CAS 4033-27-6

ácido dihidrofólico

Descripción:

ácido dihidrofólico, también conocido como 7,8-dihidrofolato, es un derivado de la vitamina B soluble en agua que desempeña un papel crucial en la síntesis de ácidos nucleicos y aminoácidos. Es un intermediario clave en la vía metabólica del folato, que es esencial para la división y el crecimiento celular. ácido dihidrofólico se caracteriza por su estructura, que incluye un anillo de pteridina, ácido para-aminobenzoico y residuos de ácido glutámico. Este compuesto se encuentra típicamente en el cuerpo como resultado de la reducción del ácido fólico, facilitada por la enzima dihidrofolato reductasa. Está involucrado en la conversión del folato dietético en sus formas activas, que son necesarias para la síntesis y reparación del ADN. ácido dihidrofólico también es significativo en farmacología, ya que ciertos antibióticos, como los sulfonamidas, inhiben su síntesis en bacterias, ejerciendo así sus efectos antimicrobianos. Su número CAS, 4033-27-6, se utiliza para la identificación en bases de datos químicas y contextos regulatorios. En general, ácido dihidrofólico es vital para mantener funciones celulares adecuadas y la salud en general.

Fórmula: C₁₉H₂₁N₇O₆

InChI: InChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/t12-/m0/s1

Clave InChI: InChIKey=OZRNSSUDZOLUSN-LBPRGKRZSA-N

SMILES: O=C1C2=C(NCC(CNC3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)NC(N)=N1

Sinónimos:

• 7,8-Dihydro-<span class="text-smallcaps">L</span>-folic acid
• 7,8-Dihydrofolic acid
• <span class="text-smallcaps">L</span>-Glutamic acid, N-[4-[[(2-amino-1,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-
• <span class="text-smallcaps">L</span>-Glutamic acid, N-[4-[[(2-amino-3,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-
• Dihydrofolate
• Glutamic acid, N-[p-[[(2-amino-7,8-dihydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-, <span class="text-smallcaps">L</span>-
• L-Glutamic acid, N-(4-(((2-amino-1,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)- (9CI)
• N-(4-{[(2-amino-4-oxo-1,4,7,8-tetrahydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
• N-(4-{[(2-amino-4-oxo-1,4,7,8-tetrahydropteridin-6-yl)methyl]amino}benzoyl)glutamic acid
• N-[4-[[(2-Amino-3,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-<span class="text-smallcaps">L</span>-glutamic acid
• Nsc 165989
• L-Glutamic acid, N-[4-[[(2-amino-1,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-
• L-Glutamic acid, N-[4-[[(2-amino-3,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-
• Dihydrofolic acid
• Glutamic acid, N-[p-[[(2-amino-7,8-dihydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-, L-
• N-[4-[[(2-Amino-3,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
• 7,8-Dihydropteroyl-L-glutaMic acid
• (S)-2-(4-(((2-aMino-4-oxo-1,4,7,8-tetrahydropteridin-6-yl)Methyl)aMino)benzaMido)pentanedioic acid
• Folic acid impurity 2/Folinic Acid EP Impurity G/Dihydrofolic acid/7,8-Dihydrofolic Acid
• Folinic Acid Impurity G (7,8-Dihydrofolic Acid)
• 7,8-Dihydropteroyl-L-glutamic acid, Dihydropteroyl-L-glutamic acid, FAH2
• Levofolinate EP Impurity G
• Folinic Acid EP Impurity G (7,8-Dihydrofolic Acid)
• 2-[4-[(2-amino-4-oxo-7,8-dihydro-1H-pteridin-6-yl)methylamino]benzoyl]aminopentanedioic acid
• N-[4-[[[(2-Amino-1,4,5,6-tetrahydro-4-oxopteridin)-6-yl]methyl]amino]benzoyl]-L-glutamic acid
• Impurity G of Calcium Levofolinate
• Folic Acid 7,8-Dihydro Impurity
• FAH2
• 7,8-DIHYDROPTEROYL-L-GLUTAMIC ACID
• DIHYDROPTEROYL-L-GLUTAMIC ACID
• Folinic Acid EP Impurity G

