CAS 366789-02-8

Rivaroxabán

Descripción:

Rivaroxabán es un medicamento anticoagulante oral que se utiliza principalmente para la prevención y el tratamiento de trastornos tromboembólicos, como la trombosis venosa profunda y la embolia pulmonar. Funciona como un inhibidor directo del factor Xa, lo que interrumpe la cascada de coagulación y reduce la formación de coágulos sanguíneos. Rivaroxabán se caracteriza por su alta biodisponibilidad y farmacocinética predecible, lo que permite una dosificación fija sin necesidad de monitoreo rutinario de los parámetros de coagulación. La sustancia se administra típicamente en forma de tabletas y se absorbe rápidamente, con concentraciones plasmáticas máximas que ocurren dentro de unas pocas horas después de la ingestión. Se metaboliza principalmente en el hígado a través de las enzimas del citocromo P450 y se excreta a través de vías renales y fecales. Los efectos secundarios comunes pueden incluir complicaciones hemorrágicas, lo que requiere precaución en pacientes con ciertos factores de riesgo. El perfil de eficacia y seguridad de Rivaroxabán lo ha convertido en una opción ampliamente utilizada en la terapia anticoagulante, aunque está contraindicado en pacientes con hemorragia activa o deterioro renal severo.

Fórmula: C₁₉H₁₈ClN₃O₅S

InChI: InChI=1/C19H18ClN3O5S/c20-16-6-5-15(29-16)18(25)21-9-14-10-23(19(26)28-14)13-3-1-12(2-4-13)22-7-8-27-11-17(22)24/h1-6,14H,7-11H2,(H,21,25)/t14-/m0/s1

Clave InChI: InChIKey=KGFYHTZWPPHNLQ-AWEZNQCLSA-N

SMILES: O=C1N(C[C@H](CNC(=O)C=2SC(Cl)=CC2)O1)C3=CC=C(C=C3)N4C(=O)COCC4

Sinónimos:

• (S)-Rivaroxaban
• 2-Thiophenecarboxamide, 5-chloro-N-[[(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-
• 5-Chloro-N-(((5S)-2-oxo-3-(4-(3-oxomorpholin-4-yl)phenyl)-1,3-oxazolidin-5-yl)methyl)thiophene-2-carboxamide
• 5-Chloro-N-([(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl]-methyl)-2-thiophenecarboxamide
• 5-Chloro-N-[[(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-2-thiophenecarboxamide
• 5-Chloro-N-[[(S)-3-(4-(3-oxomorpholin-4-yl)phenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl]-thiophene-2-carboxamide
• 5-chloro-N-[[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]oxazolidin-5-yl]methyl]thiophene-2-carboxamide
• Bay 59-7939
• Rivaroxaban intermediates
• Rivaroxban
• Xarelto
• Rivaroxaban
• (S)-5-chloro-N-((2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)thiophene-2-carboxamide
• Rivaroxaban API
• Rivarobaxan
• Rivaroxaban(Xarelto)
• (S)-5-Chloro-N-((2-oxo-3-(4-(3-oxomorpholino)phenyl)-oxazolidin-5-yl)methyl)thiophene-2-carboxami
• Rivaroxaba

Rivaroxaban

CAS: 366789-02-8

Fórmula: C₁₉H₁₈ClN₃O₅S

Pureza: >98.0%(T)(HPLC)

Forma y color: White to Light yellow powder to crystal

Peso molecular: 435.88

Ref: 3B-R0269

RIVAROXABAN CRS

CAS: 366789-02-8

RIVAROXABAN CRS

Ref: 41-Y0002187

Rivaroxaban

CAS: 366789-02-8

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Fórmula: C₁₉H₁₈ClN₃O₅S

Forma y color: White Powder

Peso molecular: 435.06557

Ref: 45-1604530

Rivaroxaban

CAS: 366789-02-8

(S)-5-Chloro-N-((2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)thiophene-2-carboxamide

Fórmula: C₁₉H₁₈ClN₃O₅S

Pureza: 98%

Peso molecular: 435.88

Ref: IN-DG157897

Rivaroxaban

CAS: 366789-02-8

Rivaroxaban

Fórmula: C₁₉H₁₈ClN₃O₅S

Pureza: 99.50%

Forma y color: Solid

Peso molecular: 435.88

Ref: 54-OR1028886

Rivaroxaban

CAS: 366789-02-8

Rivaroxaban (BAY 59-7939) is an oral, direct factor Xa inhibitor with anticoagulant properties, interfering with thrombin formation.

