CAS 3432-99-3
:Ácido 5,10-metileno-5,6,7,8-tetrahidrofólico
Descripción:
Ácido 5,10-metileno-5,6,7,8-tetrahidrofólico, comúnmente conocido como metilentetrahidrofolato, es un derivado del folato, una vitamina B esencial para varios procesos biológicos. Este compuesto juega un papel crucial en el metabolismo de un carbono, particularmente en la síntesis de nucleótidos y aminoácidos, que son vitales para la replicación y reparación del ADN. Se caracteriza por su estructura de tetrahidrofolato, que incluye un anillo de pteridina, ácido para-aminobenzoico y una cola de ácido glutámico. El grupo metileno en la posición 5,10 es significativo para su función en la transferencia de unidades de un carbono. Este compuesto es soluble en agua y generalmente está involucrado en reacciones enzimáticas catalizadas por la metilentetrahidrofolato reductasa (MTHFR). Las deficiencias en este compuesto pueden llevar a varios problemas de salud, incluyendo anemia megaloblástica y niveles elevados de homocisteína, que están asociados con enfermedades cardiovasculares. Su papel en el metabolismo celular y su participación en el ciclo de metilación subrayan su importancia en la salud y nutrición humanas.
Fórmula:C20H23N7O6
InChI:InChI=1/C20H23N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,12-13H,5-9H2,(H,23,30)(H,28,29)(H,32,33)(H4,21,22,24,25,31)/t12?,13-/m0/s1
Clave InChI:InChIKey=QYNUQALWYRSVHF-ABLWVSNPSA-N
SMILES:O=C1C=2N3C(CN(C3)C4=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C4)(CNC2NC(N)=N1)[H]
Sinónimos:- (+)-5,10-Methylene-5,6,7,8-tetrahydrofolic acid
- (2s)-2-(4-(3-Amino-1-oxo-5,6,6a,7-tetrahydroimidazo[1,5-f]pteridin-8(1H,4H,9H)-yl)benzamido)pentanedioic acid
- 5,10-Methylene-(6RS)-tetrahydrofolic acid
- 5,10-Methylenetetrafolate
- 5,10-Methylenetetrahydrofolic acid
- <span class="text-smallcaps">L</span>-Glutamic acid, N-[4-(3-amino-1,2,5,6,6a,7-hexahydro-1-oxoimidazo[1,5-f]pteridin-8(9H)-yl)benzoyl]-
- Anx-510
- Folic acid, tetrahydro-N<sup>5</sup>,N<sup>10</sup>-methylene-
- Folitixorin
- Glutamic acid, N-[p-(3-amino-5,6,6a,7-tetrahydro-1-hydroxyimidazo[1,5-f]pteridin-8(9H)-yl)benzoyl]-, <span class="text-smallcaps">L</span>-
- Imidazo[1,5-f]pteridine, <span class="text-smallcaps">L</span>-glutamic acid deriv.
- L-glutamic acid, N-[4-(3-amino-5,6,6a,7-tetrahydro-1-hydroxyimidazo[1,5-f]pteridin-8(9H)-yl)benzoyl]-
- N-[4-(3-Amino-1,2,5,6,6a,7-hexahydro-1-oxoimidazo[1,5-f]pteridin-8(9H)-yl)benzoyl]-<span class="text-smallcaps">L</span>-glutamic acid
- N-[4-(3-amino-1-hydroxy-5,6,6a,7-tetrahydroimidazo[1,5-f]pteridin-8(9H)-yl)benzoyl]-L-glutamic acid
- N-{4-[(6aR)-3-amino-1-oxo-1,4,5,6,6a,7-hexahydroimidazo[1,5-f]pteridin-8(9H)-yl]benzoyl}-L-glutamic acid
- N<sup>5</sup>,N<sup>10</sup>-Methylene-5,6,7,8-tetrahydrofolic acid
- N<sup>5</sup>,N<sup>10</sup>-Methylenetetrahydrofolic acid
- N<sup>5</sup>,N<sup>10</sup>-Methylenetetrahydropteroylglutamic acid
- Imidazo[1,5-f]pteridine, L-glutamic acid deriv.
