
• Celltop
• EPE
• Epipodophyllotoxin VP 16213
• Epipodophyllotoxin, 4'-demethyl-, 4,6-O-ethylidene-β-D-glucopyranoside
• Epipodophyllotoxin, 4′-demethyl-, 4,6-O-ethylidene-β-<span class="text-smallcaps">D</span>-glucopyranoside
• Eposed
• Eposin
• Ethopul
• Eto-Gry
• Etoposid
• Etoposido
• Etosid
• Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 9-[(4,6-O-ethylidene-β-D-glucopyranosyl)oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-, [5R-[5α,5aβ,8aα,9β(R*)]]-
• Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 9-[[4,6-O-(1R)-ethylidene-β-D-glucopyranosyl]oxy]-5,8,8a,9-tetrahy dro-5-(4-hydroxy-3,5-dimethoxyphenyl)-, (5R,5aR,8aR,9S)-
• Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 9-[[4,6-O-(1R)-ethylidene-β-D-glucopyranosyl]oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-, (5R,5aR,8aR,9S)-
• Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 9-[(4,6-O-ethylidene-β-<span class="text-smallcaps">D</span>-glucopyranosyl)oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-, [5R-[5α,5aβ,8aα,9β(R*)]]-
• Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 9-[[4,6-O-(1R)-ethylidene-β-<span class="text-smallcaps">D</span>-glucopyranosyl]oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-, (5R,5aR,8aR,9S)-
• Fytop
• Fytosid
• Lastet
• Nsc 141540
• Nzytop
• Pyrano[3,2-d]-1,3-dioxin, furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one deriv.
• Sintopozid
• Topok
• Toposar
• Toposide
• VP 16 (pharmaceutical)
• VePesid
• Vepesid J
• Vp 16
• Vp 16-123
• Vp 16-213
• Zuyeyidal
• trans-Etoposide
• Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 9-[(4,6-O-ethylidene-β-D-glucopyranosyl)oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-, [5R-[5α,5aβ,8aα,9β(R*)]]-
• (5R,5aR,8aR,9S)-9-[[4,6-O-(1R)-Ethylidene-β-D-glucopyranosyl]oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
• Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 9-[[4,6-O-(1R)-ethylidene-β-D-glucopyranosyl]oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-, (5R,5aR,8aR,9S)-

Etoposide

CAS: 33419-42-0

• Fórmula: C₂₉H₃₂O₁₃
• Pureza: >98.0%(HPLC)
• Forma y color: White to Almost white powder to crystal
• Peso molecular: 588.56

Etoposide

CAS: 33419-42-0

Etoposide is used as a inhibits DNA synthesis and is very active against cells in …

• Fórmula: C₂₉H₃₂O₁₃
• Forma y color: Powder or crystals or crystalline powder
• Peso molecular: 588.56

Etoposide for system suitability CRS

CAS: 33419-42-0

• Fórmula: C₂₉H₃₂O₁₃
• Peso molecular: 588.5566

Etoposide CRS

CAS: 33419-42-0

• Fórmula: C₂₉H₃₂O₁₃
• Forma y color: Crystalline Powder. White. Powder.
• Peso molecular: 588.5566

Etoposide

CAS: 33419-42-0

Other glycosides, natural or reproduced by synthesis, and their salts, ethers, esters and other derivatives

• Fórmula: C₂₉H₃₂O₁₃
• Forma y color: White Off-White Powder
• Peso molecular: 588.18429

Etoposide

CAS: 33419-42-0

Etoposide (VP-16-213) is a topoisomerase II inhibitor that inhibits DNA synthesis by forming a complex …

• Fórmula: C₂₉H₃₂O₁₃
• Pureza: 99.19% - 99.94%
• Forma y color: Crystals From Methanol Solid
• Peso molecular: 588.56

(5R,5aR,8aR,9S)-9-[[4,6-O-(1R)-Ethylidene-β-D-glucopyranosyl]oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one

CAS: 33419-42-0

• Fórmula: C₂₉H₃₂O₁₃
• Pureza: 98%
• Forma y color: Solid
• Peso molecular: 588.5566

Etoposide

CAS: 33419-42-0

• Fórmula: C₂₉H₃₂O₁₃
• Pureza: (HPLC) ≥ 98.0%
• Forma y color: White or almost white crystalline powder
• Peso molecular: 588.56

Etoposide, USP grade

CAS: 33419-42-0

• Fórmula: C₂₉H₃₂O₁₃
• Pureza: (anhydrous basis) 95.0 - 105.0 %
• Forma y color: White or almost white crystalline powder
• Peso molecular: 588.56

Etoposide-13C-d3

CAS: 33419-42-0

• Fórmula: C₂₈₁₃CH₂₉D₃O₁₃
• Forma y color: Off-White Solid
• Peso molecular: 592.57

Etoposide

CAS: 33419-42-0

• Fórmula: C₂₉H₃₂O₁₃
• Forma y color: Neat
• Peso molecular: 588.56

Etoposide

CAS: 33419-42-0

Etoposide is a chemotherapy medication used for the treatments of a number of types of …

• Fórmula: C₂₉H₃₂O₁₃
• Pureza: 95%~99%
• Peso molecular: 588.562

Etoposide

CAS: 33419-42-0

• Fórmula: C₂₉H₃₂O₁₃
• Forma y color: Neat
• Peso molecular: 588.56

Etoposide

CAS: 33419-42-0

• Fórmula: C₂₉H₃₂O₁₃
• Forma y color: White To Off-White Solid
• Peso molecular: 588.56

Etoposide

CAS: 33419-42-0

• Fórmula: C₂₉H₃₂O₁₃
• Pureza: By hplc: 99.51% by area. (Typical Value in Batch COA)
• Forma y color: pale yellow solid
• Peso molecular: 588.56g/mol

Etoposide RS

CAS: 33419-42-0

• Forma y color: White

Etoposide-d3

CAS: 33419-42-0

Applications A labelled DNA topoisomerase II inhibitor. Semi-synthetic derivative of podophyllotoxin, related structurally to Teniposide. …

• Fórmula: C₂₉H₂₉D₃O₁₃
• Forma y color: Neat
• Peso molecular: 591.58

Etoposide-d4

CAS: 33419-42-0

Applications Etoposide-d4, is the labeled analogue of Etoposide (E933750), a DNA topoisomerase II inhibitor. Semi-synthetic …

• Fórmula: C₂₉H₂₈D₄O₁₃
• Forma y color: Neat
• Peso molecular: 592.58

Etoposide

CAS: 33419-42-0

• Fórmula: C₂₉H₃₂O₁₃
• Forma y color: Off-White
• Peso molecular: 588.56

Etoposide

CAS: 33419-42-0

Etoposide is a cytotoxic drug used in cancer chemotherapy. It inhibits DNA replication through inhibition …

• Fórmula: C₂₉H₃₂O₁₃
• Pureza: Min. 98 Area-%
• Forma y color: White Powder
• Peso molecular: 588.55 g/mol