Fórmula: C₁₉H₁₈ClN₃O₅S

Pureza: 99.93% - >99.99%

Forma y color: White Solid

Peso molecular: 435.88

Ref: TM-T1184

Rivaroxaban

CAS: 366789-02-8

Fórmula: C₁₉H₁₈ClN₃O₅S

Pureza: ≥ 98.0% (dried basis)

Forma y color: White to off-white powder

Peso molecular: 435.88

Ref: 7W-GP9456

Rivaroxaban

CAS: 366789-02-8

Fórmula: C₁₉H₁₈ClN₃O₅S

Forma y color: White To Off-White Solid

Peso molecular: 435.88

Ref: 4Z-R-291

Rivaroxaban

CAS: 366789-02-8

Rivaroxaban

Fórmula: C₁₉H₁₈ClN₃O₅S

Pureza: ≥98%

Peso molecular: 435.88

Ref: 54-BUP12991

Rivaroxaban

Producto controlado

CAS: 366789-02-8

Fórmula: C₁₉H₁₈ClN₃O₅S

Forma y color: Neat

Peso molecular: 435.88

Ref: 86-MM3629.00

Rivaroxaban (Standard)

CAS: 366789-02-8

Rivaroxaban (Standard) is a reference standard for research and analysis in studies involving Rivaroxaban. Rivaroxaban (BAY 59-7939) is an orally bioavailable oxazolidinone derivative and direct inhibitor of the coagulation factor Xa with anticoagulant activity. Upon oral administration, rivaroxaban selectively binds to both free factor Xa and factor Xa bound in the prothrombinase complex. This interferes with the conversion of prothrombin (factor II) to thrombin and eventually prevents the formation of cross-linked fibrin clots. Rivaroxaban does not affect existing thrombin levels.

Fórmula: C₁₉H₁₈ClN₃O₅S

Peso molecular: 435.88

Ref: TM-TMSM-3472

Rivaroxaban

CAS: 366789-02-8

Forma y color: Neat

Ref: 04-C16815330

Rivaroxaban

CAS: 366789-02-8

Fórmula: C₁₉H₁₈ClN₃O₅S

Peso molecular: 435.88

Ref: ST-EA-CP-R17000

Rivaroxaban

CAS: 366789-02-8

Applications A novel antithrombotic agent. A highly potent and selective, direct FXa inhibitor.
References Ansell, J., et al.: Drugs, 64, 1 (2004), Eriksson, B., et al.: J. Thromb. Haemost., 3, 103 (2005), Kubitza, D., et al.: Clin. Pharmacol. Ther., 78, 412 (2005),

Fórmula: C₁₉H₁₈ClN₃O₅S

Forma y color: Neat

Peso molecular: 435.88

Ref: TR-R538000

Rivaroxaban - Bio-X ™

CAS: 366789-02-8

Rivaroxaban is a natural drug that is a direct factor Xa inhibitor. It has been shown to be an effective therapy for the treatment of atrial fibrillation, deep vein thrombosis (DVT) and pulmonary embolism (PE). It works by inhibiting the enzyme, thrombin, which is responsible for the formation of blood clots. Rivaroxaban also has an effect on the coagulation system by decreasing the levels of fibrinogen and increases in antithrombin III. This drug does not have any specific antidote, but it can be reversed with heparin. Pharmacodynamics and drug interactions have been studied extensively in preclinical models, demonstrated by the concentration–time curves.

Fórmula: C₁₉H₁₈ClN₃O₅S

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 435.88 g/mol

Ref: 3D-BR164355

Rivaroxaban

CAS: 366789-02-8

Rivaroxaban is a natural drug that is a direct factor Xa inhibitor. It has been shown to be an effective therapy for the treatment of atrial fibrillation, deep vein thrombosis (DVT) and pulmonary embolism (PE). It works by inhibiting the enzyme, thrombin, which is responsible for the formation of blood clots. Rivaroxaban also has an effect on the coagulation system by decreasing the levels of fibrinogen and increases in antithrombin III. This drug does not have any specific antidote, but it can be reversed with heparin. Pharmacodynamics and drug interactions have been studied extensively in preclinical models, demonstrated by the concentration–time curves.

Fórmula: C₁₉H₁₈ClN₃O₅S

Pureza: Min. 98 Area-%

Forma y color: White Off-White Powder

Peso molecular: 435.88 g/mol

Ref: 3D-FR27742

5-chloro-N-{[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl]methyl}thiophene-2-carboxamide

CAS: 366789-02-8

Fórmula: C₁₉H₁₈ClN₃O₅S

Pureza: 99%

Forma y color: Solid

Peso molecular: 435.8813

Ref: IN-DA0035KL