- Folic acid, tetrahydro-N5,N10-methylene-
- Glutamic acid, N-[p-(3-amino-5,6,6a,7-tetrahydro-1-hydroxyimidazo[1,5-f]pteridin-8(9H)-yl)benzoyl]-, L-
- L-Glutamic acid, N-[4-(3-amino-1,2,5,6,6a,7-hexahydro-1-oxoimidazo[1,5-f]pteridin-8(9H)-yl)benzoyl]-
- N-[4-(3-Amino-1,2,5,6,6a,7-hexahydro-1-oxoimidazo[1,5-f]pteridin-8(9H)-yl)benzoyl]-L-glutamic acid
- 5,10-METHYLENETETRAHYDROFOLICACID
- N5,N10-Methyl-
- N5,N10-MethylenetetrahydropteroylglutaMic Acid
- Levofolinate Methylene Impurity
- enetetrahydrofolic Acid
- N-[4-[(3-Amino-1,2,5,6,6a,7,8,9-octahydro-1-oxoimidazo[1,5-f]pteridin)-8-yl]benzoyl]-L-glutamic acid
- (Mixture of Diastereomers)
- Folic Acid Impurity 13 Monomer
- Folitixorin (~80%)
- Ver más sinónimos
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Encontrado 8 productos.
5,10-METHYLENETETRAHYDROFOLATE
CAS:Fórmula:C20H23N7O6Pureza:95%Forma y color:SolidPeso molecular:457.4399(2S)-2-(4-(3-Amino-1-oxo-1,2,5,6,6a,7-hexahydroimidazo[1,5-f]pteridin-8(9H)-yl)benzamido)pentanedioic acid
CAS:(2S)-2-(4-(3-Amino-1-oxo-1,2,5,6,6a,7-hexahydroimidazo[1,5-f]pteridin-8(9H)-yl)benzamido)pentanedioic acidPureza:95%Peso molecular:457.45g/molCalcium Folinate EP Impurity I (Folitixorin) (Mixture of Diastereomers)
CAS:Fórmula:C20H23N7O6Peso molecular:457.45Folitixorin (~80%)(Mixture of Diastereomers)
CAS:<p>Stability Hygroscopic, Moisture Sensitive, Temperature Sensitive<br>Applications A stable folate lyophilized compound suitable for use in the treatment of cancer and other therapies.<br>References Park, H., et al.: Science, 268, 1866 (1995), Banerjee, R., et al.: J. Biol. Chem., 282, 14916 (2007), Klar, T., et al.: J. Mol. Biol., 366, 954 (2007),<br></p>Fórmula:C20H23N7O6Forma y color:NeatPeso molecular:457.44Folitixorin-d4 Disodium Salt (>80%) (Mixture of Diastereomers)
CAS:Producto controladoFórmula:C20H17D4N7Na2O6Forma y color:NeatPeso molecular:505.435,10-Methylene-5,6,7,8-tetrahydrofolic acid - mixture of diastereomers
CAS:<p>5,10-Methylene-5,6,7,8-tetrahydrofolic acid is a molecule that is found in cells. It is an essential cofactor for many biological processes. The folate form of 5,10-methylene-5,6,7,8-tetrahydrofolic acid (5MTHF) can be synthesized by the enzyme methylenetetrahydrofolate reductase. This enzyme uses N5,N10-methenyltetrahydrofolate as a substrate and converts it to 5MTHF. The enzyme activity of methylenetetrahydrofolate reductase can be inhibited by methotrexate. In this case 5MTHF will not be produced and the body's supply of folate will decrease. The structural analysis of 5MTHF has been performed using titration calorimetry and x-ray crystallography.</p>Fórmula:C20H23N7O6Pureza:80%MinForma y color:PowderPeso molecular:457.44 g/molFolitixorin
CAS:Folitixorin (ANX-510) is an active folate derivative and coenzyme associated with thymidine synthesis, with potential antitumour activity.Fórmula:C20H23N7O6Pureza:95.94%Forma y color:SolidPeso molecular:457.44
![(2S)-2-(4-(3-Amino-1-oxo-1,2,5,6,6a,7-hexahydroimidazo[1,5-f]pteridin-8(9H)-yl)benzamido)pentanedi…](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F54%2Fthumb%2FOR1053159.jpg&w=3840&q=75)
