CAS 486-35-1

Dafnetina

Descripción:

Dafnetina, con el número CAS 486-35-1, es un derivado de cumarina que se encuentra de forma natural, extraído principalmente de la corteza del género Daphne, en particular de Daphne mezereum. Se caracteriza por su apariencia cristalina blanca y tiene una fórmula molecular de C10H8O4. Dafnetina exhibe una variedad de actividades biológicas, incluyendo propiedades antiinflamatorias, antioxidantes y antimicrobianas, lo que lo hace de interés en la investigación farmacológica. El compuesto es soluble en disolventes orgánicos como el etanol y el dimetilsulfóxido, pero tiene una solubilidad limitada en agua. La estructura de Dafnetina presenta un grupo hidroxilo y un grupo metoxi, lo que contribuye a su reactividad y posibles interacciones con varios objetivos biológicos. Además, se ha estudiado por sus posibles aplicaciones terapéuticas, incluyendo su papel en la modulación de vías de señalización relacionadas con la inflamación y el cáncer. Al igual que muchos compuestos naturales, se necesita más investigación para elucidar completamente sus mecanismos de acción y posibles usos clínicos.

Fórmula: C₉H₆O₄

InChI: InChI=1/C9H6O4/c10-6-3-1-5-2-4-7(11)13-9(5)8(6)12/h1-4,10,12H

Clave InChI: InChIKey=ATEFPOUAMCWAQS-UHFFFAOYSA-N

SMILES: OC1=C2C(=CC=C1O)C=CC(=O)O2

Sinónimos:

• 2H-1-Benzopyran-2-one, 7,8-dihydroxy-
• 2H-1-benzopyran-2-one, 4,8-dihydroxy-
• 4,8-Dihydroxy-2H-chromen-2-one
• 7,8-Dihydroxy-2H-1-benzopyran-2-one
• 7,8-Dihydroxycoumarin
• 7,8-dihydroxy-2H-benzopyran-2-one
• 7,8-dihydroxy-2H-chromen-2-one
• Coumarin, 7,8-dihydroxy-
• Daphnetol
• NSC 633563
• Ruixiangsu
• Daphnetin
• Daphenetin
• Daphnetin，7,8-Dihydroxycoumarin
• DAPHNETIN(P)
• AKOS 213-37
• 7,8-dihydroxy-coumari
• 7,8-DIHYDROXY-CHROMEN-2-ONE
• 7,8-dihydroxy-2h-1-benzopyran-2-on
• 7,8-DIHYDROXYCOUMARIN (DAPHNETIN)

Daphnetin

CAS: 486-35-1

Daphnetin analytical standard provided with chromatographic purity, to be used as reference material for qualitative determination.

Fórmula: C₉H₆O₄

Pureza: (HPLC) ≥95%

Forma y color: Powder

Peso molecular: 178.15

Ref: 11-0508

Daphnetin

CAS: 486-35-1

Daphnetin

Fórmula: C₉H₆O₄

Pureza: ≥95%

Peso molecular: 178.14

Ref: 54-BUP13671

2H-1-Benzopyran-2-one, 7,8-dihydroxy-

CAS: 486-35-1

Fórmula: C₉H₆O₄

Pureza: 95%

Forma y color: Solid

Peso molecular: 178.1415

Ref: IN-DA00IKJP

7,8-Dihydroxycoumarin

CAS: 486-35-1

7,8-Dihydroxycoumarin

Fórmula: C₉H₆O₄

Pureza: 98%

Forma y color: Solid

Peso molecular: 178.14154

Ref: 54-OR345097

7,8-Dihydroxycoumarin (Daphnetin)

CAS: 486-35-1

Fórmula: C₉H₆O₄

Pureza: (HPLC) ≥ 90.0%

Forma y color: Off-white to light yellow or pink powder

Peso molecular: 178.14

Ref: 7W-GE1263

Daphnetin

CAS: 486-35-1

Fórmula: C₉H₆O₄

Pureza: 95%~99%

Peso molecular: 178.143

Ref: BP-BP0449

7,8-Dihydroxycoumarin (Daphnetin)

CAS: 486-35-1

Fórmula: C₉H₆O₄

Peso molecular: 178.14

Ref: 4Z-C-1637

Daphnetin

CAS: 486-35-1

Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM),

Fórmula: C₉H₆O₄

Pureza: 97.47% - 99.95%

Forma y color: Solid

Peso molecular: 178.14

Ref: TM-T2851

Daphnetin

CAS: 486-35-1

7,8-Dihydroxy-2H-chromen-2-one

Fórmula: C₉H₆O₄

Pureza: 95%

Peso molecular: 178.14

Ref: IN-DG123444

Daphnetin

CAS: 486-35-1

Lactone

Fórmula: C₉H₆O₄

Pureza: ≥ 95.0 % (HPLC)

Forma y color: Powder

Peso molecular: 178.14

Ref: 5G-89621

7,8-Dihydroxycoumarin

CAS: 486-35-1

7,8-Dihydroxycoumarin is a naturally occurring coumarin, which is derived from plants and certain fungi. It possesses a distinct chemical structure characterized by a benzopyrone core with hydroxyl groups at the 7th and 8th positions, contributing to its distinct biochemical properties. The mode of action of 7,8-Dihydroxycoumarin is largely attributed to its ability to act as a potent antioxidant, scavenging free radicals and chelating metal ions, thus mitigating oxidative stress at the cellular level.

Fórmula: C₉H₆O₄

Pureza: Min. 95%

Forma y color: Powder

Peso molecular: 178.14 g/mol

Ref: 3D-FD67369

7,8-Dihydroxycoumarin, tech grade - 40%

CAS: 486-35-1

7,8-Dihydroxycoumarin (7,8-DHC) is a natural compound that has been shown to inhibit the expression of the P-glycoprotein (Pgp) gene and protein. 7,8-DHC binds to the response element in the Pgp gene promoter and inhibits transcriptional activity. This inhibition of transcription prevents the production of new Pgp proteins, which leads to an increase in drug resistance. 7,8-DHC also has been shown to bind to bcl-2 protein in vitro and prevent its release from mitochondria. This prevents apoptosis by inhibiting mitochondrial membrane permeability. Coumarin derivatives have been shown as potential therapeutic agents for bowel diseases such as ulcerative colitis and Crohn's disease. Daphnetin, a coumarin derivative found in dandelion roots, has shown promise as a treatment for colitis in mice models.

Fórmula: C₉H₆O₄

Pureza: (%) Min. 40%

Forma y color: Powder

Peso molecular: 178.14 g/mol

Ref: 3D-FD146393

DAPHNETIN

CAS: 486-35-1

Fórmula: C₉H₆O₄

Pureza: 97%

Peso molecular: 178.143

Ref: 10-F468316

Daphnetin

CAS: 486-35-1

Fórmula: C₉H₆O₄

Pureza: >90.0%(HPLC)

Forma y color: White to Light yellow to Light red powder to crystal

Peso molecular: 178.14

Ref: 3B-D4001