CAS 50-91-9
:Floxuridina
Descripción:
Floxuridina, con el número CAS 50-91-9, es un antimetabolito sintético y un análogo fluorurado de la uridina. Se utiliza principalmente en el tratamiento de ciertos tipos de cáncer, particularmente el cáncer colorrectal y las metástasis hepáticas. El compuesto funciona inhibiendo la síntesis de ADN, interfiriendo así con la proliferación de células cancerosas. Floxuridina se administra típicamente por inyección intravenosa o infusión intra-arterial, permitiendo una entrega dirigida a los sitios tumorales. Su estructura química incluye un átomo de flúor, que mejora su actividad antitumoral en comparación con sus contrapartes no fluoradas. La sustancia es conocida por sus posibles efectos secundarios, que pueden incluir mielosupresión, trastornos gastrointestinales y mucositis. Debido a sus potentes efectos y aplicación específica en oncología, Floxuridina se clasifica como un agente citotóxico y se maneja con cuidado en entornos clínicos. Al igual que con muchos agentes quimioterapéuticos, es esencial monitorear las reacciones adversas durante el tratamiento.
Fórmula:C9H11FN2O5
InChI:InChI=1/C9H11FN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6-,7?/m1/s1
Clave InChI:InChIKey=ODKNJVUHOIMIIZ-RRKCRQDMSA-N
SMILES:O=C1N([C@@H]2O[C@H](CO)[C@@H](O)C2)C=C(F)C(=O)N1
Sinónimos:- (+)-5-Fluorodeoxyuridine
- 1-(2-Deoxy-β-<span class="text-smallcaps">D</span>-ribofuranosyl)-5-fluorouracil
- 1-(2-Deoxy-β-D-ribofuranosyl)-5-fluorouracil
- 1-(2-deoxy-D-threo-pentofuranosyl)-5-fluoropyrimidine-2,4(1H,3H)-dione
- 1-(2-deoxypentofuranosyl)-5-fluoropyrimidine-2,4(1H,3H)-dione
- 2-Deoxy-5-fluorouridine
- 5-Fluoro-2'-deoxy-β-uridine
- 5-Fluoro-2?Deoxy Uridine
- 5-Fluorouracil 2'-deoxyriboside
- 5-Fluorouracil deoxyriboside
- 5-Fudr
- Deoxyfluorouridine
- FdUrd
- Floxiridina
- Floxuridin
- Floxuridine
- Fudr
- Nsc 26740
- Nsc 27640
- Uridine, 2'-deoxy-5-fluoro-
- 5-Fluoro-2′-deoxyuridine
- 5-Fluoro-2'-deoxyuridine
- 5-Fluoro-2-deoxyuridine
- (+)-5-Fluoro-2?deoxyuridine
- 5-FDU
- 5-FLOXURIDINE
- 2’-deoxy-5-fluoro-uridin
- 1-beta-d-2’-deoxyribofuranosyl-5-flurouracil
- 1beta-D-2'-Deoxyribofuranosyl-5-fluorouracil
- 5-FLUORO-2'-DEOXY-BETA-URIDINE
- 5-FLUORO-1-((2R,4S,5R)-4-HYDROXY-5-HYDROXYMETHYL-TETRAHYDRO-FURAN-2-YL)-1H-PYRIMIDINE-2,4-DIONE
- fluorodeoxyuridine
- 1-(2-DEOXY-BETA-D-RIBOFURANOSYL)-5-FLUOROURACIL
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2'-Deoxy-5-fluorouridine
CAS:Fórmula:C9H11FN2O5Pureza:>98.0%(HPLC)(T)Forma y color:White to Almost white powder to crystalPeso molecular:246.195-Fluoro-2'-deoxyuridine, 98+%
CAS:5-Fluoro-2'-deoxyuridine acts as an antiviral and antineoplastic agent. It is also employed for renal function diagnosis. Further, it is used as an experimental anticancer agent, which shows activity against a variety of malignant neoplasms. It is also used as an inhibitor of thymidylate synthetaseFórmula:C9H11FN2O5Pureza:98+%Forma y color:Powder, White to pale creamPeso molecular:246.19Floxuridine
CAS:Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoiFórmula:C9H11FN2O5Forma y color:White Off-White PowderPeso molecular:246.19Floxuridine
CAS:Floxuridine (FUDR) is an antimetabolite, floxuridine inhibits thymidylate synthase, resulting in disruption of DNA synthesis and cytotoxicity.Fórmula:C9H11FN2O5Pureza:98.92% - 99.96%Forma y color:SolidPeso molecular:246.19245-Fluoro-2'-deoxyuridine
CAS:5-Fluoro-2'-deoxyuridineFórmula:C9H11FN2O5Pureza:99%Forma y color:White SolidPeso molecular:246.19244Floxuridine
CAS:Fórmula:C9H11FN2O5Pureza:(HPLC) ≥ 98.0%Forma y color:White to off-white powderPeso molecular:246.20Floxuridine
CAS:Producto controladoApplications Floxuridine is an antiviral; antineoplastic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Harris, M., et al.: Biophys. J., 4, 203 (1964),Fórmula:C9H11FN2O5Forma y color:NeatPeso molecular:246.19Floxuridine-13C,15N2
CAS:Producto controladoApplications Labelled Floxuridine. Antiviral; antineoplastic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Harris, M., et al.: Biophys. J., 4, 203 (1964),Fórmula:C813CH11F15N2O5Forma y color:NeatPeso molecular:249.17Floxuridine
CAS:5-Fluoro-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dioneFórmula:C9H11FN2O5Pureza:98%Peso molecular:246.192'-Deoxy-5-fluorouridine
CAS:2'-Deoxy-5-fluorouridine is a nucleoside analog that inhibits the enzyme ribonucleotide reductase, which is involved in the synthesis of DNA. It has been shown to inhibit the growth of cancer cells and induce apoptosis in vivo. 2'-Deoxy-5-fluorouridine has also been shown to inhibit tumor growth in animal models by inhibiting the production of reactive oxygen species and upregulating tumor suppressor genes, such as p53. This drug also has inhibitory effects on enzymes that are involved in cell proliferation, such as protein kinase C and tyrosine kinases. 2'-Deoxy-5-fluorouridine is metabolized by water vapor, so it must be administered with a humidifier or nebulizer. 2'-Deoxy-5-fluorouridine may cause side effects such as nausea, vomiting, and diarrhea.Fórmula:C9H11FN2O5Pureza:Min. 98 Area-%Forma y color:White Off-White PowderPeso molecular:246.2 g/mol5-Fluoro-2-Deoxyuridine extrapure, 98%
CAS:Fórmula:C9H11FN2O5Pureza:min. 98%Forma y color:White to off white, Crystalline powderPeso molecular:246.20