Dihydrofolic acid

CAS: 4033-27-6

Fórmula: C₁₉H₂₁N₇O₆

Pureza: 90%

Forma y color: Solid

Peso molecular: 443.4133

Ref: IN-DA003PJ0

(S)-2-(4-(((2-Amino-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)methyl)amino)benzamido)pentanedioic acid

CAS: 4033-27-6

(S)-2-(4-(((2-Amino-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)methyl)amino)benzamido)pentanedioic acid

Pureza: 90%

Peso molecular: 443.42g/mol

Ref: 54-OR1074661

Dihydrofolic acid

CAS: 4033-27-6

Fórmula: C₁₉H₂₁N₇O₆

Pureza: ≥ 90.0%

Forma y color: Off-white to beige or grey solid

Peso molecular: 443.41

Ref: 7W-GV4745

Dihydrofolic acid

CAS: 4033-27-6

Dihydrofolic acid (7,8-Dihydrofolic acid) is a folic acid derivative that produces tetrahydrofolic acid in the presence of dihydrofolic acid reductase.

Fórmula: C₁₉H₂₁N₇O₆

Pureza: 98%

Forma y color: Solid

Peso molecular: 443.41

Ref: TM-T15128

Dihydro Folic Acid

CAS: 4033-27-6

Stability Hygroscoipic, Light and Air Sensitive
Applications Dihydrofolic Acid is an intermediate in mammalian conversion of dietary folic acid to tetrahydrofolate by dihydrofolate reductase (DHFR). Folic acid (FA) and Dihydrofolic acid (FAH2) are substrates of dihydrofolate reductase(s) which reduce them to tetrahydrofolate (THF).
References Andres, J., et al.: Bioorg. Chem., 24, 10 (1996), Benkovic, S., et al.: Science, 301, 1196 (2003), ,,,,Williams, D; J Mol Biol 2003, 329, 389,,,Krahn, J., et al.: Biochemistry, 46, 14878 (2007),

Fórmula: C₁₉H₂₁N₇O₆

Forma y color: Light Beige To Grey

Peso molecular: 443.41

Ref: TR-D449700

Levofolinate EP Impurity G

CAS: 4033-27-6

Fórmula: C₁₉H₂₁N₇O₆

Peso molecular: 443.4

Ref: ST-EA-CP-L57007

Dihydrofolic acid

CAS: 4033-27-6

Dihydrofolic acid is an organic compound that is a derivative of folic acid. It is the reduced form of folic acid and can be used to treat certain autoimmune diseases, such as bowel disease. Dihydrofolic acid has been shown to have antimicrobial effects against infectious diseases, including tuberculosis. This compound can also be used to treat metal-chelate resistant bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA). Dihydrofolic acid has been shown to have neuroprotective properties in animals models and may be a potential drug target for the treatment of Alzheimer's disease.

Fórmula: C₁₉H₂₁N₇O₆

Pureza: (%) Min. 90%

Forma y color: Powder

Peso molecular: 443.41 g/mol

Ref: 3D-FD170209

Dihydro Folic Acid-D4 (Technical Grade)

Producto controlado

CAS: 4033-27-6

Fórmula: C₁₉D₄H₁₇N₇O₆

Forma y color: Neat

Peso molecular: 447.438

Ref: TR-D449702

7,8-Dihydrofolic Acid ((4-(((2-amino-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)methyl)amino)benzoyl)-L-glutamic acid)

CAS: 4033-27-6

Compounds containing a pyrimidine ring, whether or not hydrogenated, or piperazine ring in the structure, nesoi

Fórmula: C₁₉H₂₁N₇O₆

Forma y color: Brown Solid

Peso molecular: 443.15533

Ref: 45-1A06330