CAS 50-44-2

6-Mercaptopurina

Descripción:

6-Mercaptopurina es un análogo de purina y un antimetabolito utilizado principalmente en el tratamiento de ciertos tipos de leucemia, particularmente leucemia linfoblástica aguda (LLA) y leucemia mieloide crónica (LMC). Su fórmula química es C5H4N4S, y presenta un grupo tiol (-SH) que contribuye a su reactividad y actividad biológica. El compuesto actúa inhibiendo la síntesis de nucleótidos, interfiriendo así con la síntesis de ADN y ARN, lo cual es crucial para las células cancerosas que se dividen rápidamente. 6-Mercaptopurina se administra típicamente por vía oral y es conocido por sus posibles efectos secundarios, incluyendo mielosupresión, hepatotoxicidad y trastornos gastrointestinales. Se metaboliza en el hígado, y su eficacia puede verse influenciada por variaciones genéticas en las enzimas metabólicas, particularmente la tiopurina S-metiltransferasa (TPMT). Debido a su mecanismo de acción y perfil de efectos secundarios, a menudo son necesarios un monitoreo cuidadoso y ajustes de dosis durante el tratamiento. En general, 6-Mercaptopurina sigue siendo un agente terapéutico importante en oncología, particularmente en malignidades hematológicas pediátricas y adultas.

Fórmula: C₅H₄N₄S

InChI: InChI=1S/C5H4N4S/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10)

Clave InChI: InChIKey=GLVAUDGFNGKCSF-UHFFFAOYSA-N

SMILES: S=C1C2=C(NC=N1)N=CN2

Sinónimos:

• 1,7-Dihydro-6H-purine-6-thione
• 1,9-Dihydro-6H-purine-6-thione
• 1,9-Dihydro-purine-6-thione
• 1H-Purine, 6-mercapto-
• 3,5-dihydro-6H-purine-6-thione
• 3,7-Dihydropurine-6-thione
• 3H-Purine-6-thiol
• 6,9-dihydro-1H-purine
• 6-Mercaptopurin
• 6-Mercaptopurine
• 6-Mp
• 6-Thiohypoxanthine
• 6-Thiopurine
• 6-Thioxopurine
• 6H-Purine-6-thione, 1,7-dihydro-
• 6H-Purine-6-thione, 1,9-dihydro-
• 6H-purine-6-thione
• 6MP
• 7-Mercapto-1,3,4,6-tetrazaindene
• 9H-Purine-6(1H)-thione
• Hypoxanthine, thio-
• Ismipur
• Leukerin
• Leupurin
• Mercaleukim
• Mercaleukin
• Mercaptopurin
• Mercaptopurina
• Mercapurin
• Mern
• Nsc 55477
• Nsc 68293
• Nsc 755
• Purimethol
• Purine-6(1H)-thione
• Purine-6-Thiol
• Purine-6-thione
• Purinethiol
• Purinethol
• Purixan
• Thiohypoxanthine

6-Mercaptopurine

CAS: 50-44-2

6-Mercaptopurine (6-MP) is an antimetabolite antineoplastic agent with immunosuppressant properties.

Fórmula: C₅H₄N₄S

Pureza: 99.53% - 99.63%

Forma y color: Yellow Crystalline Powder Solid

Peso molecular: 152.18

Ref: TM-T0010

6-Mercaptopurine

CAS: 50-44-2

6-Mercaptopurine

Fórmula: C₅H₄N₄S

Pureza: 99.5%

Peso molecular: 152.18

Ref: 54-BUP11953

6-Mercaptopurine

CAS: 50-44-2

6-Mercaptopurine

Fórmula: C₅H₄N₄S

Pureza: 98%

Forma y color: Pale yellow Solid

Peso molecular: 152.17705

Ref: 54-BI9878

6-Mercaptopurine-13C-15N2 (Azathioprine EP Impurity B-13C-15N2)

CAS: 207729-57-5, 50-44-2, 6112-76-1

Fórmula: C₄₁₃CH₄N₂₁₅N₂S

Peso molecular: 155.15

Ref: 4Z-M-834

6-Mercaptopurine

CAS: 50-44-2

Fórmula: C₅H₄N₄S

Peso molecular: 152.18

Ref: 7W-GP0789

6-Mercaptopurine (Azathioprine EP Impurity B)

CAS: 50-44-2

Fórmula: C₅H₄N₄S

Forma y color: Yellow Solid

Peso molecular: 152.18

Ref: 4Z-M-832

6-Mercaptopurine

CAS: 50-44-2

Fórmula: C₅H₄N₄S

Pureza: 95%

Forma y color: Solid

Peso molecular: 152.1771

Ref: IN-DA0038PH

6-Mercaptopurine (Standard)

CAS: 50-44-2

6-Mercaptopurine (Standard) is a reference standard for research and analysis in studies involving 6-Mercaptopurine. 6-Mercaptopurine (6-MP) is an antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.

Fórmula: C₅H₄N₄S

Peso molecular: 152.18

Ref: TM-TMSM-3693

6-Mercaptopurine

CAS: 50-44-2

3,7-dihydro-6H-purine-6-thione

Fórmula: C₅H₄N₄S

Pureza: 98%

Peso molecular: 152.18

Ref: IN-DG33839

6-Mercaptopurine

CAS: 50-44-2

6-Mercaptopurine is an antigen binding molecule that is biocompatible with the human body. It binds to 6-mercaptopurine and inhibits the oxidation of proteins. The inhibition of protein oxidation has been shown to decrease disease activity in patients with inflammatory bowel disease. 6-Mercaptopurine also inhibits the production of inhibitor molecules, which are responsible for the development of cardiac effects such as arrhythmias and cardiomyopathy. 6-Mercaptopurine has inhibitory properties against polymerase chain reactions, which may be due to its ability to bind with protein thiols at high rates.

Fórmula: C₅H₄N₄S

Pureza: Min. 98 Area-%

Forma y color: Powder

Peso molecular: 152.18 g/mol

Ref: 3D-FM61589

6-Mercaptopurine

CAS: 50-44-2

Fórmula: C₅H₄N₄S

Forma y color: Solid

Peso molecular: 152.18

Ref: BE-RMCM109002

6-Mercaptopurine

CAS: 50-44-2

Fórmula: C₅H₄N₄S

Forma y color: Solid

Peso molecular: 152.18

Ref: BE-MU-8296

6-Mercaptopurine

CAS: 50-44-2

Fórmula: C₅H₄N₄S

Pureza: 95%

Forma y color: Solid

Peso molecular: 152.18

Ref: 10-F050540

Mercaptopurine

CAS: 50-44-2

Fórmula: C₅H₄N₄S

Peso molecular: 152.17

Ref: ST-EA-CP-M81000